{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:53:21Z","timestamp":1787032401599,"version":"build-2736575974"},"reference-count":5,"publisher":"Danish Medical Association","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ugeskr L\u00e6ger"],"abstract":"<jats:p>In this case report, we describe a 49-year-old man who, after treatment with sulfamethoxazole and trimethoprim developed severe respiratory insufficiency, resulting in the need for veno-venous extracorporeal membrane oxygenation. As an infectious cause was initially suspected, he underwent extensive testing and imaging before this diagnosis was reached. After cessation of treatment with sulfamethoxazole and trimethoprim, he slowly recovered his respiratory function and was discharged after one month of mechanical ventilation.<\/jats:p>","DOI":"10.61409\/v01250045","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T12:04:42Z","timestamp":1763553882000},"page":"1-5","source":"Crossref","is-referenced-by-count":1,"title":["Sulfamethoxazole with trimethoprim as a cause of severe respiratory failure"],"prefix":"10.61409","author":[{"given":"Emilie Stokholm","family":"B\u00e6kgaard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederik","family":"Schwartz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis B.","family":"Holmgaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Horwitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"Buck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"40208","published-online":{"date-parts":[[2025,11,3]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"Ahmadi F, Chalabianloo N, McArthur E, et al. Severe Acute Respiratory Failure Associated With Trimethoprim\/Sulfamethoxazole Among Adolescent and Young Adults: An Active Comparator-Restricted Disproportionality Analysis From the FDA Adverse Event Reporting System (FAERS) Database. Ann Pharmacother 2025; 10600280251320690. https:\/\/doi.org\/10.1177\/10600280251320690","DOI":"10.1177\/10600280251320690"},{"key":"ref1","unstructured":"Aronson JK. Meyler's Side Effects of Drugs. 2016. https:\/\/www.clinicalkey.com\/#!\/browse\/book\/3-s2.0-C20091624771 (6. jan 2025)"},{"key":"ref2","unstructured":"Patrick GL. An Introduction to Medicinal Chemistry. 5th ed. Oxford University Press, 2013"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"Miller J, Khan H, Mino-Kenudson M, et al. Definition and Clinical Evaluation for Trimethoprim-Sulfamethoxazole Severe Acute Respiratory Failure. Crit Care Med 2023;51(12):e264. https:\/\/doi.org\/10.1097\/CCM.0000000000006002","DOI":"10.1097\/CCM.0000000000006002"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"Goldman JL, Miller JO, Miller N, et al. HLA-B07:02 and HLA-C07:02 are associated with trimethoprim-sulfamethoxazole respiratory failure. Pharmacogenomics J 2022; 22(2):124-9. https:\/\/doi.org\/10.1038\/s41397-022-00266-8","DOI":"10.1038\/s41397-022-00266-8"}],"container-title":["Ugeskrift for L\u00e6ger"],"original-title":[],"deposited":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T12:37:31Z","timestamp":1763642251000},"score":1,"resource":{"primary":{"URL":"https:\/\/ugeskriftet.dk\/videnskab\/V01250045"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,3]]},"references-count":5,"URL":"https:\/\/doi.org\/10.61409\/v01250045","relation":{},"ISSN":["0041-5782","1603-6824"],"issn-type":[{"value":"0041-5782","type":"print"},{"value":"1603-6824","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,3]]}}}