{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T23:27:35Z","timestamp":1792193255043,"version":"4.4.0"},"reference-count":30,"publisher":"Korean Society of Pediatric Endocrinology","issue":"5","license":[{"start":{"date-parts":[[2024,10,31]],"date-time":"2024-10-31T00:00:00Z","timestamp":1730332800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["e-apem.org"],"crossmark-restriction":true},"short-container-title":["Ann Pediatr Endocrinol Metab"],"published-print":{"date-parts":[[2024,10,31]]},"abstract":"<jats:p>Purpose: Short stature is the main characteristic of Turner syndrome (TS) patients and growth hormone (GH) therapy has been essential for achieving the final adult height (Ht). In the present study, the response of TS patients with different types of karyotype abnormalities to GH therapy was analyzed.Methods: The clinical parameters of 194 TS patients registered in the LG Growth Study were retrospectively reviewed. Data for 4 groups of subjects were obtained as follows: monosomy X (n=56); X structural abnormality (n=26); X mosaicism without structural abnormality (n=41); X mosaicism with structural abnormality (n=71). Clinical characteristics and growth response parameters were compared over 3 years of GH treatment.Results: The baseline Ht standard deviation score (SDS) of all patients was -2.85\u00b10.86. The baseline Ht SDS, body mass index SDS, and chronological age (years)-bone age (years) were significantly different based on chromosomal abnormalities. The growth velocity (GV; cm\/yr) in the first year was the highest and significantly different among the groups. The GV in the second year also showed an increase in the X mosaicism without structural abnormality group compared with the monosomy X group. The change in Ht SDS (\u0394Ht SDS) over 3 years was not statistically different between karyotypes.Conclusion: The response to 3 years of GH therapy did not differ based on the karyotype of TS patients although the initial Ht SDS was the lowest in the monosomy X group.<\/jats:p>","DOI":"10.6065\/apem.2346246.123","type":"journal-article","created":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T09:02:35Z","timestamp":1730278955000},"page":"308-315","update-policy":"https:\/\/doi.org\/10.6065\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Response of children with Turner syndrome with different types of karyotype abnormalities to growth hormone treatment"],"prefix":"10.6065","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8956-4192","authenticated-orcid":true,"given":"Jung Eun","family":"Choi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7202-500X","authenticated-orcid":true,"given":"Mi Jung","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0020-2000","authenticated-orcid":true,"given":"Jeesuk","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6976-6878","authenticated-orcid":true,"given":"Hae Soon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4096","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.6065\/apem.2013.18.1.13"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1530\/ec-18-0115"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159\/000381712"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00054"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1530\/eje-15-1000e"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-2187"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-2874"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159\/000336806"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.k08e-144"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1515\/jpem-2019-0311"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021171"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ando.2017.10.011"},{"key":"ref13","first-page":"33","volume-title":"The changing face of Turner syndrome. The changing face of Turner syndrome","author":"Gravholt","year":"2023"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1186\/s13023-022-02423-5"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.6065\/apem.2018.23.1.43"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.3345\/kjp.2018.61.5.135"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1210\/endo-meetings.2010.part2.p4.p2-179"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10215076"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1530\/eje-17-0430"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111\/cen.13394"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.3345\/kjp.2010.53.2.158"},{"key":"ref22","first-page":"29","volume-title":"Effect of growth hormone treatment on children with idiopathic short stature (ISS), idiopathic growth hormone deficiency (IGHD), small for gestational age (SGA) and Turner syndrome (TS) in a tertiary care center","author":"Al Shaikh","year":"2020"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1210\/jc.84.12.4607"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2002-021171"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1507\/endocrj.ej16-0170"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1056\/nejmoa1005669"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2019.04.056"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1530\/eje-13-0069"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.6065\/apem.2142110.055"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.6065\/apem.2244028.014"}],"container-title":["Annals of Pediatric Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/e-apem.org\/upload\/pdf\/apem-2346246-123.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/e-apem.org\/journal\/view.php?doi=10.6065\/apem.2346246.123","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/e-apem.org\/upload\/pdf\/apem-2346246-123.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T09:03:30Z","timestamp":1730279010000},"score":1,"resource":{"primary":{"URL":"http:\/\/e-apem.org\/journal\/view.php?doi=10.6065\/apem.2346246.123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,31]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,10]]}},"URL":"https:\/\/doi.org\/10.6065\/apem.2346246.123","relation":{},"ISSN":["2287-1012","2287-1292"],"issn-type":[{"value":"2287-1012","type":"print"},{"value":"2287-1292","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,31]]},"assertion":[{"value":"2023-12-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-04-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-31","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-31","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}