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In this review, we compare dosing strengths and frequencies in trials: Twice-daily doses of 160 mg of elemental iron increases the ferritin- but not the haemoglobin level significantly and is poorly tolerated compared to 60-80 mg elemental iron taken daily or every other day, in mild to moderate anemia, although evidence for severe anaemia is limited.<\/jats:p>","DOI":"10.61409\/v02240100","type":"journal-article","created":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T13:26:26Z","timestamp":1730208386000},"page":"1-7","source":"Crossref","is-referenced-by-count":0,"title":["Treatment of iron deficiency and iron deficiency anaemia in menstruating women"],"prefix":"10.61409","author":[{"given":"Tsitsi Maria Kirk","family":"Jepsen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pernille","family":"Ravn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"40208","published-online":{"date-parts":[[2024,10,7]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"Mirza FG, Abdul-Kadir R, Breymann C et al. Impact and management of iron deficiency and iron deficiency anemia in women's health. Expert Rev Hematol. 2018;11(9):727-736. https:\/\/doi.org\/10.1080\/17474086.2018.1502081","DOI":"10.1080\/17474086.2018.1502081"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Ando K, Morita S, Higashi T et al. Health-related quality of life among Japanese women with iron-deficiency anemia. Qual Life Res. 2006;15(10):1559-63. https:\/\/doi.org\/10.1007\/s11136-006-0030-z","DOI":"10.1007\/s11136-006-0030-z"},{"key":"ref2","unstructured":"Dahlerup JF, Eivindson E, Jacobsen BA et al. Udredning og behandling af uforklaret an\u00e6mi med jernmangel uden synlig bl\u00f8dning. National guideline. 2023."},{"key":"ref3","unstructured":"World Health Organization. World health statistics 2022: monitoring health for the SDGs, sustainable development goals. World Health Organization, 2022."},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"Kapoor MP, Sugita M, Kawaguchi M et al. 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Iron absorption from supplements is greater with alternate day than with consecutive day dosing in iron-deficient anemic women. Haematologica. 2020;105(5):1232-1239. https:\/\/doi.org\/10.3324\/haematol.2019.220830","DOI":"10.3324\/haematol.2019.220830"},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"Stoffel NU, Cercamondi CI, Brittenham G et al. Iron absorption from oral iron supplements given on consecutive versus alternate days and as single morning doses versus twice-daily split dosing in iron-depleted women: two open-label, randomised controlled trials. Lancet Haematol. 2017;4(11):e524-e533. https:\/\/doi.org\/10.1016\/S2352-3026(17)30182-5","DOI":"10.1016\/S2352-3026(17)30182-5"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"Oflas ND, Demircio\u011flu S, Do\u011fan NY et al. Comparison of the effects of oral iron treatment every day and every other day in female patients with iron deficiency anemia. Intern Med J. 2020;50(7):854-858. https:\/\/doi.org\/10.1111\/imj.14766","DOI":"10.1111\/imj.14766"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"Kaynar LA, G\u00f6k\u00e7en S, Can F et al. Comparison of daily oral iron replacement therapy with every other day treatment in female reproductive age patients with iron-deficiency anemia. Ann Hematol. 2022;101(7):1459-1464. https:\/\/doi.org\/10.1007\/s00277-022-04835-6","DOI":"10.1007\/s00277-022-04835-6"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"Trithiphen S, Uaprasert N. Efficacy of iron supplements given on alternate days versus consecutive days in the treatment of iron deficiency anemia in women of reproductive age: non-inferiority, randomized controlled trial. Conference proceeding. 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Mol Aspects Med. 2020;75:100865. https:\/\/doi.org\/10.1016\/j.mam.2020.100865","DOI":"10.1016\/j.mam.2020.100865"}],"container-title":["Ugeskrift for L\u00e6ger"],"original-title":[],"deposited":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T06:17:10Z","timestamp":1747376230000},"score":1,"resource":{"primary":{"URL":"https:\/\/ugeskriftet.dk\/videnskab\/V02240100"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,7]]},"references-count":26,"URL":"https:\/\/doi.org\/10.61409\/v02240100","relation":{},"ISSN":["0041-5782","1603-6824"],"issn-type":[{"type":"print","value":"0041-5782"},{"type":"electronic","value":"1603-6824"}],"subject":[],"published":{"date-parts":[[2024,10,7]]}}}