{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T01:55:42Z","timestamp":1768614942222,"version":"3.49.0"},"reference-count":4,"publisher":"Danish Medical Association","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ugeskr L\u00e6ger"],"abstract":"<jats:p>Small doses of NSAIDs can cause acute renal failure in healthy children. We present the case of a 15-year-old girl who developed acute tubulointerstitial nephritis after three days of treatment with NSAID. The patient presented with lower back pain, sore renal beds, vomiting and loss of appetite. Tests revealed affected kidney function with elevated creatinine levels and proteinuria. Final diagnosis happened through a kidney biopsy, which revealed acute tubulointerstitial nephritis. The patient was treated with prednisolone, and the paraclinical parameters were normalized.<\/jats:p>","DOI":"10.61409\/v05250413","type":"journal-article","created":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T11:50:21Z","timestamp":1767613821000},"page":"1-5","source":"Crossref","is-referenced-by-count":0,"title":["Acute renal failure triggered by a few days of NSAID use in a 15-year-old previously healthy girl"],"prefix":"10.61409","author":[{"given":"Wafie Hussein","family":"Chahrour","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorthe Sadowa","family":"Bille","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina L\u00f8rth","family":"M\u00e5rtensson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Line Thousig","family":"Sehested","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"40208","published-online":{"date-parts":[[2025,12,22]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"Clav\u00e9 S, Rousset-Rouvi\u00e8re C, Daniel L, et al. The invisible threat of non-steroidal anti-inflammatory drugs for kidneys. Front Pediatr. 2019;7:520. https:\/\/doi.org\/10.3389\/fped.2019.00520","DOI":"10.3389\/fped.2019.00520"},{"key":"ref1","unstructured":"International Society of Nephrology. KDIGO clinical practice guideline for acute kidney injury 2012. https:\/\/kdigo.org\/wp-content\/uploads\/2016\/10\/KDIGO-2012-AKI-Guideline-English.pdf (03.09.25)"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"Akcan-Arikan A, Zappitelli M, Loftis LL, et al. Modified RIFLE criteria in critically ill children with acute kidney injury. Kidney Int. 2007;71(10):1028-1035. https:\/\/doi.org\/10.1038\/sj.ki.5002231","DOI":"10.1038\/sj.ki.5002231"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"Mart\u00ednez L\u00f3pez AB, \u00c1lvarez Blanco O, Luque de Pablos A, et al. Ibuprofen-induced acute interstitial nephritis in the paediatric population. Nefrologia. 2016;36(1):69-71. https:\/\/doi.org\/10.1016\/j.nefro.2015.09.003","DOI":"10.1016\/j.nefro.2015.09.003"}],"container-title":["Ugeskrift for L\u00e6ger"],"original-title":[],"deposited":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T13:38:38Z","timestamp":1768570718000},"score":1,"resource":{"primary":{"URL":"https:\/\/ugeskriftet.dk\/videnskab\/V05250413"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,22]]},"references-count":4,"URL":"https:\/\/doi.org\/10.61409\/v05250413","relation":{},"ISSN":["0041-5782","1603-6824"],"issn-type":[{"value":"0041-5782","type":"print"},{"value":"1603-6824","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,22]]}}}