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J Pharmacol Exp Ther. 1976;199(2):464-8","journal-title":"J Pharmacol Exp Ther"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"Murphy MR, Hug CC, McClain DA. Dose-independent pharmacokinetics of fentanyl. Anesthesiology. 1983;59(6):537-40. https:\/\/doi.org\/10.1097\/00000542-198312000-00009","DOI":"10.1097\/00000542-198312000-00009"},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"Dolinak D. Opioid toxicity. Acad Forensic Pathol. 2017;7(1):19-35. https:\/\/doi.org\/10.23907\/2017.003","DOI":"10.23907\/2017.003"},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"Dahan A, Yassen A, Bijl H et al. Comparison of the respiratory effects of intravenous buprenorphine and fentanyl in humans and rats. Br J Anaesth. 2005;94(6):825-34. https:\/\/doi.org\/10.1093\/bja\/aei145","DOI":"10.1093\/bja\/aei145"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"Doshi R, Majmundar M, Kansara T et al. Frequency of cardiovascular events and in-hospital mortality with opioid overdose hospitalizations. Am J Cardiol. 2019;124(10):1528-1533. https:\/\/doi.org\/10.1016\/j.amjcard.2019.07.068","DOI":"10.1016\/j.amjcard.2019.07.068"},{"key":"ref21","unstructured":"Stolbach A, Hoffmann RS. UpToDate: Acute opioid intoxication in adults. https:\/\/www.uptodate.com\/contents\/acute-opioid-intoxication-in-adults?search=fentanyl%20overdose&source=search_result&selectedTitle=1~150&usage_type=default&display_rank=1#H2 (16. dec 2024)"},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"Tschirhart JN, Zhang S. Fentanyl-induced block of hERG channels is exacerbated by hypoxia, hypokalemia, alkalosis, and the presence of hERG1b. Mol Pharmacol. 2020;98(4):508-517. https:\/\/doi.org\/10.1124\/mol.119.119271","DOI":"10.1124\/mol.119.119271"},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"Grimsrud KN, Ivanova X, Sherwin CM et al. 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