{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T05:47:18Z","timestamp":1782712038704,"version":"3.54.5"},"reference-count":46,"publisher":"Korean Society of Pediatric Endocrinology","issue":"3","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Gene Science Pharmaceuticals Co., Ltd."}],"content-domain":{"domain":["e-apem.org"],"crossmark-restriction":true},"short-container-title":["Ann Pediatr Endocrinol Metab"],"published-print":{"date-parts":[[2026,6,30]]},"abstract":"<jats:p>Purpose: Polyethylene glycol-recombinant human growth hormone (PEG-rhGH) is the first commercial long-acting rhGH preparation approved in China. This study was designed to assess the efficacy and safety of PEG-rhGH in treating growth hormone deficiency (GHD) during the transition period.Methods: A prospective, multicenter and single-arm study was performed. The entire study duration spanned 66 weeks, comprising a 2-week trial screening phase, a 12-week dose-adjustment period, and a 52-week PEG-rhGH treatment phase. A total of 10 interviews were conducted over the course of the study. The primary endpoint was change in body composition; secondary endpoints were changes in lumbar bone mineral density (BMD, L1\u20134) and lean body mass (LBM). Sex- and age-specific equations were developed to adjust body composition z-scores.Results: : A total of 31 subjects were included in this study. Throughout the 64-week therapy with PEG-rhGH, the insulin-like growth factor-1 (IGF-1) standard deviation score (SDS) demonstrated progressive elevation from baseline (-3.07 to -1.38; P&lt;0.001). Significant alterations in body composition parameters were observed throughout the study. Body weight increased 3.96 kg (P&lt;0.001), and the body weight SDS exhibited significant elevation from baseline (0.67) to 64 weeks (1.14; P=0.005). LBM significantly increased (4.54 kg; P&lt;0.001), but there was a statistically significant reduction in fat percentage (Fat%) from 37.40% to 33.94% (P=0.008) and Fat% SDS from 1.91 to 1.47 (P= 0.009). The lumbar BMD z-score improved from -1.54 at baseline to -1.12 postintervention, but did not reach statistical significance (P&gt;0.05). The triglyceride (TG) levels of the subjects decreased significantly at week 64 (P=0.018). There was no statistically significant difference in the changes of other lipid profile indicators. In this study, no adverse events attributable to direct drug-related causes were identified.Conclusion: Based on our study, PEG-rhGH can improve IGF-1 levels and alter body composition parameters by increasing LBM and decreasing body fat and TG levels in patients with GHD during the transition period, and it has a comparable safety profile and helps improve therapeutic adherence.<\/jats:p>","DOI":"10.6065\/apem.2550238.119","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T05:31:33Z","timestamp":1782711093000},"page":"178-188","update-policy":"https:\/\/doi.org\/10.6065\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Metabolic and bone effects of long-acting polyethylene glycol-recombinant human growth hormone in growth hormone deficiency during the transition period: a prospective study"],"prefix":"10.6065","volume":"31","author":[{"given":"Ke","family":"Huang","sequence":"first","affiliation":[{"name":"Children's Hospital Zhejiang University School of Medicine, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hu","family":"Lin","sequence":"additional","affiliation":[{"name":"Children's Hospital Zhejiang University School of Medicine, Hangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lifen","family":"Chen","sequence":"additional","affiliation":[{"name":"Ruijin Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiya","family":"Dong","sequence":"additional","affiliation":[{"name":"Ruijin Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhong","family":"Li","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guimei","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Yao","sequence":"additional","affiliation":[{"name":"Wuhan Children's Hospital (Wuhan Maternal and Child Health Hospital, Wuhan Women's and Children's Health Care Center), Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2330-4977","authenticated-orcid":true,"given":"Shouyue","family":"Sun","sequence":"additional","affiliation":[{"name":"Ruijin Hospital Shanghai Jiao Tong University School of Medicine, Shanghai, 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