{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T22:09:24Z","timestamp":1785881364185,"version":"3.56.0"},"reference-count":28,"publisher":"Genomic Press","issue":"1","license":[{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,5]]},"abstract":"<jats:p>\n                    <jats:bold>Microplastics and nanoplastics now contaminate every human compartment examined, including blood, placenta, atheromatous plaque, and brain tissue. The brain warrants particular attention. Decedent brain tissue has been shown to carry microplastic concentrations seven to thirty times higher than liver or kidney, with a 50% rise documented between 2016 and 2024, and the highest burdens observed in donors with diagnosed dementia. Animal data confirm that nanoscale particles cross the blood-brain barrier within hours of oral exposure. Ultra-processed foods, which now account for more than half of caloric intake in the United States, serve as high-throughput delivery vehicles for microplastics via packaging migration, mechanical processing, and contamination. They have themselves been independently linked in large prospective cohorts to depression, anxiety, cognitive decline, stroke, and dementia. The convergence of high tissue burden, biologically plausible mechanism, and a population-scale modifiable exposure vehicle defines a Brain Health emergency. We outline what is known, what is not yet measurable, and where the field must move next, with attention to vulnerable populations including pregnant women, children, and patients with established neurological or cardiovascular disease.<\/jats:bold>\n                  <\/jats:p>","DOI":"10.61373\/bh026p.0006","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T10:00:13Z","timestamp":1779184813000},"page":"12-15","source":"Crossref","is-referenced-by-count":1,"title":["The human microplastic burden and brain health: From measurement to pathophysiology and removal"],"prefix":"10.61373","volume":"1","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6905-5884","authenticated-orcid":true,"given":"Julio","family":"Licinio","sequence":"first","affiliation":[{"name":"Genomic Press, New York, New York 10036, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9635-4860","authenticated-orcid":true,"given":"Charlotte","family":"Steenblock","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, University Hospital Carl Gustav Carus, Technische Universit\u00e4t Dresden, 01307 Dresden, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6873-5105","authenticated-orcid":true,"given":"Nicholas","family":"Fabiano","sequence":"additional","affiliation":[{"name":"University of Ottawa, Department of Psychiatry, Ottawa, Ontario K1H 8L6, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5211-2536","authenticated-orcid":true,"given":"Stefan R.","family":"Bornstein","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, University Hospital Carl Gustav Carus, Technische Universit\u00e4t Dresden, 01307 Dresden, Germany"},{"name":"School of Cardiovascular and Metabolic Medicine and Sciences, Faculty of Life Sciences & Medicine, King's College London, London WC2R 2LS, UK"},{"name":"Department of Endocrinology, Diabetology and Clinical Nutrition, University Hospital Zurich (USZ) and University of Zurich (UZH), 8091 Zurich, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1512-3073","authenticated-orcid":true,"given":"Ma-Li","family":"Wong","sequence":"additional","affiliation":[{"name":"Genomic Press, New York, New York 10036, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"40195","reference":[{"issue":"3","key":"R1","series-title":"Brain Med","doi-asserted-by":"publisher","first-page":"1","DOI":"10.61373\/bm025g.0062","article-title":"Una cuchara de pl\u00e1stico en tu cerebro: the calamity of a plastic spoon in your brain","volume":"1","year":"2025","unstructured":"Wong M-L. 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