{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T18:58:01Z","timestamp":1754161081641,"version":"3.41.2"},"reference-count":18,"publisher":"Danish Medical Association","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dan Med J"],"abstract":"<jats:p>INTRODUCTION. Knowledge of the characteristics of those who undergo major lower-extremity amputation (LEA) in Denmark is lacking. In this study, we described socioeconomic and demographic factors, comorbidity, healthcare contacts and mortality in people who underwent major LEA.\n\nMETHODS. This was a descriptive observational study. We identified first non-traumatic major LEAs (2019-2021) in the National Patient Registry and classified people by diabetes status. We matched the LEA population to people from the general population based on age, sex, calendar quarter and diabetes status and linked data on socioeconomic and demographic factors, comorbidity, healthcare contacts and mortality from national administrative registries\n\nRESULTS. The LEA population constituted 3,088 people (no diabetes: N = 1,722, 55.8%; type 1 diabetes: 153, 5.0%; type 2 diabetes: N = 1,213, 39.3%). Compared to the reference group, a higher proportion of the LEA population were single, had basic education, were in a low-income group and resided in a non-urban municipality. The LEA population had many healthcare contacts leading up to their major LEA, and a very high proportion had comorbidities, most notably cardiovascular disease (85.1%). Lastly, 30-day and one-year mortality were 15.8% and 29.3%, respectively.\n\nCONCLUSIONS. About two in five who underwent major LEA had diabetes. We found marked social inequality, higher comorbidity, higher mortality and more healthcare contacts in the LEA population than in the reference group.\n\nFUNDING. None.\n\nTRIAL REGISTRATION. Not relevant.<\/jats:p>","DOI":"10.61409\/a04240294","type":"journal-article","created":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T02:58:19Z","timestamp":1740711499000},"page":"1-8","source":"Crossref","is-referenced-by-count":0,"title":["Diabetes and vulnerabilities in people undergoing lower-extremity amputation"],"prefix":"10.61409","author":[{"given":"Martin Gillies Banke","family":"Rasmussen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara Fokdal","family":"Lehn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lise","family":"Tarnow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lau Caspar","family":"Thygesen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan Erik","family":"Henriksen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"40208","published-online":{"date-parts":[[2025,3,1]]},"reference":[{"key":"ref0","unstructured":"Diabetesforeningen. Diabetestal. Diabetesforeningen, 2023. www.diabetestal.nu\/ (16 Oct 2023)"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Carstensen B, R\u00f8nn PF, J\u00f8rgensen ME. Components of diabetes prevalence in Denmark 1996-2016 and future trends until 2030. BMJ Open Diabetes Res Care. 2020;8(1):e001064. https:\/\/doi.org\/10.1136\/bmjdrc-2019-001064","DOI":"10.1136\/bmjdrc-2019-001064"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"Nicolaisen SK, Pedersen L, Witte DR et al. HbA1c-defined prediabetes and progression to type 2 diabetes in Denmark: a population-based study based on routine clinical care laboratory data. Diabetes Res Clin Pract. 2023;203:110829. https:\/\/doi.org\/10.1016\/j.diabres.2023.110829","DOI":"10.1016\/j.diabres.2023.110829"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"Apelqvist J, Larsson J. What is the most effective way to reduce incidence of amputation in the diabetic foot? 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Copenhagen: NOMESCO, 2010. https:\/\/norden.diva-portal.org\/smash\/get\/diva2:970547\/FULLTEXT01.pdf (Dec 2024)"},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"Carstensen B, R\u00f8nn PF, J\u00f8rgensen ME. Prevalence, incidence and mortality of type 1 and type 2 diabetes in Denmark 1996-2016. BMJ Open Diabetes Res Care. 2020;8(1):e001071. https:\/\/doi.org\/10.1136\/bmjdrc-2019-001071","DOI":"10.1136\/bmjdrc-2019-001071"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"Andersen N, Hjortdal J, Schielke KC et al. The Danish Registry of Diabetic Retinopathy. Clin Epidemiol. 2016;8:613-9. https:\/\/doi.org\/10.2147\/CLEP.S99507","DOI":"10.2147\/CLEP.S99507"},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"Essien SK, Zucker-Levin A. Comorbidity and risk factors of subsequent lower extremity amputation in patients diagnosed with diabetes in Saskatchewan, Canada. 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Holb\u00e6k: Fagligt Selskab for Ortop\u00e6dkirurgisk Sygepleje, 2021"}],"container-title":["Danish Medical Journal"],"original-title":[],"deposited":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T13:54:02Z","timestamp":1753710842000},"score":1,"resource":{"primary":{"URL":"https:\/\/ugeskriftet.dk\/dmj\/A04240294"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,1]]},"references-count":18,"URL":"https:\/\/doi.org\/10.61409\/a04240294","relation":{},"ISSN":["2245-1919"],"issn-type":[{"type":"electronic","value":"2245-1919"}],"subject":[],"published":{"date-parts":[[2025,3,1]]}}}