{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T23:59:35Z","timestamp":1778803175297,"version":"3.51.4"},"reference-count":48,"publisher":"Genomic Press","issue":"6","license":[{"start":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:00:00Z","timestamp":1762819200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,11,11]]},"abstract":"<jats:p>\n                    <jats:bold>Yue, Luo, and colleagues discovered that adenosine signalling is the common underlying mechanism of rapid acting antidepressant therapies, unifying the effects of ketamine, ECT and acute intermittent hypoxia. They use genetically encoded sensors, along with extensive mechanistic dissection, to show that all three induce adenosine surges in mood-regulatory circuits via A1 and A2A receptor activation. The mechanism of action of ketamine primarily involves modulation of mitochondrial metabolism as opposed to NMDA receptor antagonism, thereby presenting the possibility for improvements in derivative products with better therapeutic indices. These outcomes offers a rational framework for gauging therapeutic benefit for depression and raise vexing questions about patterns of caffeine consumption in treatment resistant depression, specifically whether the chronic use has a protective effect or whether the acute use impedes treatment response.<\/jats:bold>\n                  <\/jats:p>","DOI":"10.61373\/bm025c.0134","type":"journal-article","created":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:13:51Z","timestamp":1762866831000},"page":"18-23","source":"Crossref","is-referenced-by-count":3,"title":["Adenosine as the metabolic common path of rapid antidepressant action: The coffee paradox"],"prefix":"10.61373","volume":"1","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6905-5884","authenticated-orcid":true,"given":"Julio","family":"Licinio","sequence":"first","affiliation":[{"name":"Genomic Press, New York, New York 10036, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1512-3073","authenticated-orcid":true,"given":"Ma-Li","family":"Wong","sequence":"additional","affiliation":[{"name":"Genomic Press, New York, New York 10036, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"40195","reference":[{"key":"R1","series-title":"An introduction to the study of experimental medicine","first-page":"226","year":"1957","unstructured":"Bernard C. An introduction to the study of experimental medicine. New York: Dover Publications; 1957. 226 p."},{"key":"R2","series-title":"Nature","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-025-09755-9","article-title":"Adenosine signalling drives antidepressant actions of ketamine and ECT","year":"2025","unstructured":"Yue C, Wang N, Zhai H, Yuan Z, Cui Y, Quan J,  Adenosine signalling drives antidepressant actions of ketamine and ECT. Nature. 2025. DOI: 10.1038\/s41586-025-09755-9. PMID: 41193806"},{"issue":"9","key":"R3","series-title":"Neuropsychopharmacology","doi-asserted-by":"publisher","first-page":"1609","DOI":"10.1038\/npp.2013.71","article-title":"NMDA receptor blockade by ketamine abrogates lipopolysaccharide-induced depressive-like behavior in C57BL\/6J mice","volume":"38","year":"2013","unstructured":"Walker AK, Budac DP, Bisulco S, Lee AW, Smith RA, Beenders B,  NMDA receptor blockade by ketamine abrogates lipopolysaccharide-induced depressive-like behavior in C57BL\/6J mice. Neuropsychopharmacology. 2013;38(9):1609\u201316. DOI: 10.1038\/npp.2013.71. PMID: 23511700; PMCID: PMC3717543"},{"key":"R4","series-title":"Ann NY Acad Sci","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1111\/j.1749-6632.1995.tb44695.x","article-title":"Overview of neuroimmune stress interactions. Implications for susceptibility to inflammatory disease","volume":"771","year":"1995","unstructured":"Sternberg EM, Licinio J. Overview of neuroimmune stress interactions. Implications for susceptibility to inflammatory disease. Ann NY Acad Sci. 1995;771:364\u201371. DOI: 10.1111\/j.1749-6632.1995.tb44695.x. PMID: 8597414"},{"issue":"6","key":"R5","series-title":"Mol Psychiatry","doi-asserted-by":"publisher","first-page":"2475","DOI":"10.1038\/s41380-024-02851-8","article-title":"Astrocytes release ATP\/ADP and glutamate in flashes via vesicular exocytosis","volume":"30","year":"2025","unstructured":"Li H, Zhao Y, Dai R, Geng P, Weng D, Wu W,  Astrocytes release ATP\/ADP and glutamate in flashes via vesicular exocytosis. Mol Psychiatry. 2025;30(6):2475\u201389. DOI: 10.1038\/s41380-024-02851-8. PMID: 39578520"},{"issue":"18","key":"R6","series-title":"Psychopharmacology (Berl)","doi-asserted-by":"publisher","first-page":"3663","DOI":"10.1007\/s00213-014-3664-5","article-title":"Ketamine administration in depressive disorders: a systematic review and meta-analysis","volume":"231","year":"2014","unstructured":"Fond G, Loundou A, Rabu C, Macgregor A, Lancon C, Brittner M,  Ketamine administration in depressive disorders: a systematic review and meta-analysis. Psychopharmacology (Berl). 2014;231(18):3663\u201376. DOI: 10.1007\/s00213-014-3664-5. PMID: 25038867"},{"issue":"3","key":"R7","series-title":"Pharmacol Rev","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1124\/pr.117.015198","article-title":"Ketamine and Ketamine metabolite pharmacology: insights into therapeutic mechanisms","volume":"70","year":"2018","unstructured":"Zanos P, Moaddel R, Morris PJ, Riggs LM, Highland JN, Georgiou P,  Ketamine and Ketamine metabolite pharmacology: insights into therapeutic mechanisms. Pharmacol Rev. 2018;70(3):621\u201360. DOI: 10.1124\/pr.117.015198. PMID: 29945898; PMCID: PMC6020109"},{"issue":"7604","key":"R8","series-title":"Nature","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1038\/nature17998","article-title":"NMDAR inhibition-independent antidepressant actions of ketamine metabolites","volume":"533","year":"2016","unstructured":"Zanos P, Moaddel R, Morris PJ, Georgiou P, Fischell J, Elmer GI,  NMDAR inhibition-independent antidepressant actions of ketamine metabolites. Nature. 2016;533(7604):481\u20136. DOI: 10.1038\/nature17998. PMID: 27144355; PMCID: PMC4922311"},{"issue":"10","key":"R9","series-title":"Am J Physiol Regul Integr Comp Physiol","doi-asserted-by":"publisher","first-page":"R1181","DOI":"10.1152\/ajpregu.00208.2014","article-title":"Therapeutic potential of intermittent hypoxia: a matter of dose","volume":"307","year":"2014","unstructured":"Navarrete-Opazo A, Mitchell GS. Therapeutic potential of intermittent hypoxia: a matter of dose. Am J Physiol Regul Integr Comp Physiol. 2014;307(10):R1181\u201397. DOI: 10.1152\/ajpregu.00208.2014. PMID: 25231353; PMCID: PMC4315448"},{"key":"R10","series-title":"Biochem Pharmacol","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.bcp.2019.06.008","article-title":"The physiological effects of caffeine on synaptic transmission and plasticity in the mouse hippocampus selectively depend on adenosine A1 and A2A receptors","volume":"166","year":"2019","unstructured":"Lopes JP, Pli\u00e1ssova A, Cunha RA. The physiological effects of caffeine on synaptic transmission and plasticity in the mouse hippocampus selectively depend on adenosine A1 and A2A receptors. Biochem Pharmacol. 2019;166:313\u201321. DOI: 10.1016\/j.bcp.2019.06.008. PMID: 31199895"},{"issue":"1","key":"R11","series-title":"Pharmacol Rev","first-page":"83","article-title":"Actions of caffeine in the brain with special reference to factors that contribute to its widespread use","volume":"51","year":"1999","unstructured":"Fredholm BB, B\u00e4ttig K, Holm\u00e9n J, Nehlig A, Zvartau EE. Actions of caffeine in the brain with special reference to factors that contribute to its widespread use. Pharmacol Rev. 1999;51(1):83\u2013133. PMID: 10049999"},{"issue":"3","key":"R12","series-title":"Aust N Z J Psychiatry","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1177\/0004867415603131","article-title":"Coffee and caffeine consumption and depression: A meta-analysis of observational studies","volume":"50","year":"2016","unstructured":"Wang L, Shen X, Wu Y, Zhang D. Coffee and caffeine consumption and depression: A meta-analysis of observational studies. Aust N Z J Psychiatry. 2016;50(3):228\u201342. DOI: 10.1177\/0004867415603131. PMID: 26339067"},{"issue":"1","key":"R13","series-title":"Mol Nutr Food Res","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1002\/mnfr.201500620","article-title":"Coffee, tea, caffeine and risk of depression: A systematic review and dose-response meta-analysis of observational studies","volume":"60","year":"2016","unstructured":"Grosso G, Micek A, Castellano S, Pajak A, Galvano F. Coffee, tea, caffeine and risk of depression: A systematic review and dose-response meta-analysis of observational studies. Mol Nutr Food Res. 2016;60(1):223\u201334. DOI: 10.1002\/mnfr.201500620. PMID: 26518745"},{"issue":"1","key":"R14","series-title":"J Pharmacol Exp Ther","first-page":"62","article-title":"Role of adenosine receptors in caffeine tolerance","volume":"256","year":"1991","unstructured":"Holtzman SG, Mante S, Minneman KP. Role of adenosine receptors in caffeine tolerance. J Pharmacol Exp Ther. 1991;256(1):62\u20138. PMID: 1846425"},{"issue":"5","key":"R15","series-title":"Mol Pharmacol","first-page":"886","article-title":"Inverse agonists and neutral antagonists of recombinant human A1 adenosine receptors stably expressed in Chinese hamster ovary cells","volume":"53","year":"1998","unstructured":"Shryock JC, Ozeck MJ, Belardinelli L. Inverse agonists and neutral antagonists of recombinant human A1 adenosine receptors stably expressed in Chinese hamster ovary cells. Mol Pharmacol. 1998;53(5):886\u201393. PMID: 9584215"},{"issue":"7","key":"R16","series-title":"Circulation","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1161\/01.cir.98.7.711","article-title":"A2A-adenosine receptor reserve for coronary vasodilation","volume":"98","year":"1998","unstructured":"Shryock JC, Snowdy S, Baraldi PG, Cacciari B, Spalluto G, Monopoli A,  A2A-adenosine receptor reserve for coronary vasodilation. Circulation. 1998;98(7):711\u20138. DOI: 10.1161\/01.cir.98.7.711. PMID: 9715864"},{"issue":"4","key":"R17","series-title":"Mov Disord","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1002\/mds.28897","article-title":"Adenosine A2A receptor occupancy by caffeine after coffee intake in Parkinson's disease","volume":"37","year":"2022","unstructured":"Ishibashi K, Miura Y, Wagatsuma K, Toyohara J, Ishiwata K, Ishii K. Adenosine A2A receptor occupancy by caffeine after coffee intake in Parkinson's disease. Mov Disord. 2022;37(4):853\u20137. DOI: 10.1002\/mds.28897. PMID: 35001424; PMCID: PMC9306703"},{"key":"R18","series-title":"Neuropharmacology","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.neuropharm.2015.10.034","article-title":"BDNF \u2013 a key transducer of antidepressant effects","volume":"102","year":"2016","unstructured":"Bj\u00f6rkholm C, Monteggia LM. BDNF \u2013 a key transducer of antidepressant effects. Neuropharmacology. 2016;102:72\u20139. DOI: 10.1016\/j.neuropharm.2015.10.034. PMID: 26519901; PMCID: PMC4763983"},{"issue":"3","key":"R19","series-title":"Neuron","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/j.neuron.2015.07.010","article-title":"Increased signaling via adenosine A1 receptors, sleep deprivation, imipramine, and ketamine inhibit depressive-like behavior via induction of Homer1a","volume":"87","year":"2015","unstructured":"Serchov T, Clement HW, Schwarz MK, Iasevoli F, Tosh DK, Idzko M,  Increased signaling via adenosine A1 receptors, sleep deprivation, imipramine, and ketamine inhibit depressive-like behavior via induction of Homer1a. Neuron. 2015;87(3):549\u201362. DOI: 10.1016\/j.neuron.2015.07.010. PMID: 26247862; PMCID: PMC4803038"},{"issue":"5994","key":"R20","series-title":"Science","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1126\/science.1190287","article-title":"mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists","volume":"329","year":"2010","unstructured":"Li N, Lee B, Liu RJ, Banasr M, Dwyer JM, Iwata M,  mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists. Science. 2010;329(5994):959\u201364. DOI: 10.1126\/science.1190287. PMID: 20724638; PMCID: PMC3116441"},{"issue":"4","key":"R21","series-title":"Biol Psychiatry","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/s0006-3223(99)00230-9","article-title":"Antidepressant effects of ketamine in depressed patients","volume":"47","year":"2000","unstructured":"Berman RM, Cappiello A, Anand A, Oren DA, Heninger GR, Charney DS,  Antidepressant effects of ketamine in depressed patients. Biol Psychiatry. 2000;47(4):351\u20134. DOI: 10.1016\/s0006-3223(99)00230-9. PMID: 10686270"},{"issue":"7354","key":"R22","series-title":"Nature","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1038\/nature10130","article-title":"NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses","volume":"475","year":"2011","unstructured":"Autry AE, Adachi M, Nosyreva E, Na ES, Los MF, Cheng PF,  NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses. Nature. 2011;475(7354):91\u20135. DOI: 10.1038\/nature10130. PMID: 21677641; PMCID: PMC3172695"},{"issue":"3","key":"R23","series-title":"Nat Med","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1038\/nm.4050","article-title":"Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants","volume":"22","year":"2016","unstructured":"Duman RS, Aghajanian GK, Sanacora G, Krystal JH. Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants. Nat Med. 2016;22(3):238\u201349. DOI: 10.1038\/nm.4050. PMID: 26937618; PMCID: PMC5405628"},{"key":"R24","series-title":"Simulacra and simulation","first-page":"164","year":"1994","unstructured":"Baudrillard J. Simulacra and simulation. Ann Arbor: University of Michigan Press; 1994. 164 p."},{"key":"R1","series-title":"An introduction to the study of experimental medicine","first-page":"226","year":"1957","unstructured":"Bernard C. An introduction to the study of experimental medicine. New York: Dover Publications; 1957. 226 p."},{"key":"R2","series-title":"Nature","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-025-09755-9","article-title":"Adenosine signalling drives antidepressant actions of ketamine and ECT","year":"2025","unstructured":"Yue C, Wang N, Zhai H, Yuan Z, Cui Y, Quan J,  Adenosine signalling drives antidepressant actions of ketamine and ECT. Nature. 2025. DOI: 10.1038\/s41586-025-09755-9. PMID: 41193806"},{"issue":"9","key":"R3","series-title":"Neuropsychopharmacology","doi-asserted-by":"publisher","first-page":"1609","DOI":"10.1038\/npp.2013.71","article-title":"NMDA receptor blockade by ketamine abrogates lipopolysaccharide-induced depressive-like behavior in C57BL\/6J mice","volume":"38","year":"2013","unstructured":"Walker AK, Budac DP, Bisulco S, Lee AW, Smith RA, Beenders B,  NMDA receptor blockade by ketamine abrogates lipopolysaccharide-induced depressive-like behavior in C57BL\/6J mice. Neuropsychopharmacology. 2013;38(9):1609\u201316. DOI: 10.1038\/npp.2013.71. PMID: 23511700; PMCID: PMC3717543"},{"key":"R4","series-title":"Ann NY Acad Sci","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1111\/j.1749-6632.1995.tb44695.x","article-title":"Overview of neuroimmune stress interactions. Implications for susceptibility to inflammatory disease","volume":"771","year":"1995","unstructured":"Sternberg EM, Licinio J. Overview of neuroimmune stress interactions. Implications for susceptibility to inflammatory disease. Ann NY Acad Sci. 1995;771:364\u201371. DOI: 10.1111\/j.1749-6632.1995.tb44695.x. PMID: 8597414"},{"issue":"6","key":"R5","series-title":"Mol Psychiatry","doi-asserted-by":"publisher","first-page":"2475","DOI":"10.1038\/s41380-024-02851-8","article-title":"Astrocytes release ATP\/ADP and glutamate in flashes via vesicular exocytosis","volume":"30","year":"2025","unstructured":"Li H, Zhao Y, Dai R, Geng P, Weng D, Wu W,  Astrocytes release ATP\/ADP and glutamate in flashes via vesicular exocytosis. Mol Psychiatry. 2025;30(6):2475\u201389. DOI: 10.1038\/s41380-024-02851-8. PMID: 39578520"},{"issue":"18","key":"R6","series-title":"Psychopharmacology (Berl)","doi-asserted-by":"publisher","first-page":"3663","DOI":"10.1007\/s00213-014-3664-5","article-title":"Ketamine administration in depressive disorders: a systematic review and meta-analysis","volume":"231","year":"2014","unstructured":"Fond G, Loundou A, Rabu C, Macgregor A, Lancon C, Brittner M,  Ketamine administration in depressive disorders: a systematic review and meta-analysis. Psychopharmacology (Berl). 2014;231(18):3663\u201376. DOI: 10.1007\/s00213-014-3664-5. PMID: 25038867"},{"issue":"3","key":"R7","series-title":"Pharmacol Rev","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1124\/pr.117.015198","article-title":"Ketamine and Ketamine metabolite pharmacology: insights into therapeutic mechanisms","volume":"70","year":"2018","unstructured":"Zanos P, Moaddel R, Morris PJ, Riggs LM, Highland JN, Georgiou P,  Ketamine and Ketamine metabolite pharmacology: insights into therapeutic mechanisms. Pharmacol Rev. 2018;70(3):621\u201360. DOI: 10.1124\/pr.117.015198. PMID: 29945898; PMCID: PMC6020109"},{"issue":"7604","key":"R8","series-title":"Nature","doi-asserted-by":"publisher","first-page":"481","DOI":"10.1038\/nature17998","article-title":"NMDAR inhibition-independent antidepressant actions of ketamine metabolites","volume":"533","year":"2016","unstructured":"Zanos P, Moaddel R, Morris PJ, Georgiou P, Fischell J, Elmer GI,  NMDAR inhibition-independent antidepressant actions of ketamine metabolites. Nature. 2016;533(7604):481\u20136. DOI: 10.1038\/nature17998. PMID: 27144355; PMCID: PMC4922311"},{"issue":"10","key":"R9","series-title":"Am J Physiol Regul Integr Comp Physiol","doi-asserted-by":"publisher","first-page":"R1181","DOI":"10.1152\/ajpregu.00208.2014","article-title":"Therapeutic potential of intermittent hypoxia: a matter of dose","volume":"307","year":"2014","unstructured":"Navarrete-Opazo A, Mitchell GS. Therapeutic potential of intermittent hypoxia: a matter of dose. Am J Physiol Regul Integr Comp Physiol. 2014;307(10):R1181\u201397. DOI: 10.1152\/ajpregu.00208.2014. PMID: 25231353; PMCID: PMC4315448"},{"key":"R10","series-title":"Biochem Pharmacol","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1016\/j.bcp.2019.06.008","article-title":"The physiological effects of caffeine on synaptic transmission and plasticity in the mouse hippocampus selectively depend on adenosine A1 and A2A receptors","volume":"166","year":"2019","unstructured":"Lopes JP, Pli\u00e1ssova A, Cunha RA. The physiological effects of caffeine on synaptic transmission and plasticity in the mouse hippocampus selectively depend on adenosine A1 and A2A receptors. Biochem Pharmacol. 2019;166:313\u201321. DOI: 10.1016\/j.bcp.2019.06.008. PMID: 31199895"},{"issue":"1","key":"R11","series-title":"Pharmacol Rev","first-page":"83","article-title":"Actions of caffeine in the brain with special reference to factors that contribute to its widespread use","volume":"51","year":"1999","unstructured":"Fredholm BB, B\u00e4ttig K, Holm\u00e9n J, Nehlig A, Zvartau EE. Actions of caffeine in the brain with special reference to factors that contribute to its widespread use. Pharmacol Rev. 1999;51(1):83\u2013133. PMID: 10049999"},{"issue":"3","key":"R12","series-title":"Aust N Z J Psychiatry","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1177\/0004867415603131","article-title":"Coffee and caffeine consumption and depression: A meta-analysis of observational studies","volume":"50","year":"2016","unstructured":"Wang L, Shen X, Wu Y, Zhang D. Coffee and caffeine consumption and depression: A meta-analysis of observational studies. Aust N Z J Psychiatry. 2016;50(3):228\u201342. DOI: 10.1177\/0004867415603131. PMID: 26339067"},{"issue":"1","key":"R13","series-title":"Mol Nutr Food Res","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1002\/mnfr.201500620","article-title":"Coffee, tea, caffeine and risk of depression: A systematic review and dose-response meta-analysis of observational studies","volume":"60","year":"2016","unstructured":"Grosso G, Micek A, Castellano S, Pajak A, Galvano F. Coffee, tea, caffeine and risk of depression: A systematic review and dose-response meta-analysis of observational studies. Mol Nutr Food Res. 2016;60(1):223\u201334. DOI: 10.1002\/mnfr.201500620. PMID: 26518745"},{"issue":"1","key":"R14","series-title":"J Pharmacol Exp Ther","first-page":"62","article-title":"Role of adenosine receptors in caffeine tolerance","volume":"256","year":"1991","unstructured":"Holtzman SG, Mante S, Minneman KP. Role of adenosine receptors in caffeine tolerance. J Pharmacol Exp Ther. 1991;256(1):62\u20138. PMID: 1846425"},{"issue":"5","key":"R15","series-title":"Mol Pharmacol","first-page":"886","article-title":"Inverse agonists and neutral antagonists of recombinant human A1 adenosine receptors stably expressed in Chinese hamster ovary cells","volume":"53","year":"1998","unstructured":"Shryock JC, Ozeck MJ, Belardinelli L. Inverse agonists and neutral antagonists of recombinant human A1 adenosine receptors stably expressed in Chinese hamster ovary cells. Mol Pharmacol. 1998;53(5):886\u201393. PMID: 9584215"},{"issue":"7","key":"R16","series-title":"Circulation","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1161\/01.cir.98.7.711","article-title":"A2A-adenosine receptor reserve for coronary vasodilation","volume":"98","year":"1998","unstructured":"Shryock JC, Snowdy S, Baraldi PG, Cacciari B, Spalluto G, Monopoli A,  A2A-adenosine receptor reserve for coronary vasodilation. Circulation. 1998;98(7):711\u20138. DOI: 10.1161\/01.cir.98.7.711. PMID: 9715864"},{"issue":"4","key":"R17","series-title":"Mov Disord","doi-asserted-by":"publisher","first-page":"853","DOI":"10.1002\/mds.28897","article-title":"Adenosine A2A receptor occupancy by caffeine after coffee intake in Parkinson's disease","volume":"37","year":"2022","unstructured":"Ishibashi K, Miura Y, Wagatsuma K, Toyohara J, Ishiwata K, Ishii K. Adenosine A2A receptor occupancy by caffeine after coffee intake in Parkinson's disease. Mov Disord. 2022;37(4):853\u20137. DOI: 10.1002\/mds.28897. PMID: 35001424; PMCID: PMC9306703"},{"key":"R18","series-title":"Neuropharmacology","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1016\/j.neuropharm.2015.10.034","article-title":"BDNF \u2013 a key transducer of antidepressant effects","volume":"102","year":"2016","unstructured":"Bj\u00f6rkholm C, Monteggia LM. BDNF \u2013 a key transducer of antidepressant effects. Neuropharmacology. 2016;102:72\u20139. DOI: 10.1016\/j.neuropharm.2015.10.034. PMID: 26519901; PMCID: PMC4763983"},{"issue":"3","key":"R19","series-title":"Neuron","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1016\/j.neuron.2015.07.010","article-title":"Increased signaling via adenosine A1 receptors, sleep deprivation, imipramine, and ketamine inhibit depressive-like behavior via induction of Homer1a","volume":"87","year":"2015","unstructured":"Serchov T, Clement HW, Schwarz MK, Iasevoli F, Tosh DK, Idzko M,  Increased signaling via adenosine A1 receptors, sleep deprivation, imipramine, and ketamine inhibit depressive-like behavior via induction of Homer1a. Neuron. 2015;87(3):549\u201362. DOI: 10.1016\/j.neuron.2015.07.010. PMID: 26247862; PMCID: PMC4803038"},{"issue":"5994","key":"R20","series-title":"Science","doi-asserted-by":"publisher","first-page":"959","DOI":"10.1126\/science.1190287","article-title":"mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists","volume":"329","year":"2010","unstructured":"Li N, Lee B, Liu RJ, Banasr M, Dwyer JM, Iwata M,  mTOR-dependent synapse formation underlies the rapid antidepressant effects of NMDA antagonists. Science. 2010;329(5994):959\u201364. DOI: 10.1126\/science.1190287. PMID: 20724638; PMCID: PMC3116441"},{"issue":"4","key":"R21","series-title":"Biol Psychiatry","doi-asserted-by":"publisher","first-page":"351","DOI":"10.1016\/s0006-3223(99)00230-9","article-title":"Antidepressant effects of ketamine in depressed patients","volume":"47","year":"2000","unstructured":"Berman RM, Cappiello A, Anand A, Oren DA, Heninger GR, Charney DS,  Antidepressant effects of ketamine in depressed patients. Biol Psychiatry. 2000;47(4):351\u20134. DOI: 10.1016\/s0006-3223(99)00230-9. PMID: 10686270"},{"issue":"7354","key":"R22","series-title":"Nature","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1038\/nature10130","article-title":"NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses","volume":"475","year":"2011","unstructured":"Autry AE, Adachi M, Nosyreva E, Na ES, Los MF, Cheng PF,  NMDA receptor blockade at rest triggers rapid behavioural antidepressant responses. Nature. 2011;475(7354):91\u20135. DOI: 10.1038\/nature10130. PMID: 21677641; PMCID: PMC3172695"},{"issue":"3","key":"R23","series-title":"Nat Med","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1038\/nm.4050","article-title":"Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants","volume":"22","year":"2016","unstructured":"Duman RS, Aghajanian GK, Sanacora G, Krystal JH. Synaptic plasticity and depression: new insights from stress and rapid-acting antidepressants. Nat Med. 2016;22(3):238\u201349. DOI: 10.1038\/nm.4050. PMID: 26937618; PMCID: PMC5405628"},{"key":"R24","series-title":"Simulacra and simulation","first-page":"164","year":"1994","unstructured":"Baudrillard J. Simulacra and simulation. Ann Arbor: University of Michigan Press; 1994. 164 p."}],"container-title":["Brain Medicine"],"original-title":[],"link":[{"URL":"https:\/\/genomicpress.kglmeridian.com\/view\/journals\/brainmed\/1\/6\/article-p18.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/genomicpress.kglmeridian.com\/downloadpdf\/journals\/brainmed\/1\/6\/article-p18.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/genomicpress.kglmeridian.com\/downloadpdf\/journals\/brainmed\/1\/6\/article-p18.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T00:51:31Z","timestamp":1770771091000},"score":1,"resource":{"primary":{"URL":"https:\/\/genomicpress.kglmeridian.com\/view\/journals\/brainmed\/1\/6\/article-p18.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,11]]},"references-count":48,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.61373\/bm025c.0134","relation":{},"ISSN":["2997-2647","2997-2639"],"issn-type":[{"value":"2997-2647","type":"print"},{"value":"2997-2639","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,11]]}}}