{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T09:43:38Z","timestamp":1792575818081,"version":"4.5.0"},"reference-count":0,"publisher":"Danish Medical Association","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dan Med J"],"abstract":"<jats:p>INTRODUCTION. The aim of this study was to evaluate the diagnostic performance of fine-needle aspiration (FNA) cytology and further evaluate the risk of malignancy (ROM) in patients with salivary gland neoplasms in a five-year period in Region Zealand, Denmark.\n\nMETHODS. Retrospectively, we identified all patients with an FNA from a salivary gland neoplasm who underwent surgery from 1 January 2020 through 31 December 2024. Descriptive statistics were performed, and sensitivity, specificity, positive and negative predictive values and ROM were estimated.\n\nRESULTS. We identified 435 patients who had a preoperative FNA and underwent surgical excision within the study period. The cohort had a small female preponderance, a mean age of 59.2 years and involvement of the parotid gland in 84.6% of cases. An assessment of the diagnostic efficacy of the FNA between benign and malignant cases reported a sensitivity of 50.0%, a specificity of 97.9%, a positive predictive value of 78.4%, a negative predictive value of 92.7% and an accuracy of 92.0%. The risk of malignancy was low in benign FNAs (0-0.6%) and high in FNAs with malignancy or suspicion hereof (75.0-100%).\n\nCONCLUSIONS. With an accuracy of 91.5% in distinguishing benign from malignant neoplasms, FNA plays a crucial role in both diagnosis and patient counselling. The inherent uncertainty must be considered when recommending and planning surgical interventions or follow-up, especially in unresolved cases.\n\nFUNDING. None.\n\nTRIAL REGISTRATION. Not relevant.<\/jats:p>","DOI":"10.61409\/a11250910","type":"journal-article","created":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T09:11:02Z","timestamp":1792573862000},"page":"1-8","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic performance of fine-needle aspiration in salivary gland tumours"],"prefix":"10.61409","author":[{"given":"Emilie S\u00f8by","family":"Kristensen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie R\u00f8sland","family":"Rosen\u00f8rn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasper","family":"Wennervaldt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gitte Bj\u00f8rn","family":"Hvilsom","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"40208","published-online":{"date-parts":[[2026,9]]},"container-title":["Danish Medical Journal"],"original-title":[],"deposited":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T09:11:03Z","timestamp":1792573863000},"score":1,"resource":{"primary":{"URL":"https:\/\/ugeskriftet.dk\/dmj\/A11250910"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":0,"URL":"https:\/\/doi.org\/10.61409\/a11250910","relation":{},"ISSN":["2245-1919"],"issn-type":[{"value":"2245-1919","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9]]}}}