{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T10:50:46Z","timestamp":1780656646791,"version":"3.54.1"},"reference-count":24,"publisher":"Korean Society of Pediatric Endocrinology","issue":"1","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004776","name":"Faculty of Medicine, Chulalongkorn University","doi-asserted-by":"publisher","award":["RA61\/030"],"award-info":[{"award-number":["RA61\/030"]}],"id":[{"id":"10.13039\/501100004776","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["e-apem.org"],"crossmark-restriction":true},"short-container-title":["Ann Pediatr Endocrinol Metab"],"published-print":{"date-parts":[[2023,3,31]]},"abstract":"<jats:p>Purpose: Diabetic neuropathy (DN) is a serious complication in diabetes mellitus. We aimed to determine the prevalence of DN in pediatric-onset diabetes in a tertiary care center and to assess the sensitivity and specificity of monofilament testing and noninvasive screening to diagnose DN compared with the gold standard nerve conduction study (NCS).Methods: Sixty-five Thai children and adolescents (39 females) diagnosed with diabetes before 15 years of age were included. All subjects were screened for DN by foot and neurological examinations, light touch sensation by 10 g Semmes-Weinstein monofilaments, and the Michigan Neuropathy Screening Instrument (MNSI). NCSs were used as the gold standard for diagnosis of DN.Results: Fifty-eight patients had type 1 diabetes ( T1D), 5 patients had type 2 diabetes, and 2 patients had other types of diabetes. The mean age was 17.7\u00b14.6 years (8\u201333 years). The prevalence of DN in this cohort was 12.3% by NCS. All subjects were asymptomatic. Mean diabetes duration did not differ between the groups (with DN 8.0\u00b13.0 years vs. no DN 8.2\u00b15.0 years). Notably, one patient with T1D developed DN within 3 years after diagnosis. Poor glycemic control was a significant risk factor for DN. Glycosylated hemoglobin was higher in the DN group (10.6%\u00b12.3% vs. 8.5%\u00b11.6%, P=0.008). The occurrence of diabetic nephropathy was associated with DN (prevalence rate ratio, 4.97; 95% confidence interval, 1.5\u201316.46). Foot and neurological examinations, monofilaments, and the MNSI failed to detect DN in all subjects with abnormal NCS.Conclusion: The prevalence of DN in pediatric-onset diabetes is not uncommon but mainly is subclinical. Poor glycemic control is the main risk factor. Noninvasive screening tests for DN exhibited poor diagnostic sensitivity in the pediatric population.<\/jats:p>","DOI":"10.6065\/apem.2244092.046","type":"journal-article","created":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T00:32:12Z","timestamp":1680222732000},"page":"20-25","update-policy":"https:\/\/doi.org\/10.6065\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The prevalence of diabetic peripheral neuropathy in youth with diabetes mellitus"],"prefix":"10.6065","volume":"28","author":[{"given":"Piengjai","family":"Sophausvaporn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8534-0690","authenticated-orcid":true,"given":"Jariya","family":"Boonhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7310-3997","authenticated-orcid":true,"given":"Taninee","family":"Sahakitrungruang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4096","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.13153"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.2337\/dc17-0179"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.12382"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-5448.2009.00636.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-5448.2002.30207.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.2337\/dc05-2470"},{"key":"ref7","first-page":"3903","volume-title":"Peripheral neuropathy in adolescents and young adults with type 1 and type 2 diabetes from the SEARCH for diabetes in youth follow-up cohort: a pilot study","author":"Jaiswal","year":"2013"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.2337\/dc21-s013"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.12742"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-3645"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.17.11.1281"},{"key":"ref12","first-page":"307","volume-title":"Validity and reliability of the Michigan Neuropathy Screening Instrument (MNSI) on the diabetic type II patients (Thai version)","author":"Damri","year":"2015"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-5491.2012.03644.x"},{"key":"ref14","first-page":"1679","volume-title":"Comprehensive foot examination and risk assessment: a report of the task force of the foot care interest group of the American Diabetes Association, with endorsement by the American Association of Clinical Endocrinologists","author":"Boulton","year":"2008"},{"key":"ref15","first-page":"71","volume-title":"The comparison of nerve conduction studies in normal subjects by using MEDELEC and NIHON KOHDEN","author":"Permsirivanich","year":"2003"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.2337\/dc10-1303"},{"key":"ref17","first-page":"369","volume-title":"","author":"Kang","year":"2007"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1177\/088307388600100103"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1997.tb09023.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-014-0528-7"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410380607"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1056\/nejm199309303291401"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-543x.2004.00041.x"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.2337\/ds18-0036"}],"container-title":["Annals of Pediatric Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/e-apem.org\/upload\/pdf\/apem-2244092-046.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/e-apem.org\/journal\/view.php?doi=10.6065\/apem.2244092.046","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/e-apem.org\/upload\/pdf\/apem-2244092-046.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,4]],"date-time":"2023-04-04T01:56:54Z","timestamp":1680573414000},"score":1,"resource":{"primary":{"URL":"http:\/\/e-apem.org\/journal\/view.php?doi=10.6065\/apem.2244092.046"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,31]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,3]]}},"URL":"https:\/\/doi.org\/10.6065\/apem.2244092.046","relation":{},"ISSN":["2287-1012","2287-1292"],"issn-type":[{"value":"2287-1012","type":"print"},{"value":"2287-1292","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,31]]},"assertion":[{"value":"2022-04-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-01","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-31","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}