{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T15:21:36Z","timestamp":1773933696995,"version":"3.50.1"},"reference-count":5,"publisher":"Danish Medical Association","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ugeskr L\u00e6ger"],"abstract":"<jats:p>This case report describes a 69-year-old woman on long-term pantoprazole therapy, initially prescribed for nonspecific upper gastrointestinal symptoms. Despite resistance to discontinuation due to rebound symptoms, a gradual dose reduction combined with patient education and use of antacids led to successful cessation. The case highlights the importance of regular medication review, patient involvement, and awareness of rebound acid hypersecretion in facilitating rational PPI use and deprescribing efforts.<\/jats:p>","DOI":"10.61409\/v08250629","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T07:46:54Z","timestamp":1773301614000},"page":"1-3","source":"Crossref","is-referenced-by-count":0,"title":["Discontinuation of long-term proton pump inhibitor treatment"],"prefix":"10.61409","author":[{"given":"Peter Fentz","family":"Haastrup","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorte Ejg","family":"Jarb\u00f8l","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"40208","published-online":{"date-parts":[[2026,3,2]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"L\u00f8drup AB, Reimer C, Bytzer P. Systematic review: symptoms of rebound acid hypersecretion following proton pump inhibitor treatment. Scand J Gastroenterol. 2013 May;48(5):515-522. https:\/\/doi.org\/10.3109\/00365521.2012.746395","DOI":"10.3109\/00365521.2012.746395"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Kurlander JE, Kennedy JK, Rubenstein JH, et al. Patients' perceptions of proton pump inhibitor risks and attempts at discontinuation: a national survey. Am J Gastroenterol. 2019;114(2):244-249. https:\/\/doi.org\/10.14309\/ajg.0000000000000061","DOI":"10.14309\/ajg.0000000000000061"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"Targownik LE, Fisher DA, Saini SD. AGA clinical practice update on de-prescribing of proton pump inhibitors: expert review. Gastroenterology. 2022;162(4):1334-1342. https:\/\/doi.org\/10.1053\/j.gastro.2021.12.247","DOI":"10.1053\/j.gastro.2021.12.247"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"Bj\u00f6rnsson E, Abrahamsson H, Simr\u00e9n M, et al. Discontinuation of proton pump inhibitors in patients on long-term therapy: a double-blind, placebo-controlled trial. Aliment Pharmacol Ther. 2006;24(6):945-954. https:\/\/doi.org\/10.1111\/j.1365-2036.2006.03084.x","DOI":"10.1111\/j.1365-2036.2006.03084.x"},{"key":"ref4","unstructured":"Dansk Selskab for Almen Medicin. Dyspepsi og gastro\u00f8sofageal reflukssygdom hos voksne - udredning og behandling. K\u00f8benhavn, 2021. https:\/\/www.dsam.dk\/vejledninger\/dyspepsi"}],"container-title":["Ugeskrift for L\u00e6ger"],"original-title":[],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T13:02:20Z","timestamp":1773925340000},"score":1,"resource":{"primary":{"URL":"https:\/\/ugeskriftet.dk\/videnskab\/V08250629"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3,2]]},"references-count":5,"URL":"https:\/\/doi.org\/10.61409\/v08250629","relation":{},"ISSN":["0041-5782","1603-6824"],"issn-type":[{"value":"0041-5782","type":"print"},{"value":"1603-6824","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3,2]]}}}