{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,17]],"date-time":"2025-05-17T04:06:37Z","timestamp":1747454797974,"version":"3.40.5"},"reference-count":5,"publisher":"Danish Medical Association","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ugeskr L\u00e6ger"],"abstract":"<jats:p>Statin-induced immune-mediated necrotising myopathy (IMNM) is a rare complication associated with statin use. IMNM is classified as one of the inflammatory myopathies characterised by myalgia and elevated serum creatine kinase (CK) levels. In this case report, we present a 58-year-old woman who developed IMNM secondary to atorvastatin use. The patient presented with proximal myopathy and increased CK levels. Laboratory analysis revealed the presence of anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) autoantibodies, and a muscle biopsy confirmed the presence of myofibre necrosis.<\/jats:p>","DOI":"10.61409\/v01240030","type":"journal-article","created":{"date-parts":[[2024,11,11]],"date-time":"2024-11-11T08:27:02Z","timestamp":1731313622000},"page":"1-5","source":"Crossref","is-referenced-by-count":0,"title":["Immune-mediated necrotising myopathy after several years of treatment with atorvastatin"],"prefix":"10.61409","author":[{"given":"Nerma","family":"Todorovac","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne Bruun","family":"Kr\u00f8ig\u00e5rd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice Ashouri","family":"Christiansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ghassan","family":"Jadou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"40208","published-online":{"date-parts":[[2024,10,28]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"Mammen AL. Statin-associated autoimmune myopathy. N Engl J Med. 2016;374(7):664-9. https:\/\/doi.org\/10.1056\/NEJMra1515161","DOI":"10.1056\/NEJMra1515161"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Mohassel P, Mammen AL. Anti-HMGCR myopathy. J Neuromuscul Dis. 2018;5(1):11-20. https:\/\/doi.org\/10.3233\/JND-170282","DOI":"10.3233\/JND-170282"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"Khan F, Brady S, Kuttikat A. Challenges in the diagnosis and management of immune-mediated necrotising myopathy (IMNM) in a patient on long-term statins. Rheumatol Int. 2023;43(2):383-390. https:\/\/doi.org\/10.1007\/s00296-022-05230-0","DOI":"10.1007\/s00296-022-05230-0"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"Abusharar SP, Moku P, Banks S et al. Immune mediated necrotizing myopathy: a rare complication of statin therapy. Clin Pract. 2020;10(2):1248. https:\/\/doi.org\/10.4081\/cp.2020.1248","DOI":"10.4081\/cp.2020.1248"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"Tiniakou E, Rivera E, Mammen AL, Christopher-Stine L. Use of proprotein convertase subtilisin\/kexin type 9 inhibitors in statin-associated immune-mediated necrotizing myopathy: a case series. Arthritis Rheumatol. 2019;71(10):1723-1726. https:\/\/doi.org\/10.1002\/art.40919","DOI":"10.1002\/art.40919"}],"container-title":["Ugeskrift for L\u00e6ger"],"original-title":[],"deposited":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T11:40:26Z","timestamp":1747395626000},"score":1,"resource":{"primary":{"URL":"https:\/\/ugeskriftet.dk\/videnskab\/V01240030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,28]]},"references-count":5,"URL":"https:\/\/doi.org\/10.61409\/v01240030","relation":{},"ISSN":["0041-5782","1603-6824"],"issn-type":[{"type":"print","value":"0041-5782"},{"type":"electronic","value":"1603-6824"}],"subject":[],"published":{"date-parts":[[2024,10,28]]}}}