{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T12:24:31Z","timestamp":1763641471146,"version":"3.45.0"},"reference-count":22,"publisher":"Danish Medical Association","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dan Med J"],"abstract":"<jats:p>INTRODUCTION. We determined the semiology, causes, risk factors and outcomes of patients with acute nutritional neuropathies requiring hospitalisation in high-income countries.\n\nMETHODS. We searched PubMed, Cochrane Library and Embase for non-alcoholic malnutrition neuropathy cases published since 1990.\n\nRESULTS. Thirty-six studies were identified, including 83 patients (mean age 39.8 years; 70% women) with deficient levels of thiamine (54%), pyridoxine (16%), copper (11%) or folate (7%). Common clinical signs were lower extremity weakness (100%), hypesthesia (63%), hypo-\/areflexia (54%) and cranial nerve deficits (27%). Thirty-two (39%) patients also had Wernicke\u2019s encephalopathy. The mean time from symptom onset to hospitalisation was 4.2 weeks (range: 1-12). Ten (12.1%) patients required intensive care. Risk factors were weight loss (60%), vomiting (51%) and diarrhoea (11%). Aetiologies included bariatric surgery (n = 60, 72%), psychiatric disorders (n = 15, 18%) and hyperemesis gravidarum (n = 4, 5%). Electrophysiology showed axonal polyneuropathy in 60 (72.3%) patients, typically with sensorimotor involvement (n = 42). Besides nutritional supplements, 19 (23%) patients also received IVIG, plasmapheresis or steroids. Forty-nine patients had a one-year follow-up, with a good outcome (modified Rankin Scale Score \u2264 2) in 25 (51%).\n\nCONCLUSIONS. Nutritional neuropathies may mimic axonal Guillain-Barr\u00e9 syndrome. Early recognition is crucial to avoid lasting deficits and unnecessary therapy like IVIG or plasmapheresis.<\/jats:p>","DOI":"10.61409\/a05250359","type":"journal-article","created":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T09:05:11Z","timestamp":1761901511000},"page":"1-12","source":"Crossref","is-referenced-by-count":0,"title":["Acute non-alcoholic nutritional neuropathies in high-income countries \u2013 a systematic review"],"prefix":"10.61409","author":[{"given":"Karen Irgens Tanderup","family":"Hansen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth Waldemar","family":"Gr\u00f8nlund","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Kondziella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"40208","published-online":{"date-parts":[[2025,10]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"Sejvar JJ, Baughman AL, Wise M, Morgan OW. 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