{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T00:48:48Z","timestamp":1755218928724,"version":"3.43.0"},"reference-count":19,"publisher":"Danish Medical Association","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dan Med J"],"abstract":"<jats:p>INTRODUCTION. Video-assisted thoracoscopic surgery (VATS) lobectomy is increasingly replacing open thoracotomy as the standard surgical treatment for early-stage non-small cell lung cancer owing to its greater efficacy, as demonstrated in RCTs. This study aimed to examine the effectiveness and evolution of lung cancer treatment by VATS lobectomy in a single centre.\n\nMETHODS. This retrospective single-centre cohort study at the Department of Cardiothoracic and Vascular Surgery, Aarhus University Hospital, Denmark, examined operative reports for all VATS lobectomies performed in-house from 3 March 2008 to 6 July 2023, as well as medical records at one-year follow-up for 10% of the patients.\n\nRESULTS. VATS lobectomies were identified (N = 1,705). A steady annual increase in performed procedures and the number of performing surgeons was observed, and more frail patients underwent the procedure. Operation time, mean chest tube drainage time, length of hospitalisation and rate of annual conversions declined along with the amount and severity of post-operative complications, cancer recurrence and mortality at the one-year follow-up.\n\nCONCLUSIONS. Treatment effectiveness, measured by peri- and post-operative outcomes, aligned with the efficiency presented in RCTs, with significant benefits of VATS compared to traditional anterolateral thoracotomy. Furthermore, treatment effectiveness evolved during the study period, and the introduction and training of new surgeons improved, enhancing the quality and availability of VATS throughout the period.\n\nFUNDING. None.\n\nTRIAL REGISTRATION. Not relevant.<\/jats:p>","DOI":"10.61409\/a09240649","type":"journal-article","created":{"date-parts":[[2025,3,26]],"date-time":"2025-03-26T05:20:42Z","timestamp":1742966442000},"page":"1-10","source":"Crossref","is-referenced-by-count":0,"title":["The experience of video-assisted thoracoscopic lobectomies"],"prefix":"10.61409","author":[{"given":"Kasper","family":"Steen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"40208","published-online":{"date-parts":[[2025,4,1]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"Bendixen M, J\u00f8rgensen OD, Kronborg C et al. Postoperative pain and quality of life after lobectomy via video-assisted thoracoscopic surgery or anterolateral thoracotomy for early stage lung cancer: a randomised controlled trial. Lancet Oncol. 2016;17(6):836-44. https:\/\/doi.org\/10.1016\/S1470-2045(16)00173-X","DOI":"10.1016\/S1470-2045(16)00173-X"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Lim E, Harris RA, McKeon HE et al. Impact of video-assisted thoracoscopic lobectomy versus open lobectomy for lung cancer on recovery assessed using self-reported physical function: VIOLET RCT. Health Technol Assess. 2022;26(48):1-162. https:\/\/doi.org\/10.3310\/THBQ1793","DOI":"10.3310\/THBQ1793"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"Sihoe ADL. Video-assisted thoracoscopic surgery as the gold standard for lung cancer surgery. Respirology. 2020;25(suppl 2):49-60. https:\/\/doi.org\/10.1111\/resp.13920","DOI":"10.1111\/resp.13920"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"Jakobsen E, Rasmussen TR. The Danish Lung Cancer Registry. Clin Epidemiol. 2016;8:537-41. https:\/\/doi.org\/10.2147\/CLEP.S99458","DOI":"10.2147\/CLEP.S99458"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"Dansk Lunge Cancer Gruppe. Lungecancer - Kirurgisk behandling. Version 3.0. Dansk Lunge Cancer Gruppe, 2023. www.dmcg.dk\/siteassets\/kliniske-retningslinjer---skabeloner-og-vejledninger\/kliniske-retningslinjer-opdelt-pa-dmcg\/dlcg\/dlcg_kir_bh_v.3.0_admgodk_14.12.2023.pdf (15 Mar 2024).","DOI":"10.1159\/000535378"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"Guerrera F, Olland A, Ruffini E et al. VATS lobectomy vs. open lobectomy for early-stage lung cancer: an endless question-are we close to a definite answer? J Thorac Dis. 2019;11(12):5616-8. https:\/\/doi.org\/10.21037\/jtd.2019.12.19","DOI":"10.21037\/jtd.2019.12.19"},{"key":"ref6","unstructured":"Danish Health Authority. Pakkeforl\u00f8b for lungekr\u00e6ft. Version 2.1. Danish Health Authority, 2018."},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"Charlson ME, Pompei P, Ales KL et al. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40(5):373-83. https:\/\/doi.org\/10.1016\/0021-9681(87)90171-8","DOI":"10.1016\/0021-9681(87)90171-8"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"Dindo D, Demartines N, Clavien PA. Classification of surgical complications: a new proposal with evaluation in a cohort of 6336 patients and results of a survey. Ann Surg. 2004;240(2):205-13. https:\/\/doi.org\/10.1097\/01.sla.0000133083.54934.ae","DOI":"10.1097\/01.sla.0000133083.54934.ae"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"Slankamenac K, Graf R, Barkun J et al. The comprehensive complication index: a novel continuous scale to measure surgical morbidity. Ann Surg. 2013;258(1):1-7. https:\/\/doi.org\/10.1097\/SLA.0b013e318296c732","DOI":"10.1097\/SLA.0b013e318296c732"},{"key":"ref10","unstructured":"Hansen HJ, Petersen RH. Video-assisted thoracoscopic lobectomy using a standardized three-port anterior approach - The Copenhagen experience. Ann Cardiothorac Surg. 2012;1(1):70-6. https:\/\/doi.org\/10.3978\/j.issn.2225-319X.2012.04.15"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"Petrella F, Spaggiari L. Prolonged air leak after pulmonary lobectomy. J Thoraci Dis. 2019;11(suppl 15):S1976-S1978. https:\/\/doi.org\/10.21037\/jtd.2019.07.49","DOI":"10.21037\/jtd.2019.07.49"},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"de Angelis P, Tan KS, Chudgar NP et al. Operative time is associated with postoperative complications after pulmonary lobectomy. Ann Surg. 2023;278(6):e1259-e1266. https:\/\/doi.org\/10.1097\/SLA.0000000000005696","DOI":"10.1097\/SLA.0000000000005696"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"Konge L, Petersen RH, Hansen HJ et al. No extensive experience in open procedures is needed to learn lobectomy by video-assisted thoracic surgery. Interact Cardiovasc Thorac Surg. 2012;15(6):961-5. https:\/\/doi.org\/10.1093\/icvts\/ivs405","DOI":"10.1093\/icvts\/ivs405"},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"Laursen L\u00d8, Petersen RH, Hansen HJ et al. Video-assisted thoracoscopic surgery lobectomy for lung cancer is associated with a lower 30-day morbidity compared with lobectomy by thoracotomy. Eur J Cardiothorac Surg. 2016;49(3):870-5. https:\/\/doi.org\/10.1093\/ejcts\/ezv205","DOI":"10.1093\/ejcts\/ezv205"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"\u00dc\u00e7vet A, Yazgan S, Samanc\u0131lar \u00d6 et al. Video-assisted thoracoscopic lobectomy and bilobectomy versus open thoracotomy for non-small cell lung cancer: mortality and survival. Turk Gogus Kalp Damar Cerrahisi Derg. 2022;30(1):66-74. https:\/\/doi.org\/10.5606\/tgkdc.dergisi.2022.20912","DOI":"10.5606\/tgkdc.dergisi.2022.20912"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"Zini J, Dayan G, T\u00eatu M et al. Intersurgeon variations in postoperative length of stay after video-assisted thoracoscopic surgery lobectomy. JTCVS Open. 2024;18:253-60. https:\/\/doi.org\/10.1016\/j.xjon.2024.01.003","DOI":"10.1016\/j.xjon.2024.01.003"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"Swanson SJ, Miller DL, McKenna RJ et al. Comparing robot-assisted thoracic surgical lobectomy with conventional video-assisted thoracic surgical lobectomy and wedge resection: Results from a multihospital database (Premier). J Thorac Cardiovasc Surg. 2014;147(3):929-37. https:\/\/doi.org\/10.1016\/j.jtcvs.2013.09.046","DOI":"10.1016\/j.jtcvs.2013.09.046"},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"Perna V, Carvajal AF, Torrecilla JA et al. Uniportal video-assisted thoracoscopic lobectomy versus other video-assisted thoracoscopic lobectomy techniques: a randomized study. Eur J Cardiothorac Surg. 2016;50(3):411-5. https:\/\/doi.org\/10.1093\/ejcts\/ezw161","DOI":"10.1093\/ejcts\/ezw161"}],"container-title":["Danish Medical Journal"],"original-title":[],"deposited":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T13:17:53Z","timestamp":1754486273000},"score":1,"resource":{"primary":{"URL":"https:\/\/ugeskriftet.dk\/dmj\/A09240649"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,1]]},"references-count":19,"URL":"https:\/\/doi.org\/10.61409\/a09240649","relation":{},"ISSN":["2245-1919"],"issn-type":[{"type":"electronic","value":"2245-1919"}],"subject":[],"published":{"date-parts":[[2025,4,1]]}}}