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This review discusses current treatment recommendations and research perspectives.<\/jats:p>","DOI":"10.61409\/v07250588","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T10:39:09Z","timestamp":1775731149000},"page":"1-9","source":"Crossref","is-referenced-by-count":0,"title":["Motion sickness"],"prefix":"10.61409","author":[{"given":"Asher Lou","family":"Isenberg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louie","family":"Rogalla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mads","family":"Klokker","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e5ns","family":"Magnusson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"40208","published-online":{"date-parts":[[2026,4,6]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"Schmidt EA, Kuiper OX, Wolter S et al. 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Science. 1977;197(4302):493-5. https:\/\/doi.org\/10.1126\/science.301659","DOI":"10.1126\/science.301659"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"Paillard AC, Quarck G, Paolino F et al. Motion sickness susceptibility in healthy subjects and vestibular patients: effects of gender, age and trait-anxiety. J Vestib Res. 2013;23(4-5):203-9. https:\/\/doi.org\/10.3233\/VES-130501","DOI":"10.3233\/VES-130501"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"Golding JF. Motion sickness. Handb Clin Neurol. 2016;137:371-90. https:\/\/doi.org\/10.1016\/B978-0-444-63437-5.00027-3","DOI":"10.1016\/B978-0-444-63437-5.00027-3"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"Teaford M, Keller K, Merfeld DM. The contribution of interoceptive signals to spatial orientation: a mini-review. 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Electrek, 2024. https:\/\/electrek.co\/2024\/12\/19\/check-out-kia-ev6s-new-virtual-gear-shift-feature-video\/ (1. jul 2025)"},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"Haniadka R, Saldanha E, Sunita V et al. A review of the gastroprotective effects of ginger (Zingiber officinale Roscoe). Food Funct. 2013;4(6):845-55. https:\/\/doi.org\/10.1039\/c3fo30337c","DOI":"10.1039\/c3fo30337c"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"Lu H, Zheng C, Zhong Y et al. Effectiveness of acupuncture in the treatment of hyperemesis gravidarum: a systematic review and meta-analysis. Evid Based Complement Alternat Med. 2021;2021:2731446. https:\/\/doi.org\/10.1155\/2021\/2731446","DOI":"10.1155\/2021\/2731446"},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"Lee A, Chan SKC, Fan LTY. Stimulation of the wrist acupuncture point PC6 for preventing postoperative nausea and vomiting. 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Mil Med. 2015;180(11):1135-9. https:\/\/doi.org\/10.7205\/MILMED-D-14-00315","DOI":"10.7205\/MILMED-D-14-00315"},{"key":"ref25","doi-asserted-by":"publisher","unstructured":"Karrim N, Byrne R, Magula N, Saman Y. Antihistamines for motion sickness. Cochrane Database Syst Rev. 2022;10(10):CD012715. https:\/\/doi.org\/10.1002\/14651858.CD012715.pub2","DOI":"10.1002\/14651858.CD012715.pub2"},{"key":"ref26","doi-asserted-by":"publisher","unstructured":"Spinks A, Wasiak J. Scopolamine (hyoscine) for preventing and treating motion sickness. Cochrane Database Syst Rev. 2011;2011(6):CD002851. https:\/\/doi.org\/10.1002\/14651858.CD002851.pub4","DOI":"10.1002\/14651858.CD002851.pub4"},{"key":"ref27","unstructured":"Brainard A, Gresham C. Prevention and treatment of motion sickness. Am Fam Physician. 2014;90(1):41-6"},{"key":"ref28","doi-asserted-by":"publisher","unstructured":"Viola P, Marcian\u00f2 G, Casarella A et al. The pharmacological treatment of pediatric vertigo. 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