{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T21:47:32Z","timestamp":1777931252999,"version":"3.51.4"},"reference-count":20,"publisher":"Danish Medical Association","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dan Med J"],"abstract":"<jats:p>INTRODUCTION. Studies have shown varying patient adherence to long-term non-invasive positive airway pressure therapy (nPAP). We aimed to investigate adherence to long-term nPAP in a Danish cohort of patients with chronic respiratory insufficiency and\/or sleep-disordered breathing (SDB) due to neuromuscular disorders (NMD), obesity-hypoventilation syndrome (OHS) or other reasons.\n\nMETHODS. This cohort study included all adult patients with association to the Respiratory Center East treated with long-term nPAP: bilevel (BiPAP), automatic (APAP) and continuous (CPAP) or adaptive servo-ventilation (ASV) with a remote monitoring system in April 2022. The primary outcome was adherence, defined as a median use of nPAP \u2265 4 hrs\/day in April 2022. A preplanned extended subgroup analysis was conducted for patients with data on adherence from initiation and six months onwards.\n\nRESULTS. The primary analysis included 241 patients, of whom 90% were diagnosed with NMD (54%) or OHS (36%). The nPAP was used \u2265 4 hrs\/day by 175 patients (73%), including 22 (100%) with ASV, 129 (72%) with BiPAP and 24 (59%) with APAP\/CPAP. Treatment adherence was seen in 75% of patients with NMD, 64% with OHS and 84% with other reasons for SDB. The proportion of adherent subjects in the subgroup analysis of 55 patients was relatively stable throughout the six-month period, ranging from 67% to 75% with slight intraindividual variation.\n\nCONCLUSION. In this retrospective analysis of adults primarily with NMD and OHS, 73% used the prescribed nPAP therapy \u2265 4 hrs\/day.\n\nFUNDING. None\n\nTRIAL REGISTRATION. ClinicalTrials.gov(NCT05379309).<\/jats:p>","DOI":"10.61409\/a04240290","type":"journal-article","created":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T08:15:54Z","timestamp":1732263354000},"page":"1-10","source":"Crossref","is-referenced-by-count":1,"title":["Adherence to long-term non-invasive positive airway pressure therapy"],"prefix":"10.61409","author":[{"given":"Anne Kathrine","family":"Staehr-Rye","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tanja \u00d8stergaard","family":"Irlind","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Funderskov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mona Ring","family":"G\u00e4tke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simone Henrietta Lisa","family":"K\u00fcchen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"40208","published-online":{"date-parts":[[2024,11,1]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"Patil SP, Ayappa IA, Caples SM, et al. 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