{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T05:54:39Z","timestamp":1787032479829,"version":"build-2736575974"},"reference-count":5,"publisher":"Danish Medical Association","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ugeskr L\u00e6ger"],"abstract":"<jats:p>Recently, semi-synthetic cannabinoids have entered the illegal market and are produced to mimic the psychoactive effects of tetrahydrocannabinol (THC). This is a case report of a 19-year-old man, who was hospitalized due to severe sedation, hypotension and tachy- and bradycardia after ingestion of the semi-synthetic cannabinoids hexahydrocannabinol (HHC) and hexahydrocannabiphorol (HHC-P) mixed in food. HHC-P, HHC and metabolites were identified in blood samples. The amount of semi-synthetic cannabinoids in illegal products can be high, which can explain the described prolonged clinical effects.<\/jats:p>","DOI":"10.61409\/v04240241","type":"journal-article","created":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T07:07:05Z","timestamp":1726124825000},"page":"1-5","source":"Crossref","is-referenced-by-count":3,"title":["Severe poisoning with semi-synthetic cannabinoids"],"prefix":"10.61409","author":[{"given":"Nanna","family":"Reiter","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristian","family":"Linnet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasja \u00d8stermark","family":"Andersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian Schou","family":"Rasmussen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie Klose","family":"Nielsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen Reenberg","family":"Eriksen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorte Fris","family":"Palmqvist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"40208","published-online":{"date-parts":[[2024,9,9]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"Alves VL, Gon\u00e7alves JL, Aguiar J et al. The synthetic cannabinoids phenomenon: from structure to toxicological properties. A review. Crit Rev Toxicol. 2020;50(5):359-382. https:\/\/doi.org\/10.1080\/10408444.2020.1762539","DOI":"10.1080\/10408444.2020.1762539"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Guyon J, Paradis C, Titier K et al. Letter to the editor: the cannabinoid consumed is not necessarily the one expected: recent experience with hexahydrocannabinol. Cannabis Cannabinoid Res. (online 16. aug 2023). https:\/\/doi.org\/10.1089\/can.2023.0154","DOI":"10.1089\/can.2023.0154"},{"key":"ref2","unstructured":"European Union Drugs Agency. Spotlight on \u2026 synthetic cannabinoids. www.emcdda.europa.eu\/spotlights\/synthetic-cannabinoids_en (maj 2024)"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"O'Mahony B, O'Malley A, Kerrigan O, McDonald C. HHC-induced psychosis: a case series of psychotic illness triggered by a widely available semisynthetic cannabinoid. Ir J Psychol Med. (online 14. feb 2024). https:\/\/doi.org\/10.1017\/ipm.2024.3","DOI":"10.1017\/ipm.2024.3"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"Ferretti ML, Gournay LR, Bingaman MG, Leen-Feldner EW. A survey study of individuals using hexahydrocannabinol cannabis products: use patterns and perceived effects. Cannabis Cannabinoid Res. (online 7. nov 2023). https:\/\/doi.org\/10.1089\/can.2023.0143","DOI":"10.1089\/can.2023.0143"}],"container-title":["Ugeskrift for L\u00e6ger"],"original-title":[],"deposited":{"date-parts":[[2025,5,15]],"date-time":"2025-05-15T06:14:09Z","timestamp":1747289649000},"score":1,"resource":{"primary":{"URL":"https:\/\/ugeskriftet.dk\/videnskab\/V04240241"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,9]]},"references-count":5,"URL":"https:\/\/doi.org\/10.61409\/v04240241","relation":{},"ISSN":["0041-5782","1603-6824"],"issn-type":[{"value":"0041-5782","type":"print"},{"value":"1603-6824","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,9]]}}}