{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T08:10:07Z","timestamp":1747901407873,"version":"3.41.0"},"reference-count":5,"publisher":"Danish Medical Association","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ugeskr L\u00e6ger"],"abstract":"<jats:p>In this case report, a 37-year-old female was admitted to hospital with fever and muscle pain two days after returning from Mauritius. Approximately two hours after first administration of intravenous ceftriaxone she suddenly developed respiratory and circulatory failure. Anaphylaxis and pulmonary embolism were considered and excluded. Initially she was treated as having sepsis and required respiratory and vasopressor support. She ended up testing positive for leptospirosis and it was concluded that the respiratory and circulatory failure was a Jarisch-Herxheimer reaction.<\/jats:p>","DOI":"10.61409\/v06240398","type":"journal-article","created":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T07:56:46Z","timestamp":1732262206000},"page":"1-5","source":"Crossref","is-referenced-by-count":0,"title":["Jarisch-Herxheimer reaction in a patient with leptospirosis"],"prefix":"10.61409","author":[{"given":"Henriette Vendelbo","family":"Graversen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carsten Schade","family":"Larsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sanne","family":"Jespersen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"40208","published-online":{"date-parts":[[2024,11,18]]},"reference":[{"key":"ref0","unstructured":"Statens Serum Institut. Leptospirose. Statens Serum Institut, 2024. www.ssi.dk\/sygdomme-beredskab-og-forskning\/sygdomsleksikon\/l\/leptospirose (2. apr 2024)."},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Butler T. The Jarisch-Herxheimer reaction after antibiotic treatment of spirochetal infections: a review of recent cases and our understanding of pathogenesis. Am J Trop Med Hyg. 2017;96(1):46-52. https:\/\/doi.org\/10.4269\/ajtmh.16-0434","DOI":"10.4269\/ajtmh.16-0434"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"Guerrier G, D'Ortenzio E. The Jarisch-Herxheimer reaction in leptospirosis: a systematic review. PLoS One. 2013;8(3):e59266. https:\/\/doi.org\/10.1371\/ journal.pone.0059266","DOI":"10.1371\/journal.pone.0059266"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"Stewart GC, Lopez-Molina J, Gottumukkala RVSRK et al. Myocardial parvovirus B19 persistence - lack of association with clinicopathologic phenotype in adults with heart failure. Circ Heart Fail. 2011;4(1):71-8. https:\/\/doi.org\/10.1161\/CIRCHEARTFAILURE.110.958249","DOI":"10.1161\/CIRCHEARTFAILURE.110.958249"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"Gurrier G, Lefevre P, Chouvin C et al. Jarisch-Herxheimer reaction among patients with leptospirosis: incidence and risk factors. Am J Trop Med Hyg. 2018;96(4): 791-794. https:\/\/doi.org\/10.4269\/ajtmh.16-0457","DOI":"10.4269\/ajtmh.16-0457"}],"container-title":["Ugeskrift for L\u00e6ger"],"original-title":[],"deposited":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T07:36:22Z","timestamp":1747899382000},"score":1,"resource":{"primary":{"URL":"https:\/\/ugeskriftet.dk\/videnskab\/V06240398"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,18]]},"references-count":5,"URL":"https:\/\/doi.org\/10.61409\/v06240398","relation":{},"ISSN":["0041-5782","1603-6824"],"issn-type":[{"type":"print","value":"0041-5782"},{"type":"electronic","value":"1603-6824"}],"subject":[],"published":{"date-parts":[[2024,11,18]]}}}