{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T22:00:14Z","timestamp":1791756014294,"version":"4.3.4"},"reference-count":26,"publisher":"Korean Society of Pediatric Endocrinology","issue":"1","license":[{"start":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T00:00:00Z","timestamp":1740700800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["e-apem.org"],"crossmark-restriction":true},"short-container-title":["Ann Pediatr Endocrinol Metab"],"published-print":{"date-parts":[[2025,2,28]]},"abstract":"<jats:p>Purpose: This study aimed to examine the effects of gonadotropin-releasing hormone agonist (GnRHa) treatment on final height outcomes in girls with idiopathic central precocious puberty (CPP) from the start of treatment to their postmenarche visit.Methods: We conducted a retrospective analysis of 200 girls with idiopathic CPP who received GnRHa therapy, focusing on auxological and clinical outcomes at treatment initiation, treatment completion, and the last, postmenarche visit.Results: The mean chronological age (CA) at GnRHa treatment initiation was 8.24\u00b10.73 years. The mean duration of GnRHa treatment was 3.12\u00b10.81 years. The average age at menarche was 12.73\u00b10.56 years, occurring a mean of 17.15\u00b15.52 months after completing GnRHa therapy. The predicted adult height (PAH) standard deviation score (SDS) after menarche (0.48\u00b10.99) was significantly greater than before treatment (-1.33\u00b11.46) (P&lt;0.001). Factors including greater bone age advancement (P&lt;0.001), lower height SDS for CA at treatment initiation (P&lt;0.001), and higher midparental height SDS (P=0.001) were positively associated with an increase in PAH SDS at the last visit. However, near-final height and the increase in PAH SDS at the last visit were not significantly different between patients who received early treatment (&lt;8 years) and those who received later treatment (8\u20139 years).Conclusion: GnRHa treatment improved the final height outcomes in all girls with CPP, including those treated between 8 and 9 years of age.<\/jats:p>","DOI":"10.6065\/apem.2448038.019","type":"journal-article","created":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T23:06:48Z","timestamp":1740611208000},"page":"31-37","update-policy":"https:\/\/doi.org\/10.6065\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Long-term outcomes of gonadotropin-releasing hormone agonist treatment in girls with central precocious puberty"],"prefix":"10.6065","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0237-0415","authenticated-orcid":true,"given":"Jung","family":"Hwangbo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6544-3599","authenticated-orcid":true,"given":"Eungu","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1512-2062","authenticated-orcid":true,"given":"Hyo-Kyoung","family":"Nam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1250-6469","authenticated-orcid":true,"given":"Young-Jun","family":"Rhie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4319-9019","authenticated-orcid":true,"given":"Kee-Hyoung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4096","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056\/nejmcp0800459"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1530\/eje-15-0590"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1136\/adc.75.4.292"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-1216"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.12659\/msm.881794"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1210\/jc.86.10.4711"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-0321"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1515\/jpem.2000.13.s1.747"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1515\/jpem.2000.13.s1.765"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-1783"},{"key":"ref11","first-page":"1973","volume-title":"Final height after long-term treatment with triptorelin slow release for central precocious puberty: importance of statural growth after interruption of treatment. 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