{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T02:17:18Z","timestamp":1787883438940,"version":"build-2784847793"},"reference-count":20,"publisher":"Korean Society of Pediatric Endocrinology","issue":"4","license":[{"start":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T00:00:00Z","timestamp":1766793600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["e-apem.org"],"crossmark-restriction":true},"short-container-title":["Ann Pediatr Endocrinol Metab"],"published-print":{"date-parts":[[2026,8,31]]},"abstract":"<jats:p>Recent literature has highlighted an association between severe atopic dermatitis (AD) in infancy and biochemical disturbances consistent with secondary hyperaldosteronism. Transepidermal sodium loss driving volume depletion has been hypothesized to contribute to this process, but direct evidence of the underlying mechanisms remains sparse. We present a case series of 3 children, aged 3 to 7 months, who were admitted with severe exudative eczema associated with hyponatremia and hyperkalemia, despite evidence of effective renin-angiotensin-aldosterone system activation and renal mineralocorticoid action. In each case, these biochemical and hormonal disturbances resolved after optimizing dermatological and nutritional management of their atopic presentations, supporting the role of extrarenal mechanisms of electrolyte disturbance. Our case series highlights the importance of considering biochemical and hormonal factors in the comprehensive early treatment of infantile AD to prevent complications associated with electrolyte imbalances and nutritional deficiencies.<\/jats:p>","DOI":"10.6065\/apem.2550320.160","type":"journal-article","created":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T23:10:28Z","timestamp":1766963428000},"page":"247-252","update-policy":"https:\/\/doi.org\/10.6065\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Secondary hyperaldosteronism associated with severe infantile atopic dermatitis: a case series"],"prefix":"10.6065","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4922-1974","authenticated-orcid":true,"given":"Aim\u00e9e M.M.C.","family":"Jacquemot","sequence":"first","affiliation":[{"name":"Department of Paediatric Nephrology, Evelina Children\u2019s Hospital, Guy\u2019s and St Thomas\u2019 NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1385-3961","authenticated-orcid":true,"given":"David R.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Department of Clinical Biochemistry (Synnovis), Kings College Hospital NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4776-2653","authenticated-orcid":true,"given":"Nabil","family":"Melhem","sequence":"additional","affiliation":[{"name":"Department of Paediatric Nephrology, Evelina Children\u2019s Hospital, Guy\u2019s and St Thomas\u2019 NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1796-9136","authenticated-orcid":true,"given":"Emily","family":"Derrick","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, University Hospital Lewisham, Lewisham and Greenwich NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4335-2159","authenticated-orcid":true,"given":"Ritika R.","family":"Kapoor","sequence":"additional","affiliation":[{"name":"Faculty of Life Sciences and Medicine, King's College London, London, UK"},{"name":"Department of Paediatric Endocrinology, Variety Children's Hospital, King's College Hospital NHS Foundation Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"4096","reference":[{"key":"ref1","first-page":"489","type":"book","volume-title":"","author":"Stewart","year":"2016"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-008-0498-1","type":"journal-article"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159\/000449057","type":"journal-article"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/ped.13865","type":"journal-article"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/s0889-8529(18)30029-x","type":"journal-article"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.2500\/aap.2023.44.230010","type":"journal-article"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06541.x","type":"journal-article"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093\/ced\/llad080","type":"journal-article"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3038.2002.01041.x","type":"journal-article"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3345\/kjp.2018.06324","type":"journal-article"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.03.023","type":"journal-article"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2020-241057","type":"journal-article"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2004.05329.x","type":"journal-article"},{"key":"ref14","volume-title":"","author":"Gounden","type":"book"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00454.2003","type":"journal-article"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007\/s11845-023-03490-8","type":"journal-article"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.2298\/sarh1512748v","type":"journal-article"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-010-0930-4","type":"journal-article"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2021.773246","type":"journal-article"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00634.2020","type":"journal-article"}],"container-title":["Annals of Pediatric Endocrinology &amp; Metabolism"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/e-apem.org\/upload\/pdf\/apem-2550320-160.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/e-apem.org\/journal\/view.php?doi=10.6065\/apem.2550320.160","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/e-apem.org\/upload\/pdf\/apem-2550320-160.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T01:36:05Z","timestamp":1787880965000},"score":1,"resource":{"primary":{"URL":"http:\/\/e-apem.org\/journal\/view.php?doi=10.6065\/apem.2550320.160"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,31]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,8]]}},"URL":"https:\/\/doi.org\/10.6065\/apem.2550320.160","relation":{},"ISSN":["2287-1012","2287-1292"],"issn-type":[{"value":"2287-1012","type":"print"},{"value":"2287-1292","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,31]]},"assertion":[{"value":"2025-08-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-11-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-27","order":2,"name":"published","label":"Published online","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-31","order":3,"name":"published","label":"Print publication","group":{"name":"publication_history","label":"Publication History"}}]}}