{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T00:48:43Z","timestamp":1755218923273,"version":"3.43.0"},"reference-count":17,"publisher":"Danish Medical Association","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dan Med J"],"abstract":"<jats:p>INTRODUCTION. Acute Charcot foot is a rare but serious complication of diabetes mellitus. With improved diabetes treatment, the annual incidence of acute Charcot foot may have decreased. This study aimed to investigate the annual incidence and incidence rate of acute Charcot foot in patients with an ICD diagnosis code of diabetes in Denmark from 2000 to 2021. Furthermore, the analyses included differences between the five Danish regions. Finally, the impact of the COVID-19 pandemic and the nurses\u2019 strike in the summer of 2021 in Denmark was also examined.\n\nMETHODS. This was a register-based study conducted in Denmark from 2000 to 2021. Nation-wide and regional, annual incidence and incidence rates of acute Charcot foot were calculated. Kendall\u2019s tau was used to test changes in incidence rates.\n\nRESULTS. A significant increase was found in the annual incidence of acute Charcot foot with a correlation of 0.6 (p &lt; 0.0005) together with a decline in the annual incidence rate of acute Charcot foot (correlation of \u22120.6 with p = 0.0005). No differences were observed between theDanish regions. No change in acute Charcot foot incidence rate among diabetes patients was found during 2018-2021 (correlation of 0.3; p = 0.5).\n\nCONCLUSION. The annual incidence increased, whereas the annual incidence rate of acute Charcot foot in patients with an ICD diagnosis code of diabetes in Denmark declined during 2000-2021, with no significant regional differences or change during the COVID-19 and nurses\u2019 strike.\n\nFUNDING. None.\n\nTRIAL REGISTRATION. Not relevant.<\/jats:p>","DOI":"10.61409\/a08240556","type":"journal-article","created":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T05:20:42Z","timestamp":1742966442000},"page":"1-9","source":"Crossref","is-referenced-by-count":0,"title":["Incidence of acute Charcot foot in patients with diabetes"],"prefix":"10.61409","author":[{"given":"Osman Heider","family":"Ahmed","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matilde","family":"Winther-Jensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ole Lander","family":"Svendsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"40208","published-online":{"date-parts":[[2025,4,1]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"Jansen RB, J\u00f8rgensen B, Holstein PE et al. Mortality and complications after treatment of acute diabetic Charcot foot. J Diabetes Complications. 2018;32(12):1141-7. https:\/\/doi.org\/10.1016\/j.jdiacomp.2018.09.013","DOI":"10.1016\/j.jdiacomp.2018.09.013"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Jansen RB, Svendsen OL. A review of bone metabolism and developments in medical treatment of the diabetic Charcot foot. J Diabetes Complications. 2018;32(7):708-12. https:\/\/doi.org\/10.1016\/j.jdiacomp.2018.04.010","DOI":"10.1016\/j.jdiacomp.2018.04.010"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"Rabe OC, Winther-Jensen M, Allin KH, et al. Fractures and osteoporosis in patients with diabetes with Charcot foot. Diabetes Care. 2021;44(9):2033-8. https:\/\/doi.org\/10.2337\/dc21-0369","DOI":"10.2337\/dc21-0369"},{"key":"ref3","unstructured":"National Institute of Health U.S. National Library of Medicine (2023). Efficacy of treatment with DENOsumab of an acute CHARCOT foot in patients with diabetes. A multicenter, double-blind, randomized, placebo-controlled trial. NIH, National Library of Medicine, 2023. https:\/\/clinicaltrials.gov\/ct2\/show\/NCT04547348?cond=denocharcot&draw=2&rank=1 (11 Sep 2024)"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"Svendsen OL, Rabe OC, Winther-Jensen M, Allin KH. How common is the rare Charcot foot in patients with diabetes? Diabetes Care. 2021;44(4):e62-e63. https:\/\/doi.org\/10.2337\/dc20-2590","DOI":"10.2337\/dc20-2590"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"Mizrak IH, Hansen TW, Rossing P et al. Declining incidence rates of distal symmetric polyneuropathy in people with type 1 and type 2 diabetes in Denmark with indications of distinct patterns in type 1 diabetes. Diabetes Care. 2023;46(1):1997-2003. https:\/\/doi.org\/10.2337\/dc23-0312","DOI":"10.2337\/dc23-0312"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"Andersen JS, Olivarius NdF, Krasnik A. The Danish National Health Service Register. Scand J Public Health. 2011;39(suppl):34-7. https:\/\/doi.org\/10.1177\/1403494810394718","DOI":"10.1177\/1403494810394718"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"Pedersen CB. The Danish civil registration system. Scand J Public Health. 2011;39(7 suppl.):22-5. https:\/\/doi.org\/10.1177\/1403494810387965","DOI":"10.1177\/1403494810387965"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"Thygesen LC, Daasnes C, Thaulow I, Br\u00f8nnum-Hansen H. Introduction to Danish (nationwide) registers on health and social issues: structure, access, legislation, and archiving. Scand J Public Health. 2011;39(suppl.):12-6. https:\/\/doi.org\/10.1177\/1403494811399956","DOI":"10.1177\/1403494811399956"},{"key":"ref9","unstructured":"Sundhedsdatastyrelsen. SKS-browser, vers 4.06. Sundhedsdatastyrelsen, 2023. https:\/\/medinfo.dk\/sks\/brows.php (11 Sep 2024)"},{"key":"ref10","unstructured":"R Core Team. R: A language and environment for statistical computing. Vienna, Austria: R Foundation for Statistical Computing, 2022. https:\/\/www.R-project.org\/ (11 Sep 2024)"},{"key":"ref11","unstructured":"International Diabetes Federation. IDF diabetes atlas. 10th ed., 2021. https:\/\/diabetesatlas.org (11 Sep 2024)"},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"Ali MK, Pearson-Stuttard J, Selvin E, Gregg EW. Interpreting global trends in type 2 diabetes complications and mortality. Diabetologia. 2022;65(1):3-13. https:\/\/doi.org\/10.1007\/s00125-021-05585-2","DOI":"10.1007\/s00125-021-05585-2"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"Gregg EW, Li Y, Wang J et al. Changes in diabetes-related complications in the United States, 1990-2010. N Engl J Med. 2014;370(16):1514-23. https:\/\/doi.org\/10.1056\/NEJMoa1310799","DOI":"10.1056\/NEJMoa1310799"},{"key":"ref14","unstructured":"Svendsen OL, Kirketerp-M\u00f8ller K, Olsen JB, Palm H. Amputations in Denmark in patients with diabetes. Ugeskr L\u00e6ger. 2023:185:V03230194"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"Vas PRJ, Edmonds M, Kavarthapu V et al. The diabetic foot attack: \"tis too late to retreat!\" Int J Low Extrem Wounds. 2018;17(1):7-13. https:\/\/doi.org\/10.1177\/1534734618755582","DOI":"10.1177\/1534734618755582"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"Carstensen B, R\u00f8nn PF, J\u00f8rgensen ME. Prevalence, incidence and mortality of type 1 and type 2 diabetes in Denmark 1996-2016. BJM Open Diabetes Res Care. 2020;8(1):e001071. https:\/\/doi.org\/10.1136\/bmjdrc-2019-001071","DOI":"10.1136\/bmjdrc-2019-001071"}],"container-title":["Danish Medical Journal"],"original-title":[],"deposited":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T13:23:03Z","timestamp":1754486583000},"score":1,"resource":{"primary":{"URL":"https:\/\/ugeskriftet.dk\/dmj\/A08240556"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,1]]},"references-count":17,"URL":"https:\/\/doi.org\/10.61409\/a08240556","relation":{},"ISSN":["2245-1919"],"issn-type":[{"type":"electronic","value":"2245-1919"}],"subject":[],"published":{"date-parts":[[2025,4,1]]}}}