{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T08:18:31Z","timestamp":1781597911496,"version":"3.54.5"},"reference-count":18,"publisher":"Danish Medical Association","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ugeskr L\u00e6ger"],"abstract":"<jats:p>Spontaneous coronary artery dissection (SCAD) presents a life-threatening condition, prevalent among young women, comprising up to 35% of acute coronary syndrome cases. It involves sudden, trauma-free splitting of coronary artery walls, reducing blood flow and mimicking symptoms of acute myocardial infarction. Despite recent attention, treatment remains debated. Hormonal changes, stress, migraines, physical and psychological aspects impact the prognosis. Ongoing research aims to refine diagnostic and therapeutic approaches, addressing long-term outcomes. In this review, we have summarised current aspects of SCAD to increase awareness of the condition.<\/jats:p>","DOI":"10.61409\/v07240453","type":"journal-article","created":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T07:41:13Z","timestamp":1733730073000},"page":"1-6","source":"Crossref","is-referenced-by-count":1,"title":["Spontaneous coronary artery dissection"],"prefix":"10.61409","author":[{"given":"Karoline Bjerg","family":"Dam-Huus","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lene","family":"Holmvang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rikke","family":"S\u00f8rensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mette Gitz","family":"Charlot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolaj Brejnholt","family":"St\u00f8ttrup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lene H\u00fcche","family":"Nielsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lia Evi","family":"Bang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"40208","published-online":{"date-parts":[[2024,11,25]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"Hayes SN, Tweet MS, Adlam D et al. Spontaneous coronary artery dissection JACC state-of-the-art review. J Am Coll Cardiol. 2020;76(8):961-984. https:\/\/doi.org\/10.1016\/j.jacc.2020.05.084","DOI":"10.1016\/j.jacc.2020.05.084"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Hayes SN, Kim ESH, Saw J et al. Spontaneous coronary artery dissection: current state of the science. Circulation. 2018;137(19):5e23-e557. https:\/\/doi.org\/10.1161\/CIR.0000000000000564","DOI":"10.1161\/CIR.0000000000000564"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"Johnson AK, Tweet MS, Rouleau SG et al. The presentation of spontaneous coronary artery dissection in the emergency department: signs and symptoms in an unsuspecting population. Acad Emerg Med. 2022;29(4):423-428. https:\/\/doi.org\/10.1111\/acem.14426","DOI":"10.1111\/acem.14426"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"Adlam D, Berrandou TE, Georges A et al. Genome-wide association meta-analysis of spontaneous coronary artery dissection identifies risk variants and genes related to artery integrity and tissue-mediated coagulation. Nat Genet. 2023;55(6):964-972. https:\/\/doi.org\/10.1038\/s41588-023-01410-1","DOI":"10.1038\/s41588-023-01410-1"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"Saw J, Starovoytov A, Aymong E et al. Canadian spontaneous coronary artery dissection cohort study 3-year outcomes. J Am Coll Cardiol. 2022;80(17):1585-1597. https:\/\/doi.org\/10.1016\/j.jacc.2022.08.759","DOI":"10.1016\/j.jacc.2022.08.759"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"Kaddoura R, Cader FA, Ahmed A, Alasnag M. Spontaneous coronary artery dissection: an overview. Postgrad Med J. 2023;99(1178):1226-1236. https:\/\/doi.org\/10.1093\/postmj\/qgad086","DOI":"10.1093\/postmj\/qgad086"},{"key":"ref6","unstructured":"Sundhedsdatastyrelsen. SKS-opdatering ordin\u00e6r - januar 2020. https:\/\/sundhedsdatastyrelsen.dk\/-\/media\/sds\/filer\/rammer-og-retningslinjer\/klassifikationer\/sks-opdateringer\/tidligere-opdateringer\/sks_opdat_2020.pdf (8. maj 2024)"},{"key":"ref7","unstructured":"Dansk Cardiologisk Selskab. Spontan koronararterie dissektion (SCAD) - et holdningspapir fra Dansk Cardiologisk Selskab, 2024. https:\/\/www.cardio.dk\/media\/com_reditem\/files\/customfield\/item\/8149\/0de8ce2d4c1b780657e71f54cb1987fe7281352d.pdf (8. maj 2024)"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"Teruzzi G, Baldi GS, Gili S et al. Spontaneous coronary artery dissections: a systematic review. J Clin Med. 2021;10(24):5925. https:\/\/doi.org\/10.3390\/jcm10245925","DOI":"10.3390\/jcm10245925"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"Agwuegbo CC, Ahmed EN, Olumuyide E et al. Spontaneous coronary artery dissection: an updated comprehensive review. Cureus. 2024;16(2):e55106. https:\/\/doi.org\/10.7759\/cureus.55106","DOI":"10.7759\/cureus.55106"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"Thygesen K, Alpert JS, Jaffe AS et al. Fourth universal definition of myocardial infarction (2018). Eur Heart J. 2019;40(3):237-269. https:\/\/doi.org\/10.1093\/eurheartj\/ehy462","DOI":"10.1093\/eurheartj\/ehy462"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"Adlam D, Alfonso F, Maas A, Vrints C, Writing Committee. European Society of Cardiology, acute cardiovascular care association, SCAD study group: a position paper on spontaneous coronary artery dissection. Eur J Heart. 2018;39(36):3353-3368. https:\/\/doi.org\/10.1093\/eurheartj\/ehy080","DOI":"10.1093\/eurheartj\/ehy080"},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"Byrne RA, Rossello X, Coughlan JJ et al. 2023 ESC Guidelines for the management of acute coronary syndromes. Eur Heart J. 2023;44(38):3720-3826. https:\/\/doi.org\/10.1093\/eurheartj\/ehad191","DOI":"10.1093\/eurheartj\/ehad191"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"Murphy BM, Rogerson MC, Hesselson S et al. Psychosocial impacts of spontaneous coronary artery dissection: a qualitative study. PLoS One. 2022;17(9):e273978. https:\/\/doi.org\/10.1371\/journal.pone.0273978","DOI":"10.1371\/journal.pone.0273978"},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"Binnie K, Neubeck L, McHale S, Hanson CL. What do spontaneous coronary artery dissection survivors want to support their recovery? Eur J Cardiovascr Nurs. 2023;22(8):814-823. https:\/\/doi.org\/10.1093\/eurjcn\/zvad013","DOI":"10.1093\/eurjcn\/zvad013"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"Sharma S, Kaadan MI, Duran JM et al. Risk factors, imaging findings, and sex differences in spontaneous coronary artery dissection. Am J Cardiol. 2019;123(11):1783-1787. https:\/\/doi.org\/10.1016\/j.amjcard.2019.02.040","DOI":"10.1016\/j.amjcard.2019.02.040"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"Djokovic A, Krljanac G, Matic P et al. Pathophysiology of spontaneous coronary artery dissection: hematoma, not thrombus. Front Cardiovasc Med. 2023;10:1260478. https:\/\/doi.org\/10.3389\/fcvm.2023.1260478","DOI":"10.3389\/fcvm.2023.1260478"},{"key":"ref17","unstructured":"Hjerteforeningen. Ladywalk | Danmarks st\u00f8rste motionsevent for kvinder, 2024. https:\/\/ladywalk.dk\/ (27. maj 2024)"}],"container-title":["Ugeskrift for L\u00e6ger"],"original-title":[],"deposited":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T08:06:52Z","timestamp":1747901212000},"score":1,"resource":{"primary":{"URL":"https:\/\/ugeskriftet.dk\/videnskab\/V07240453"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11,25]]},"references-count":18,"URL":"https:\/\/doi.org\/10.61409\/v07240453","relation":{},"ISSN":["0041-5782","1603-6824"],"issn-type":[{"value":"0041-5782","type":"print"},{"value":"1603-6824","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,11,25]]}}}