{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T05:43:32Z","timestamp":1784958212261,"version":"3.55.0"},"reference-count":18,"publisher":"Korean Society of Pediatric Endocrinology","issue":"3","license":[{"start":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T00:00:00Z","timestamp":1751241600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007693","name":"King Chulalongkorn Memorial Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007693","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002873","name":"Chulalongkorn University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002873","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["e-apem.org"],"crossmark-restriction":true},"short-container-title":["Ann Pediatr Endocrinol Metab"],"published-print":{"date-parts":[[2025,6,30]]},"abstract":"<jats:p>Purpose: Acute leukemia is the most common form of malignancy in children; however, there is an absence of data regarding the long-term ovarian reserve of female survivors. The purpose of this investigation was to examine potential discrepancies in anti-Mullerian hormone (AMH) levels among female survivors of pediatric acute leukemia.Methods: A cross-sectional study was conducted on female survivors aged 2 to 18 years who completed gonadotoxic chemotherapy sessions at least 1 year prior to evaluation. Based on Tanner staging, the participants were divided into pre-pubertal and pubertal groups. Serum AMH, follicle stimulating hormone (FSH), luteinizing hormone (LH), and estradiol were assessed.Results: Three of 36 participants demonstrated low AMH levels in comparison to the adjusted age-reference range, whereas all participants had normal FSH and LH levels. However, the correlation between cumulative dose of cyclophosphamide and AMH level was not statistically significant.Conclusion: Measurement of AMH level may not be beneficial in individuals who have received a cumulative dose of cyclophosphamide less than 5,400 mg\/m&lt;sup&gt;2&lt;\/sup&gt;.<\/jats:p>","DOI":"10.6065\/apem.2448146.073","type":"journal-article","created":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T00:12:56Z","timestamp":1750983176000},"page":"135-139","update-policy":"https:\/\/doi.org\/10.6065\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Assessing the ovarian reserve in girls who survived childhood leukemia using anti-Mullerian hormone"],"prefix":"10.6065","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-1043-0925","authenticated-orcid":true,"given":"Lalita","family":"Jingrukwong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2017-7830","authenticated-orcid":true,"given":"Khomsak","family":"Srilanchakon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2432-8022","authenticated-orcid":true,"given":"Supanun","family":"Lauhasurayotin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7563-5287","authenticated-orcid":true,"given":"Kanhatai","family":"Chiengthong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4096","reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1677\/erc-10-0002"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097\/aog.0000000000002763"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.4274\/tjh.2015.0332"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2008.21.1839"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2000.1.285"},{"key":"ref6","first-page":"182","volume-title":"Ovarian response biomarkers: physiology and performance","author":"Iliodromiti","year":"2015"},{"key":"ref7","first-page":"198698","volume-title":"Anti-m\u00fcllerian hormone and its clinical use in pediatrics with special emphasis on disorders of sex development","author":"Lindhardt Johansen","year":"2013"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/s0303-7207(98)00186-5"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-1440"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-019-01622-7"},{"key":"ref11","first-page":"5144","volume-title":"Clinical utility of measurement of antimullerian hormone in reproductive endocrinology","author":"Ledger","year":"2010"},{"key":"ref12","first-page":"982","volume-title":"Assessment of ovarian reserve in adult childhood cancer survivors using anti-M\u00fcllerian hormone","author":"Lie Fong","year":"2009"},{"key":"ref13","first-page":"2368","volume-title":"Depletion of ovarian reserve in young women after treatment for cancer in childhood: detection by anti-M\u00fcllerian hormone, inhibin B and ovarian ultrasound","author":"Bath","year":"2003"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1297\/cpe.25.119"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2022.06.005"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.08.052"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2011-3180"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1530\/eje-21-0351"}],"container-title":["Annals of Pediatric Endocrinology &amp; 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