{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T12:30:26Z","timestamp":1786710626925,"version":"build-2736575974"},"reference-count":19,"publisher":"Danish Medical Association","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dan Med J"],"abstract":"<jats:p>INTRODUCTION. Chemosensory dysfunction (CD), particularly olfactory and gustatory dysfunction, is a common symptom of SARS-CoV-2 infection. While often transient, some patients develop persistent dysfunction. The long-term relationship between persistent CD, long COVID (LC) and quality of life (QoL) remains unclear. This study aimed to evaluate CD recovery four years after infection and its association with LC symptoms and QoL.\n\nMETHODS. In this prospective cohort study, 356 individuals with sudden CD during the COVID-19 pandemic completed a questionnaire four years after symptom onset. The survey assessed CD recovery, LC symptoms and QoL using validated self-report items. Outcomes were compared between participants with recovered versus persistent CD. The study followed the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) guidelines.\n\nRESULTS. Only 43% reported full recovery of CD after four years. Persistent dysfunction was most common among participants aged 45-59 years (68%). Participants with persistent CD were significantly more likely to report LC symptoms, particularly fatigue (OR = 4.33), memory difficulties (OR = 3.30) and insomnia (OR = 3.39), each affecting more than 30% of this group. QoL scores indicated a greater impact on physical than emotional well-being.\n\nCONCLUSIONS. A substantial proportion of respondents continued to experience CD and other LC symptoms four years after infection. These findings highlight the need for long-term clinical awareness and further research on post-viral CD.\n\nFUNDING. None.\n\nTRIAL REGISTRATION. Not relevant.<\/jats:p>","DOI":"10.61409\/a01260014","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T10:41:43Z","timestamp":1783075303000},"page":"1-8","source":"Crossref","is-referenced-by-count":0,"title":["Patient burden of chemosensory dysfunction and long COVID"],"prefix":"10.61409","author":[{"given":"Joachim Skovgaard","family":"Hansen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Rohde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander Wieck","family":"Fjaeldstad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"40208","published-online":{"date-parts":[[2016,6]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"Desiato VM, Levy DA, Byun YJ, et al. The prevalence of olfactory dysfunction in the general population: a systematic review and meta-analysis. Am J Rhinol Allergy. 2021;35(2):195-205. https:\/\/doi.org\/10.1177\/1945892420946254","DOI":"10.1177\/1945892420946254"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"N\u00f8rgaard HJ, Fjaeldstad AW. Differences in correlation between subjective and measured olfactory and gustatory dysfunctions after initial ear, nose and throat evaluation. Int Arch Otorhinolaryngol. 2021;25(4):e563-e569. https:\/\/doi.org\/10.1055\/s-0040-1722249","DOI":"10.1055\/s-0040-1722249"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"Gerkin RC, Ohla K, Veldhuizen MG, et al. Recent smell loss is the best predictor of COVID-19 among individuals with recent respiratory symptoms. Chem Senses. 2021;46:bjaa081. https:\/\/doi.org\/10.1093\/chemse\/bjaa081","DOI":"10.1093\/chemse\/bjaa081"},{"key":"ref3","unstructured":"NHS. 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ORL J Otorhinolaryngol Relat Spec. 2021;83(4):209-218. https:\/\/doi.org\/10.1159\/000515132","DOI":"10.1159\/000515132"},{"key":"ref7","unstructured":"Schwab J, Fjaeldstad AW. Recovery rates and parosmia in olfactory loss during the COVID-19 era. Dan Med J. 2022;69(9):A04220271"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"Ghadirzadeh E, Davoodi L, Khazaei F, Taheri A. Spontaneous recovery of anosmia after 2.5 years in a young COVID-19 patient. Eur Clin Respir J. 2023;10(1):2178598. https:\/\/doi.org\/10.1080\/20018525.2023.2178598","DOI":"10.1080\/20018525.2023.2178598"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"Gorelik D, Dhanda AK, Khan NS, et al. Disparities in seeking care for olfactory and gustatory dysfunction: a population analysis. Int Forum Allergy Rhinol. 2024;14(10):1582-1589. https:\/\/doi.org\/10.1002\/alr.23390","DOI":"10.1002\/alr.23390"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"Boscolo-Rizzo P, Spinato G, Hopkins C, et al. Evaluating long-term smell or taste dysfunction in mildly symptomatic COVID-19 patients: a 3-year follow-up study. Eur Arch Otorhinolaryngol. 2023;280(12):5625-5630. https:\/\/doi.org\/10.1007\/s00405-023-08227-y","DOI":"10.1007\/s00405-023-08227-y"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"Saniasiaya J, Islam MA, Abdullah B. Prevalence of olfactory dysfunction in coronavirus disease 2019 (COVID-19): a meta-analysis of 27,492 patients. Laryngoscope. 2021;131(4):865-878. https:\/\/doi.org\/10.1002\/lary.29286","DOI":"10.1002\/lary.29286"},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"Terai H, Ishii M, Takemura R, et al. Comprehensive analysis of long COVID in a Japanese nationwide prospective cohort study. Respir Investig. 2023;61(6):802-814. https:\/\/doi.org\/10.1016\/j.resinv.2023.08.008","DOI":"10.1016\/j.resinv.2023.08.008"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"Dias M, Shaida Z, Haloob N, Hopkins C. Recovery rates and long-term olfactory dysfunction following COVID-19 infection. World J Otorhinolaryngol Head Neck Surg. 2024;10(2):121-128. https:\/\/doi.org\/10.1002\/wjo2.163","DOI":"10.1002\/wjo2.163"},{"key":"ref14","unstructured":"Fjaeldstad AW. Prolonged complaints of chemosensory loss after COVID-19. Dan Med J. 2020;67(8):A05200340"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"Byambasuren O, Stehlik P, Clark J, et al. Effect of covid-19 vaccination on long covid: systematic review. BMJ Med. 2023;2(1):e000385. https:\/\/doi.org\/10.1136\/bmjmed-2022-000385","DOI":"10.1136\/bmjmed-2022-000385"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"Boscolo-Rizzo P, Hummel T, Menini A, et al. Adherence to olfactory training improves orthonasal and retronasal olfaction in post-COVID-19 olfactory loss. Rhinology. 2024;62(6):734-742. https:\/\/doi.org\/10.4193\/rhin24.233","DOI":"10.4193\/Rhin24.233"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"Fjaeldstad AW. Culinary cure? Improved subjective and measured sense of smell after a cooking rehabilitation program for patients with smell loss. Int J Gastr Food Sci. 2025;39:101121. https:\/\/doi.org\/10.1016\/j.ijgfs.2025.101121","DOI":"10.1016\/j.ijgfs.2025.101121"},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"Murphy C, Dalton P, Boateng K, et al. Integrating the patient's voice into the research agenda for treatment of chemosensory disorders. 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