{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T18:56:06Z","timestamp":1754160966633,"version":"3.41.2"},"reference-count":18,"publisher":"Danish Medical Association","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dan Med J"],"abstract":"<jats:p>INTRODUCTION. Percutaneous needle fasciotomy (PNF) is a non-invasive treatment option for finger flexion contractures caused by Dupuytren\u2019s disease. Variations in PNF techniques include the use of corticosteroid injection. In the presented randomised controlled trial, we compare the efficacy of PNF +\/- corticosteroid injection in terms of reducing the recurrence rate.\n\nMETHODS. This study is performed as a two-armed, randomised controlled trial with a two-year follow-up. Patients will be allocated 1:1 to either PNF with corticosteroid injection (n = 200) or PNF with saline injection (n = 200). Follow-up is conducted at 90 days, one year, and two years after treatment. A finger goniometer will be used to assess finger extension deficit. Treatment complications and adverse events will be recorded, and patient-reported outcomes will be registered utilizing hand-specific and quality-of-life questionnaires.\n\nCONCLUSIONS. This study is expected to be the first randomised controlled trial to compare PNF +\/- single corticosteroid injection in a large cohort of patients with Dupuytren\u2019s contracture. The results will contribute to evidence-based recommendations for the treatment of Dupuytren\u2019s contracture.\n\nFUNDING. The trial is funded by grants from the Graduate School of Health at Aarhus University, the Danish Rheumatism Association, the Danish Medical Association Foundation and the AP. M\u00f8ller Foundation.\n\nTRIAL REGISTRATION. The trial is registered with the CTIS (EU CT: 2022-501549-57-00) and Clinicaltrials.gov (NCT05440240).<\/jats:p>","DOI":"10.61409\/a05240324","type":"journal-article","created":{"date-parts":[[2025,1,13]],"date-time":"2025-01-13T06:31:36Z","timestamp":1736749896000},"page":"1-9","source":"Crossref","is-referenced-by-count":0,"title":["Adjuvant steroid to percutaneous needle fasciotomy for Dupuytren\u2019s contracture. An RCT study protocol"],"prefix":"10.61409","author":[{"given":"Laura Houstrup","family":"Matthiesen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon Toftgaard","family":"Skov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeppe","family":"Lange","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"40208","published-online":{"date-parts":[[2024,12,1]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"Hindocha S, McGrouther DA, Bayat A. Epidemiological evaluation of Dupuytren's disease incidence and prevalence rates in relation to etiology. Hand (N Y). 2009;4(3):256-69. https:\/\/doi.org\/10.1007\/s11552-008-9160-9","DOI":"10.1007\/s11552-008-9160-9"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Lanting R, van Den Heuvel ER, Westerink B, et al. Prevalence of Dupuytren disease in the Netherlands. Plast Reconstr Surg. 2013;132(2):394-403. https:\/\/doi.org\/10.1097\/PRS.0b013e3182958a33","DOI":"10.1097\/PRS.0b013e3182958a33"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"Shih B, Bayat A. Scientific understanding and clinical management of Dupuytren disease. Nat Rev Rheumatol. 2010;6(12):715-26. https:\/\/doi.org\/10.1038\/nrrheum.2010.180","DOI":"10.1038\/nrrheum.2010.180"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"Wilburn J, McKenna SP, Perry-Hinsley D, et al. The impact of Dupuytren disease on patient activity and quality of life. J Hand Surg Am. 2013;38(6):1209-14. https:\/\/doi.org\/10.1016\/j.jhsa.2013.03.036","DOI":"10.1016\/j.jhsa.2013.03.036"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"Dias J, Bainbridge C, Leclercq C et al. Surgical management of Dupuytren's contracture in Europe: regional analysis of a surgeon survey and patient chart review. Int J Clin Pract. 2013;67(3):271-81. https:\/\/doi.org\/10.1111\/ijcp.12106","DOI":"10.1111\/ijcp.12106"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"Hurst LC, Badalamente MA, Hentz VR, et al. Injectable collagenase clostridium histolyticum for Dupuytren's contracture. N Engl J Med. 2009;361(10):968-79. https:\/\/doi.org\/10.1056\/NEJMoa0810866","DOI":"10.1056\/NEJMoa0810866"},{"key":"ref6","unstructured":"Lermusiaux J, Debeyre N. Le traitement m\u00e9dical de la maladie de Dupuytren. L'Actualit\u00e9 Rhumatol Paris Expans Sci Publ. 1979:238-49."},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"Rahr L, S\u00f8ndergaard P, Bisgaard T, et al. Percutaneous needle fasciotomy for primary Dupuytren's contracture. J Hand Surg Eur. 2011;36(7):548-52. https:\/\/doi.org\/10.1177\/1753193411407245","DOI":"10.1177\/1753193411407245"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"Str\u00f6mberg J, S\u00f6rensen AI, Frid\u00e9n J. Percutaneous needle fasciotomy versus collagenase treatment for Dupuytren contracture: a randomized controlled trial with a two-year follow-up. J Bone Joint Surg Am. 2018;100(13):1079-86. https:\/\/doi.org\/10.2106\/JBJS.17.01128","DOI":"10.2106\/JBJS.17.01128"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"Skov ST, Bisgaard T, S\u00f8ndergaard P, et al. Injectable collagenase versus percutaneous needle fasciotomy for Dupuytren contracture in proximal interphalangeal joints: a randomized controlled trial. J Hand Surg Am. 2017;42(5):321-328.e3. https:\/\/doi.org\/10.1016\/j.jhsa.2017.03.003","DOI":"10.1016\/j.jhsa.2017.03.003"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"Therkelsen LH, Skov ST, Laursen M, et al. Percutaneous needle fasciotomy in Dupuytren contracture: a register-based, observational cohort study on complications in 3,331 treated fingers in 2,257 patients. Acta Orthop. 2020;91(3):326-30. https:\/\/doi.org\/10.1080\/17453674.2020.1726057","DOI":"10.1080\/17453674.2020.1726057"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"van Rijssen AL, Gerbrandy FSJ, Linden HT, et al. A comparison of the direct outcomes of percutaneous needle fasciotomy and limited fasciectomy for Dupuytren's disease: a 6-week follow-up study. J Hand Surg Am. 2006;31(5):717-25. https:\/\/doi.org\/10.1016\/j.jhsa.2006.02.021","DOI":"10.1016\/j.jhsa.2006.02.021"},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"Str\u00f6mberg J, Ibsen-S\u00f6rensen A, Frid\u00e9n J. Comparison of treatment outcome after collagenase and needle fasciotomy for Dupuytren contracture: a randomized, Single-blinded, clinical trial with a 1-year follow-up. J Hand Surg Am. 2016;41(9):873-80. https:\/\/doi.org\/10.1016\/j.jhsa.2016.06.014","DOI":"10.1016\/j.jhsa.2016.06.014"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"Pess GM, Pess RM, Pess RA. Results of needle aponeurotomy for Dupuytren contracture in over 1,000 fingers. J Hand Surg Am. 2012;37(4):651-6. https:\/\/doi.org\/10.1016\/j.jhsa.2012.01.029","DOI":"10.1016\/j.jhsa.2012.01.029"},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"McMillan C, Binhammer P. Steroid injection and needle aponeurotomy for Dupuytren contracture: a randomized, controlled study. J Hand Surg Am. 2012;37(7):1307-12. https:\/\/doi.org\/10.1016\/j.jhsa.2012.04.026","DOI":"10.1016\/j.jhsa.2012.04.026"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"Ketchum LD, Donahue TK. The injection of nodules of Dupuytren's disease with triamcinolone acetonide. J Hand Surg Am. 2000;25(6):1157-62. https:\/\/doi.org\/10.1053\/jhsu.2000.18493","DOI":"10.1053\/jhsu.2000.18493"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"McMillan C, Binhammer P. Steroid injection and needle aponeurotomy for Dupuytren disease: long-term follow-up of a randomized controlled trial. J Hand Surg Am. 2014;39(10):1942-7. https:\/\/doi.org\/10.1016\/j.jhsa.2014.07.018","DOI":"10.1016\/j.jhsa.2014.07.018"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"Scherman P, Jenmalm P, Dahlin LB. Three-year recurrence of Dupuytren's contracture after needle fasciotomy and collagenase injection: a two-centre randomized controlled trial. J Hand Surg Eur. 2018;43(8):836-40. https:\/\/doi.org\/10.1177\/1753193418786947","DOI":"10.1177\/1753193418786947"}],"container-title":["Danish Medical Journal"],"original-title":[],"deposited":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T08:37:11Z","timestamp":1753691831000},"score":1,"resource":{"primary":{"URL":"https:\/\/ugeskriftet.dk\/dmj\/A05240324"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,1]]},"references-count":18,"URL":"https:\/\/doi.org\/10.61409\/a05240324","relation":{},"ISSN":["2245-1919"],"issn-type":[{"type":"electronic","value":"2245-1919"}],"subject":[],"published":{"date-parts":[[2024,12,1]]}}}