{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T12:13:45Z","timestamp":1788783225078,"version":"build-2803163510"},"reference-count":0,"publisher":"Danish Medical Association","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dan Med J"],"abstract":"<jats:p>INTRODUCTION. Calcinosis cutis (CC), the deposit of insoluble calcium salts in the skin and subcutaneous tissues, is a rare condition that occurs in autoimmune connective tissue diseases, including systemic sclerosis (SSc), dermatomyositis and in non-connective tissue diseases (non-CTD), particularly in patients with calciphylaxis and nephropathy, and in chronic ulcers. CC causes significant morbidity and impacts quality of life. This study evaluated CC management strategies of patients in a clinical setting.\n\nMETHODS. A retrospective descriptive study was conducted at a university dermatology department in Denmark. We analysed all patients diagnosed with CC during 2019-2024 regarding CC distribution, treatment and follow-up, with data extracted from medical records.\n\nRESULTS. CC was diagnosed in 49 patients and was most prevalent in SSc. Lesions were located on fingers, elbows and other joints \u2013 often in areas prone to trauma. In non-CTD, most patients were diagnosed with nephropathy (50%) and chronic ulcers (70%). Sodium thiosulfate (STS) was the most frequently used treatment (87.8%). STS showed a positive effect in 30% of patients, 20% experienced no improvement and 2% experienced an adverse effect, but 48% had missing data. Surgical excision was performed in 13.9% and CO2 laser in 8.3%.\n\nCONCLUSIONS. CC management remains challenging. In non-CTD cases, CC is associated with nephropathy and chronic ulcers. SSc patients with CC present with multiple lesions, primarily on trauma-prone sites. STS shows promising effects on CC burden and pain, but more robust treatment-efficacy studies are warranted.\n\nFUNDING. None.\n\nTRIAL REGISTRATION. Not relevant.<\/jats:p>","DOI":"10.61409\/a11250920","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T12:06:23Z","timestamp":1788782783000},"page":"1-9","source":"Crossref","is-referenced-by-count":0,"title":["Clinical management of calcinosis cutis"],"prefix":"10.61409","author":[{"given":"Tuka","family":"Tabour","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Braae","family":"Olesen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luna Toppenberg","family":"Lazar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mette","family":"Mogensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"40208","published-online":{"date-parts":[[2026,8]]},"container-title":["Danish Medical Journal"],"original-title":[],"deposited":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T12:06:25Z","timestamp":1788782785000},"score":1,"resource":{"primary":{"URL":"https:\/\/ugeskriftet.dk\/dmj\/A11250920"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":0,"URL":"https:\/\/doi.org\/10.61409\/a11250920","relation":{},"ISSN":["2245-1919"],"issn-type":[{"value":"2245-1919","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8]]}}}