{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T23:26:58Z","timestamp":1761175618857,"version":"build-2065373602"},"reference-count":5,"publisher":"Danish Medical Association","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ugeskr L\u00e6ger"],"abstract":"<jats:p>Multiple myeloma (MM) is a rare disease with approximately 400 new cases per year in Denmark. Involvement of the central nervous system (CNS) is only seen in around 1% of all MM cases (MM-CNS). Knowledge about MM-CNS is therefore extremely limited and diagnosing the condition is often challenging, due to heterogeneous presentations which can be confounded by neurological symptoms caused by the typical features of MM or common treatment side effects. This is a case report of a 68-year-old Danish male patient with MM-CNS and focus on awareness of this rare condition.<\/jats:p>","DOI":"10.61409\/v01250018","type":"journal-article","created":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T11:58:05Z","timestamp":1755518285000},"page":"1-3","source":"Crossref","is-referenced-by-count":0,"title":["Multiple myeloma with CNS involvement"],"prefix":"10.61409","author":[{"given":"Ruth","family":"Salim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anke","family":"Lundstr\u00f8m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emil Hjort","family":"Christensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trung Hieu","family":"Do","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"40208","published-online":{"date-parts":[[2025,8,18]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"Moreau P, San Miguel J, Ludwig H, et al. Multiple myeloma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2013;24(suppl 6):vi133-vi137. https:\/\/doi.org\/10.1093\/annonc\/mdt297","DOI":"10.1093\/annonc\/mdt297"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Egan PA, Elder PT, Deighan WI, et al. Multiple myeloma with central nervous system relapse. Haematologica. 2020;105(7):1780-1790. https:\/\/doi.org\/10.3324\/haematol.2020.248518","DOI":"10.3324\/haematol.2020.248518"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"Varga G, Mikala G, Gopcsa L, et al. Multiple myeloma of the central nervous system: 13 cases and review of the literature. J Oncol. 2018;2018:3970169. https:\/\/doi.org\/10.1155\/2018\/3970169","DOI":"10.1155\/2018\/3970169"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"Manzar GS, Dudzinski SO, Yoder AK, et al. Outcome of patients with central nervous system multiple myeloma (CNS-MM) treated with CNS-directed radiation therapy. Clin Lymphoma Myeloma Leuk. 2025;25(4):271-284. https:\/\/doi.org\/10.1016\/j.clml.2024.11.010","DOI":"10.1016\/j.clml.2024.11.010"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"Gaballa MR, Puglianini OC, Cohen A, et al. BCMA-directed CAR T-cell therapy in patients with multiple myeloma and CNS involvement. Blood Adv. 2025;9(5):1171-1180. https:\/\/doi.org\/10.1182\/bloodadvances.2024014345","DOI":"10.1182\/bloodadvances.2024014345"}],"container-title":["Ugeskrift for L\u00e6ger"],"original-title":[],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T08:50:16Z","timestamp":1761123016000},"score":1,"resource":{"primary":{"URL":"https:\/\/ugeskriftet.dk\/videnskab\/V01250018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,18]]},"references-count":5,"URL":"https:\/\/doi.org\/10.61409\/v01250018","relation":{},"ISSN":["0041-5782","1603-6824"],"issn-type":[{"type":"print","value":"0041-5782"},{"type":"electronic","value":"1603-6824"}],"subject":[],"published":{"date-parts":[[2025,8,18]]}}}