{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T14:42:38Z","timestamp":1773931358805,"version":"3.50.1"},"reference-count":5,"publisher":"Danish Medical Association","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ugeskr L\u00e6ger"],"abstract":"<jats:p>Encorafenib, cetuximab, and binimetinib are targeted therapies developed for metastatic colorectal cancer with a BRAF V600E mutation. This case report describes a patient with metastatic duodenal cancer with a BRAF V600E mutation who achieved durable complete remission following this treatment. The case highlights the potential use of BRAF V600E targeted therapy in BRAF V600E-mutated duodenal cancer and the importance of molecular profiling in rare cancers. Further research is needed on the effect and safety of targeted therapy for small bowel adenocarcinoma.<\/jats:p>","DOI":"10.61409\/v08250650","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T07:03:02Z","timestamp":1769670182000},"page":"1-3","source":"Crossref","is-referenced-by-count":0,"title":["Remission of metastatic duodenal cancer after treatment with BRAF inhibitor"],"prefix":"10.61409","author":[{"given":"Helene Benedikte","family":"Hansen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia Almer","family":"Bromann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"H\u00f8gdall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jakob Hagen Vasehus","family":"Schou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rikke","family":"Eefsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"40208","published-online":{"date-parts":[[2026,1,26]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"Pedersen KS, Raghav K, Overman MJ. Small bowel adenocarcinoma: etiology, presentation, and molecular alterations. J Natl Compr Canc Netw. 2019;17(9):1135-1141. https:\/\/doi.org\/10.6004\/jnccn.2019.7344","DOI":"10.6004\/jnccn.2019.7344"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Kopetz S, Grothey A, Yaeger R, et al. Encorafenib, binimetinib, and cetuximab in BRAF V600E-mutated colorectal cancer. N Engl J Med. 2019;381(17):1632-1643. https:\/\/doi.org\/10.1056\/NEJMoa1908075","DOI":"10.1056\/NEJMoa1908075"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"Tabernero J, Grothey A, Van Cutsem E, et al. Encorafenib plus cetuximab as a new standard of care for previously treated BRAF V600E-mutant metastatic colorectal cancer: updated survival results and subgroup analyses from the BEACON study. J Clin Oncol. 2021;39(4):273-284. https:\/\/doi.org\/10.1200\/JCO.20.02088","DOI":"10.1200\/JCO.20.02088"},{"key":"ref3","unstructured":"Danske Multidisciplin\u00e6re Cancer Grupper og Regionernes Kliniske Kvalitetsudviklingsprogram. Medicinsk onkologisk behandling af metastaserende kolorektal cancer, 2023. Dansk Multidisciplin\u00e6r Cancer Gruppe (DMCG). Tilg\u00e6ngelig https:\/\/www.dmcg.dk\/siteassets\/kliniske-retningslinjer---skabeloner-og-vejledninger\/kliniske-retningslinjer-opdelt-pa-dmcg\/dccg\/dccg_med_onk_beh_meta_kol_v1.0_admgodk181023.pdf (14. nov 2025)"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"Kopetz S, Yoshino T, Van Cutsem E, et al. Encorafenib, cetuximab, and chemotherapy in BRAF-mutant colorectal cancer: a randomized phase 3 trial. Nat Med. 2025;31(6):901-908. https:\/\/doi.org\/10.1038\/s41591-024-03443-3","DOI":"10.1038\/s41591-024-03443-3"}],"container-title":["Ugeskrift for L\u00e6ger"],"original-title":[],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T12:00:16Z","timestamp":1773921616000},"score":1,"resource":{"primary":{"URL":"https:\/\/ugeskriftet.dk\/videnskab\/V08250650"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,26]]},"references-count":5,"URL":"https:\/\/doi.org\/10.61409\/v08250650","relation":{},"ISSN":["0041-5782","1603-6824"],"issn-type":[{"value":"0041-5782","type":"print"},{"value":"1603-6824","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,26]]}}}