{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T23:35:58Z","timestamp":1768606558903,"version":"3.49.0"},"reference-count":5,"publisher":"Danish Medical Association","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ugeskr L\u00e6ger"],"abstract":"<jats:p>The topical calcium channel blocker diltiazem gel is among the most frequently used medical treatments for anal fissures. A known side effect of diltiazem gel is contact dermatitis. This case report presents a 44-year-old woman, who was assessed by several different specialities, due to persistent perianal symptoms, while treated intermittently with diltiazem gel for an anal fissure. After 18 months, the patient was diagnosed with complicating allergic contact dermatitis caused by diltiazem gel.<\/jats:p>","DOI":"10.61409\/v08250669","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T08:44:08Z","timestamp":1767948248000},"page":"1-5","source":"Crossref","is-referenced-by-count":0,"title":["A prolonged diagnostic examination of anal fissure with complicating contact dermatitis"],"prefix":"10.61409","author":[{"given":"Camilla","family":"M\u00f8ller","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sebastian Vigand","family":"Svendsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evy","family":"Paulsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth","family":"Thomsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"40208","published-online":{"date-parts":[[2026,1,5]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"Mapel DW, Schum M, Von Worley A. The epidemiology and treatment of anal fissures in a population-based cohort. BMC Gastroenterol. 2014;14:129. https:\/\/doi.org\/10.1186\/1471-230X-14-129","DOI":"10.1186\/1471-230X-14-129"},{"key":"ref1","unstructured":"Bundgaard NS, Hagen KK, Nordholm-Carstensen A. Behandling af analfissurer. Ugeskr L\u00e6ger. 2017;179:V05170384"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"Roelandt P, Bislenghi G, Coremans G, et al. Belgian consensus guideline on the management of anal fissures. Acta Gastroenterol Belg. 2024;87(2):304-321. https:\/\/doi.org\/10.51821\/87.2.11787","DOI":"10.51821\/87.2.11787"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"Nordholm-Carstensen A, Perregaard H, Wahlstr\u00f8m KL, et al. Treatment of chronic anal fissure: a feasibility study on Levorag\u00ae Emulgel versus Diltiazem gel 2. Int J Colorectal Dis. 2020;35(4):615-621. https:\/\/doi.org\/10.1007\/s00384-020-03515-z","DOI":"10.1007\/s00384-020-03515-z"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"Leinonen PT, Riekki R, Oikarinen A. Contact allergy to diltiazem cream. Contact Dermatitis. 2010;63(4):228-230. https:\/\/doi.org\/10.1111\/j.1600-0536.2010.01806.x","DOI":"10.1111\/j.1600-0536.2010.01806.x"}],"container-title":["Ugeskrift for L\u00e6ger"],"original-title":[],"deposited":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T13:50:27Z","timestamp":1768571427000},"score":1,"resource":{"primary":{"URL":"https:\/\/ugeskriftet.dk\/videnskab\/V08250669"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,5]]},"references-count":5,"URL":"https:\/\/doi.org\/10.61409\/v08250669","relation":{},"ISSN":["0041-5782","1603-6824"],"issn-type":[{"value":"0041-5782","type":"print"},{"value":"1603-6824","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,5]]}}}