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Prevention focuses on smoking cessation, reduced alcohol consumption, and HPV vaccination.<\/jats:p>","DOI":"10.61409\/v04250250","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T07:01:56Z","timestamp":1761116516000},"page":"1-8","source":"Crossref","is-referenced-by-count":0,"title":["Head and neck cancer"],"prefix":"10.61409","author":[{"given":"Kathrine Kronberg","family":"Jakobsen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"von Buchwald","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"40208","published-online":{"date-parts":[[2025,10,13]]},"reference":[{"unstructured":"Danish Head and Neck Cancer Group. \u00c5rsrapport 2023 for den kliniske kvalitetsdatabase DAHANCA. 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Epidemiological trends and survival of oropharyngeal cancer in a high HPV-prevalent area: a Danish population-based study from 2000 to 2020. Int J Cancer. 2024;155(12):2169-2179. https:\/\/doi.org\/10.1002\/ijc.35099","key":"ref3","DOI":"10.1002\/ijc.35099"},{"doi-asserted-by":"publisher","unstructured":"Gormley M, Creaney G, Schache A, et al. Reviewing the epidemiology of head and neck cancer: definitions, trends and risk factors. Br Dent J. 2022;233(9):780-786. https:\/\/doi.org\/10.1038\/s41415-022-5166-x","key":"ref4","DOI":"10.1038\/s41415-022-5166-x"},{"doi-asserted-by":"publisher","unstructured":"von Buchwald C, Jakobsen KK, Carlander ALF, et al. TNM 8 staging system beyond p16: double HPV\/p16 status is superior to p16 alone in predicting outcome in oropharyngeal squamous cell carcinoma. 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Oral Oncol. 2019;96:1-6. https:\/\/doi.org\/10.1016\/j.oraloncology.2019.06.035","key":"ref8","DOI":"10.1016\/j.oraloncology.2019.06.035"},{"doi-asserted-by":"publisher","unstructured":"Brierley JD, Gospodarowicz MK, Wittekindt C. Skin tumours. Classification of malignant tumours. TNM, 2017. https:\/\/doi.org\/10.1002\/9780471420194.tnmc26.pub3","key":"ref9","DOI":"10.1002\/9780471420194.tnmc26.pub3"},{"unstructured":"International Agency for Research on Cancer. WHO Classification of Tumours. Head and Neck Tumours. 5th ed. Vol. 9. International Agency for Research on Cancer, 2024. www.iarc.who.int\/news-events\/publication-of-the-who-classification-of-tumours-5th-edition-volume-9-head-and-neck-tumours\/ (aug 2025)","key":"ref10"},{"unstructured":"Danish Head and Neck Cancer Group. Dansk Selskab for Hoved- og Hals Onkologi (DSHHO), Danish Head and Neck Cancer Group (DAHANCA). Nationale retningslinjer for udredning, behandling, rehabilitering og kontrolforl\u00f8b for patienter med pharynx- og larynxcancer i Danmark. DAHANCA, 2011","key":"ref11"},{"doi-asserted-by":"publisher","unstructured":"Pfister DG, Spencer S, Adelstein D, et al. Head and neck cancers, version 2.2020, NCCN Clinical Practice Guidelines in Oncology. JNCCN. 2020;18(7):873-898. https:\/\/doi.org\/10.6004\/jnccn.2020.0031","key":"ref12","DOI":"10.6004\/jnccn.2020.0031"},{"unstructured":"Danish Head and Neck Cancer Group. DAHANCA 27. Transoral laserassisteret mikrokirurgi ved T1a glottiscancer. DAHANCA, 2012. www.dahanca.dk\/CA_Adm_Web_Page?WebPageMenu=1&CA_Web_TabNummer=0 (aug 2025)","key":"ref13"},{"unstructured":"Channir HI, Isenberg AL, Rubek N, et al. Transoral robotkirurgi til behandling af hoved-hals-kr\u00e6ft. Ugeskr L\u00e6ger 2018;180:V05180341","key":"ref14"},{"unstructured":"Danish Head and Neck Cancer Group. Kr\u00e6ft i n\u00e6se og bihuler - udredning, behandling og rehabilitering af patienter med maligne tumorer i cavum nasi, de paranasale bihuler og vestibulum nasi. DAHANCA, 2020","key":"ref15"},{"unstructured":"Dansk Selskab for Hoved- og Hals Onkologi. Behandling af planocellul\u00e6rt karcinom i mundhulen. Nationale retningslinjer. Dansk Selskab for Hoved- og Hals Onkologi, 2016","key":"ref16"},{"doi-asserted-by":"publisher","unstructured":"Christensen A, Bilde A, Therkildsen MH, et al. The prevalence of occult metastases in nonsentinel lymph nodes after step-serial sectioning and immunohistochemistry in cN0 oral squamous cell carcinoma. Laryngoscope. 2011;121(2):294-298. https:\/\/doi.org\/10.1002\/lary.21375","key":"ref17","DOI":"10.1002\/lary.21375"},{"unstructured":"Danish Head and Neck Cancer Group. Radiotherapy guidelines 2020. DAHANCA, 2021","key":"ref18"},{"unstructured":"Sundhedsstyrelsen. Opf\u00f8lgningsprogram for hoved- og halskr\u00e6ft. 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The effect of prophylactic HPV vaccines on oral and oropharyngeal HPV infection: a systematic review. Viruses. 2021;13(7):1339. https:\/\/doi.org\/10.3390\/v13071339","key":"ref27","DOI":"10.3390\/v13071339"},{"doi-asserted-by":"publisher","unstructured":"Jakobsen KK, Bendtsen SK, Pallisgaard N, et al. Liquid biopsies with circulating plasma HPV-DNA measurements - a clinically applicable surveillance tool for patients with HPV-positive oropharyngeal cancer. 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