{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T12:13:23Z","timestamp":1788783203483,"version":"build-2803163510"},"reference-count":0,"publisher":"Danish Medical Association","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dan Med J"],"abstract":"<jats:p>INTRODUCTION. Statin-induced myopathy (SIM) is a rare but serious complication of statin therapy. Immune-mediated necrotising myopathy linked to anti-3-hydroxy-3-methylglutaryl (HMG)-CoA reductase (anti-HMGCR) antibodies requires timely recognition. This study examined the occurrence and documentation of SIM and the use of antibody testing in a regional cohort.\n\nMETHODS. This was a register-based study using data from regional registries and medical records (2020-2024). Patients with creatine kinase (CK) &gt; 10 \u00d7 the upper limit of normal while receiving statin therapy were identified, characterised and compared, with a special focus on anti-HMGCR antibody testing and documentation of statin intolerance.\n\nRESULTS. Among 1,003 patients, 32 (3.2%) were considered to have SIM. These patients had a higher median CK than other patients (7,800 versus 3,783 U\/l; p &lt; 0.001). High-intensity therapy was more frequent in SIM (72% versus 52%; p = 0.02), with a prevalence ratio of 2.34 (95% CI: 1.09-5.00). Anti-HMGCR testing was performed in 56% of SIM cases; antibody-positive patients had lower CK and higher eGFR. Documentation of statin intolerance in the electronic record CAVE field (adverse drug reaction) was present in only 59%.\n\nCONCLUSIONS. Severe SIM is uncommon (4.3 cases\/100,000 patient-years), but documentation and diagnostic testing are inconsistent. Systematic recording and broader antibody testing may improve patient safety.\n\nFUNDING. None.\n\nTRIAL REGISTRATION. Not relevant.<\/jats:p>","DOI":"10.61409\/a02260103","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T12:06:23Z","timestamp":1788782783000},"page":"1-6","source":"Crossref","is-referenced-by-count":0,"title":["Statin-induced myopathy is rare"],"prefix":"10.61409","author":[{"given":"Philip Lindblad","family":"Thorsen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Sophie","family":"Okkels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Trolle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Breining","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"40208","published-online":{"date-parts":[[2026,8]]},"container-title":["Danish Medical Journal"],"original-title":[],"deposited":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T12:06:26Z","timestamp":1788782786000},"score":1,"resource":{"primary":{"URL":"https:\/\/ugeskriftet.dk\/dmj\/A02260103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":0,"URL":"https:\/\/doi.org\/10.61409\/a02260103","relation":{},"ISSN":["2245-1919"],"issn-type":[{"value":"2245-1919","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]}}}