{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T21:57:48Z","timestamp":1791755868200,"version":"4.3.4"},"reference-count":29,"publisher":"Korean Society of Pediatric Endocrinology","issue":"3","license":[{"start":{"date-parts":[[2024,1,29]],"date-time":"2024-01-29T00:00:00Z","timestamp":1706486400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["e-apem.org"],"crossmark-restriction":true},"short-container-title":["Ann Pediatr Endocrinol Metab"],"published-print":{"date-parts":[[2024,6,30]]},"abstract":"<jats:p>Purpose: Three-month gonadotropin-releasing hormone agonists (GnRHas) are expected to achieve better compliance in patients with central precocious puberty (CPP) compared to the monthly formulation. However, 1-month depot remains the dominant choice for conventional treatment worldwide. Our study aimed to investigate the long-term efficacy of a 3-month GnRHa for CPP treatment.Methods: In this retrospective study, 69 Korean girls with CPP were prescribed either triptorelin pamoate (TP) 3-month depot (n=29) or triptorelin acetate (TA) 1-month depot (n=40) and were followed for 1 year after the end of treatment. Auxological, radiological, and biochemical data were collected every 6 months.Results: Baseline characteristics were similar between the 2 groups. In the TP 3-month depot group, 27 of 29 patients (93.1%) exhibited suppressed luteinizing hormone level (below 2.5 IU\/L) after 6 months of treatment, and this suppression level was reserved until the final injection. The degree of bone age advancement in the TP 3-month depot group decreased from 1.8\u00b10.4 years at the start of treatment to 0.6\u00b10.5 years at 1-year posttreatment. The gain in predicted adult height (PAH) 1 year after the end of treatment was similar between the TP 3-month and TA 1-month depot groups (5.2\u00b13.1 and 5.3\u00b12.4 cm, respectively; &lt;i&gt;p&lt;\/i&gt;=0.875).Conclusion: A 3-month depot of triptorelin effectively inhibited gonadal and sex hormones, suppressed bone maturation, and increased PAH. For patient convenience, we suggest a 3-month GnRHa regimen as a promising CPP treatment option.<\/jats:p>","DOI":"10.6065\/apem.2346132.066","type":"journal-article","created":{"date-parts":[[2024,1,28]],"date-time":"2024-01-28T10:46:06Z","timestamp":1706438766000},"page":"161-166","update-policy":"https:\/\/doi.org\/10.6065\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Long-term efficacy of a triptorelin 3-month depot in girls with central precocious puberty"],"prefix":"10.6065","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4288-3820","authenticated-orcid":true,"given":"Kyu Hyun","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6313-2551","authenticated-orcid":true,"given":"Si-Hwa","family":"Gwag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9063-2006","authenticated-orcid":true,"given":"Yu Jin","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7447-6250","authenticated-orcid":true,"given":"Lindsey Yoojin","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6544-3599","authenticated-orcid":true,"given":"Eungu","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1512-2062","authenticated-orcid":true,"given":"Hyo-Kyoung","family":"Nam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1250-6469","authenticated-orcid":true,"given":"Young-Jun","family":"Rhie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4319-9019","authenticated-orcid":true,"given":"Kee-Hyoung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4096","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-1783"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.6065\/apem.2014.19.1.27"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2018.12.022"},{"key":"ref4","first-page":"1546","volume-title":"Short-term treatment of idiopathic precocious puberty with a long-acting analog of luteinizing-hormonereleasing hormone - a preliminary-report","author":"Comite","year":"1981"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.me.34.020183.002423"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2006.04.012"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-0321"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3346\/jkms.2021.36.e219"},{"key":"ref9","first-page":"963","volume-title":"Treatment of central precocious puberty with triptorelin 11.25 mg depot formulation","author":"Martinez-Aguayo","year":"2006"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1530\/eje.1.02056"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.6065\/apem.2040134.067"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/1043293"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1515\/jpem-2021-0142"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159\/000441497"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2020.1770723"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2019.1655726"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-3476(95)70255-5"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.6065\/apem.2012.17.3.153"},{"key":"ref19","volume-title":"","author":"Greulich","year":"1959"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-3476(52)80205-7"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1542\/peds.109.2.e30"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.4274\/jcrpe.3091"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1002\/oby.21010"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2011.05.036"},{"key":"ref25","first-page":"R79","volume-title":"Long-term outcomes of the treatment of central precocious puberty","author":"Guaraldi","year":"2016"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1210\/jc.79.2.415"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1136\/adc.75.4.292"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1410140"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1210\/jc.86.10.4711"}],"container-title":["Annals of Pediatric Endocrinology &amp; 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