{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T00:50:10Z","timestamp":1768611010026,"version":"3.49.0"},"reference-count":4,"publisher":"Danish Medical Association","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ugeskr L\u00e6ger"],"abstract":"<jats:p>In this case report, we present an instance of an atypical femur fracture in a patient receiving denosumab treatment. Due to MRI-verified severe lateral recess stenosis, her symptoms are misinterpreted because of nerve root affection and treated as such with surgical decompression. Not until postoperatively was the atypical femur fracture of the left leg diagnosed and finally treated. With this case report, we aim to raise awareness of atypical femur fracture as a differential diagnosis for nerve root affection and explore the possible connection between denosumab and atypical femur fracture.<\/jats:p>","DOI":"10.61409\/v05250415","type":"journal-article","created":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T11:50:21Z","timestamp":1767613821000},"page":"1-5","source":"Crossref","is-referenced-by-count":0,"title":["Atypical femur fracture in denosumab treatment and as a rare differential diagnosis to nerve root affection"],"prefix":"10.61409","author":[{"given":"Christian Malling","family":"Longworth","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter Heide","family":"Pedersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annette Bennedsgaard","family":"Jespersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"40208","published-online":{"date-parts":[[2025,12,22]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"Bone HG, Wagman RB, Brandi ML et al. 10 years of denosumab treatment in postmenopausal women with osteoporosis: results from the phase 3 randomized FREEDOM trial and open-label extension. Lancet Diabetes Endocrinol. 2017;5(7):513-523. doi: https:\/\/doi.org\/10.1016\/S2213-8587(17)30138-9","DOI":"10.1016\/S2213-8587(17)30138-9"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Shane E, Burr D, Abrahamsen B et al. Atypical subtrochanteric and diaphyseal femoral fractures: second report of a task force of the American Society for Bone and Mineral Research. J Bone Miner Res. 2014;29(1):1-23. https:\/\/doi.org\/10.1002\/jbmr.1998","DOI":"10.1002\/jbmr.1998"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"Black DM, Condra K, Adams AL, Eastell R. Bisphosphonates and the risk of atypical femur fractures. Bone. 2022;156:116297. https:\/\/doi.org\/10.1016\/j.bone.2021.116297","DOI":"10.1016\/j.bone.2021.116297"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"Van de Laarschot D, McKenna MJ, Abrahamsen B et al. Medical management of patients after atypical femur fractures: a systematic review and recommendations from the European Calcified Tissue Society. J Clin Endocrinol Metab. 2020;105(5):1682-1699. doi: https:\/\/doi.org\/10.1210\/clinem\/dgz295","DOI":"10.1210\/clinem\/dgz295"}],"container-title":["Ugeskrift for L\u00e6ger"],"original-title":[],"deposited":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T13:41:03Z","timestamp":1768570863000},"score":1,"resource":{"primary":{"URL":"https:\/\/ugeskriftet.dk\/videnskab\/V05250415"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,22]]},"references-count":4,"URL":"https:\/\/doi.org\/10.61409\/v05250415","relation":{},"ISSN":["0041-5782","1603-6824"],"issn-type":[{"value":"0041-5782","type":"print"},{"value":"1603-6824","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,22]]}}}