{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T00:06:33Z","timestamp":1768608393699,"version":"3.49.0"},"reference-count":4,"publisher":"Danish Medical Association","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ugeskr L\u00e6ger"],"abstract":"<jats:p>Subacute sclerosing panencephalitis (SSPE) is a rare, fatal complication of measles, manifesting years after infection due to persistent measles virus in the central nervous system. An 11-year-old Syrian boy with prior measles and measles \u2013 mumps \u2013 rubella (MMR) vaccination developed progressive encephalopathy and a vegetative state. MRI showed diffuse white matter, thalamic, and pontine changes; SSPE was confirmed post-mortem. This case emphasises the need for high MMR vaccine coverage and the importance of clinical awareness of rare infectious diseases in patients from crisis-affected countries.<\/jats:p>","DOI":"10.61409\/v03250235","type":"journal-article","created":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T11:39:11Z","timestamp":1765798751000},"page":"1-4","source":"Crossref","is-referenced-by-count":0,"title":["Subacute sclerosing panencephalitis"],"prefix":"10.61409","author":[{"given":"Anna Bryan","family":"Stensb\u00f8l","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristina Tr\u00e6holt","family":"Franck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zohra Fatima","family":"Umar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Malene Landbo","family":"B\u00f8rresen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"40208","published-online":{"date-parts":[[2025,12,15]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"Campbell H, Andrews N, Brown KE, Miller E. Review of the effect of measles vaccination on the epidemiology of SSPE. Int J Epidemiol. 2007;36(6):1334-1348. https:\/\/doi.org\/10.1093\/ije\/dym207","DOI":"10.1093\/ije\/dym207"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Yousaf I, Domanico L, Nambara T, et al. The measles virus matrix F50S mutation from a lethal case of subacute sclerosing panencephalitis promotes receptor-independent neuronal spread. J Virol. 2025;99(1):e01750-24. https:\/\/doi.org\/10.1128\/jvi.01750-24","DOI":"10.1128\/jvi.01750-24"},{"key":"ref2","unstructured":"World Health Organization. Subacute sclerosing panencephalitis and measles vaccination, 2006. https:\/\/www.who.int\/groups\/global-advisory-committee-on-vaccine-safety\/topics\/measles-vaccines#cms (13. mar 2025)"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"Wendorf KA, Winter K, Zipprich J, et al. Subacute sclerosing panencephalitis: the devastating measles complication that might be more common than previously estimated. Clin Infect Dis. 2017;65(2):226-232. https:\/\/doi.org\/10.1093\/cid\/cix302","DOI":"10.1093\/cid\/cix302"}],"container-title":["Ugeskrift for L\u00e6ger"],"original-title":[],"deposited":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T13:31:12Z","timestamp":1768570272000},"score":1,"resource":{"primary":{"URL":"https:\/\/ugeskriftet.dk\/videnskab\/V03250235"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,15]]},"references-count":4,"URL":"https:\/\/doi.org\/10.61409\/v03250235","relation":{},"ISSN":["0041-5782","1603-6824"],"issn-type":[{"value":"0041-5782","type":"print"},{"value":"1603-6824","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,15]]}}}