{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T00:54:45Z","timestamp":1781744085669,"version":"3.54.5"},"reference-count":16,"publisher":"Genomic Press","license":[{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,9]]},"abstract":"<jats:p>\n                    <jats:bold>PHF21B is an epigenetic reader that modulates synaptic plasticity-related genes and social memory (1). Although PHF21B is known to bind H3K36me3, the domain responsible for this interaction has remained uncharacterized. Here, we used co-immunoprecipitation with PHF21B deletion mutants in HEK293T cells to show that the PHD-zinc finger domain is essential for H3K36me3 recognition, whereas the C-terminal coiled-coil region is dispensable. These findings identify the PHD-zinc finger domain as the critical H3K36me3-binding module of PHF21B, with implications for neurological disorders linked to chromosome 22q13.3 deletion, including Phelan-McDermid syndrome (2, 3)<\/jats:bold>\n                    .\n                  <\/jats:p>","DOI":"10.61373\/gp026l.0042","type":"journal-article","created":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T10:19:01Z","timestamp":1781000341000},"page":"1-2","source":"Crossref","is-referenced-by-count":0,"title":["A PHD-zinc finger-mediated mechanism for PHF21B recognition of H3K36me3"],"prefix":"10.61373","author":[{"given":"Q.","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, College of Medicine, State University of New York, Upstate Medical University, Syracuse, NY 13210, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Licinio","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, College of Medicine, State University of New York, Upstate Medical University, Syracuse, NY 13210, USA"},{"name":"Department of Neuroscience & Physiology, College of Medicine, State University of New York, Upstate Medical University, Syracuse, NY 13210, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.L.","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Behavioral Sciences, College of Medicine, State University of New York, Upstate Medical University, Syracuse, NY 13210, USA"},{"name":"Department of Neuroscience & Physiology, College of Medicine, State University of New York, Upstate Medical University, Syracuse, NY 13210, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"40195","reference":[{"issue":"14","key":"R1","series-title":"JCI Insight","doi-asserted-by":"publisher","first-page":"e158081","DOI":"10.1172\/jci.insight.158081","article-title":"The epigenetic reader PHF21B modulates murine social memory and synaptic plasticity-related genes","volume":"7","year":"2022","unstructured":"Chin EWM, Ma Q, Ruan H, Chin C, Somasundaram A, Zhang C,  The epigenetic reader PHF21B modulates murine social memory and synaptic plasticity-related genes. 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