{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T23:33:16Z","timestamp":1761175996392,"version":"build-2065373602"},"reference-count":20,"publisher":"Danish Medical Association","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dan Med J"],"abstract":"<jats:p>INTRODUCTION. Erysipelas is a common disease in the emergency department, whereas necrotising soft tissue infections (NSTIs) are rare but more severe. The study aimed to investigate the prevalence, incidence, population-based incidence rate, one-year mortality and clinical presentation of erysipelas and NSTIs, and the aetiology, treatment and recurrence of erysipelas.\n\nMETHODS. This was a population-based cohort study including acute non-trauma patients \u2265 18 years old with erysipelas or NSTIs from the Region of Southern Denmark in the period from 1 January 2016 to 19 March 2018.\n\nRESULTS. Among 223,618 acute non-trauma visits, 2,136 had erysipelas (prevalence 1%), and 20 had NSTIs (prevalence 0.01%), 96.7 and 0.89 per 10,000 visits, respectively. The population-based incidence rates were 72.10 per 100,000 person-years for incident cases of erysipelas and 0.94 for NSTIs. One-year mortality was 15% for erysipelas and 25% for NSTIs. Erysipelas and NSTI patients had similar demographics and vital signs. For erysipelas, the predominant pathogen in blood cultures was Streptococcus dysgalactiae, with two-thirds of patients treated with narrow-spectrum penicillin. One-third of the erysipelas patients had a prior hospitalisation for the condition, and 7.7% of incident cases had recurrence within one year. Obesity and liver disease were risk factors for recurrence.\n\nCONCLUSIONS. Erysipelas is a common infection in the emergency department, whereas NSTIs are much rarer but also more severe and, at presentation, not distinctive in clinical parameters, which underlines the importance of clinical judgement.\n\nFUNDING. None.\n\nTRIAL REGISTRATION. Not relevant.<\/jats:p>","DOI":"10.61409\/a02250077","type":"journal-article","created":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T12:32:36Z","timestamp":1756902756000},"page":"1-10","source":"Crossref","is-referenced-by-count":0,"title":["Epidemiology of erysipelas and necrotising soft tissue infections"],"prefix":"10.61409","author":[{"given":"Agnete H. Rosengaard","family":"Tang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annmarie Touborg","family":"Lassen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"elene","family":"Skj\u00f8t-Arkil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isik Somuncu","family":"Johansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flemming Sch\u00f8nning","family":"Rosenvinge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael Dan","family":"Arvig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"40208","published-online":{"date-parts":[[2025,8]]},"reference":[{"key":"ref0","unstructured":"Sunderk\u00f6tter C, Becker K, Eckmann C, et al. Calculated initial parenteral treatment of bacterial infections: skin and soft tissue infections. GMS Infect Dis. 2020;8:Doc11. https:\/\/doi.org\/10.3205\/id000055"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Goettsch WG, Bavinck JNB, Herings RMC. Burden of illness of bacterial cellulitis and erysipelas of the leg in the Netherlands. J Eur Acad Dermatol Venereol. 2006;20(7):834-839. https:\/\/doi.org\/10.1111\/j.1468-3083.2006.01657.x","DOI":"10.1111\/j.1468-3083.2006.01657.x"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"So\u010dan K, So\u010dan M. Trends in the epidemiology of erysipelas in Slovenia. Acta Dermatovenerol Alp Pannonica Adriat. 2018;27(1):1-4","DOI":"10.15570\/actaapa.2018.1"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"Ren Z, Silverberg JI. Burden, risk factors, and infectious complications of cellulitis and erysipelas in US adults and children in the emergency department setting. J Am Acad Dermatol. 2021;84(5):1496-1503. https:\/\/doi.org\/10.1016\/j.jaad.2020.11.021","DOI":"10.1016\/j.jaad.2020.11.021"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"Krasagakis K, Valachis A, Maniatakis P, et al. Analysis of epidemiology, clinical features and management of erysipelas. Int J Dermatol. 2010;49(9):1012-1017. https:\/\/doi.org\/10.1111\/j.1365-4632.2010.04464.x","DOI":"10.1111\/j.1365-4632.2010.04464.x"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"Wu KH, Wu PH, Chang CY, et al. Differentiating necrotizing soft tissue infections from cellulitis by soft tissue infectious fluid analysis: a pilot study. World J Emerg Surg. 2022;17(1):1. https:\/\/doi.org\/10.1186\/s13017-022-00404-4","DOI":"10.1186\/s13017-022-00404-4"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"Wu KH, Chang CP. Differentiating lower extremity necrotizing soft tissue infection from severe cellulitis by laboratory parameters and relevant history points. Infect Drug Resist. 2021;14:3563-3569. https:\/\/doi.org\/10.2147\/IDR.S327880","DOI":"10.2147\/IDR.S327880"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"Collazos J, de la Fuente B, Garc\u00eda A, et al. Cellulitis in adult patients: a large, multicenter, observational, prospective study of 606 episodes and analysis of the factors related to the response to treatment. PLoS One. 2018;13(9):e0204036. https:\/\/doi.org\/10.1371\/journal.pone.0204036","DOI":"10.1371\/journal.pone.0204036"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"Inghammar M, Rasmussen M, Linder A. Recurrent erysipelas - risk factors and clinical presentation. BMC Infect Dis. 2014;14:270. https:\/\/doi.org\/10.1186\/1471-2334-14-270","DOI":"10.1186\/1471-2334-14-270"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"Bl\u00e4ckberg A, Trell K, Rasmussen M. Erysipelas, a large retrospective study of aetiology and clinical presentation. BMC Infect Dis. 2015;15:402. https:\/\/doi.org\/10.1186\/s12879-015-1134-2","DOI":"10.1186\/s12879-015-1134-2"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"Trell K, Rign\u00e9r S, Wierzbicka M, et al. Colonization of \u03b2-hemolytic streptococci in patients with erysipelas - a prospective study. Eur J Clin Microbiol Infect Dis. 2019;38(10):1901-1906. https:\/\/doi.org\/10.1007\/s10096-019-03625-9","DOI":"10.1007\/s10096-019-03625-9"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"Vandenbroucke JP, von Elm E, Altman DG, et al. Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): explanation and elaboration. Ann Intern Med. 2007;147(8):W163-W194. https:\/\/doi.org\/10.7326\/0003-4819-147-8-200710160-00010-w1","DOI":"10.7326\/0003-4819-147-8-200710160-00010-w1"},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"Arvig MD, Mogensen CB, Skj\u00f8t-Arkil H, et al. Chief complaints, underlying diagnoses, and mortality in adult, non-trauma emergency department visits: a population-based, multi-center cohort study. West J Emerg Med. 2022;23(6):855-863. https:\/\/doi.org\/10.5811\/westjem.2022.9.56332","DOI":"10.5811\/westjem.2022.9.56332"},{"key":"ref13","unstructured":"European Union. Regulation (EU) 2016\/679 of the European Parliament and of the Council of 27 April 2016 on the protection of natural persons with regard to the processing of personal data and on the free movement of such data, and repealing Directive 95\/46\/EC (General Data Protection Regulation). European Union, 2016"},{"key":"ref14","unstructured":"Danish Ministry of Justice. Act No. 502 of 23 May 2018. Act on supplementary provisions to the regulation on the protection of natural persons with regard to the processing of personal data and the free movement of such data (the Data Protection Act). Danish Ministry of Justice, 2018"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"Drerup C, Eveslage M, Sunderk\u00f6tter C, et al. Diagnostic value of laboratory parameters for the discrimination between erysipelas and limited cellulitis. J Dtsch Dermatol Ges. 2020;18(12):1417-1424. https:\/\/doi.org\/10.1111\/ddg.14252","DOI":"10.1111\/ddg.14252"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"Bodansky DMS, Begaj I, Evison F, et al. A 16-year longitudinal cohort study of incidence and bacteriology of necrotising fasciitis in England. World J Surg. 2020;44(8):2580-2591. https:\/\/doi.org\/10.1007\/s00268-020-05559-2","DOI":"10.1007\/s00268-020-05559-2"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"Hedetoft M, Madsen MB, Madsen LB, Hyldegaard O. Incidence, comorbidity and mortality in patients with necrotising soft-tissue infections, 2005-2018: a Danish nationwide register-based cohort study. BMJ Open. 2020;10(10):e041302. https:\/\/doi.org\/10.1136\/bmjopen-2020-041302","DOI":"10.1136\/bmjopen-2020-041302"},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"Hali F, Belanouane S, Ouariti KZ, et al. Erysipelas of the leg: a cross-sectional study of risk factors for recurrence. Ann Dermatol Venereol. 2022;149(2):119-122. https:\/\/doi.org\/10.1016\/j.annder.2021.08.006","DOI":"10.1016\/j.annder.2021.08.006"},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"Henriksen DP, Nielsen SL, Laursen CB, et al. How well do discharge diagnoses identify hospitalised patients with community-acquired infections? A validation study. PLoS One. 2014;9(3):e92891. https:\/\/doi.org\/10.1371\/journal.pone.0092891","DOI":"10.1371\/journal.pone.0092891"}],"container-title":["Danish Medical Journal"],"original-title":[],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T09:28:41Z","timestamp":1761125321000},"score":1,"resource":{"primary":{"URL":"https:\/\/ugeskriftet.dk\/dmj\/A02250077"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":20,"URL":"https:\/\/doi.org\/10.61409\/a02250077","relation":{},"ISSN":["2245-1919"],"issn-type":[{"type":"electronic","value":"2245-1919"}],"subject":[],"published":{"date-parts":[[2025,8]]}}}