{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T02:10:40Z","timestamp":1769566240492,"version":"3.49.0"},"reference-count":5,"publisher":"Danish Medical Association","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ugeskr L\u00e6ger"],"abstract":"<jats:p>We present a case of sporadic Creutzfeldt-Jakob disease (sCJD) in a 73-year-old patient, in which initial suspicion arose from unusual magnetic resonance imaging (MRI) findings and was later confirmed by cerebrospinal fluid analysis. This case report highlights the role of MRI in the early diagnosis of sCJD, facilitating timely palliative care, and highlights the key clinical and imaging characteristics of this rare and fatal prion disease.<\/jats:p>","DOI":"10.61409\/v08250698","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T09:01:31Z","timestamp":1769072491000},"page":"1-4","source":"Crossref","is-referenced-by-count":0,"title":["MRI as a key for early diagnosis of Creutzfeldt-Jakob disease"],"prefix":"10.61409","author":[{"given":"Fabiana Andrade","family":"Melchiori","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olha","family":"Zhygynas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harro","family":"Bitterling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"40208","published-online":{"date-parts":[[2026,1,19]]},"reference":[{"key":"ref0","unstructured":"Statens Serum Institut. Nationale infektionshygiejniske retningslinjer: prionsygdom - forebyggelse i sundhedssektoren, 2023. https:\/\/hygiejne.ssi.dk\/NIRprionsygdom (29. sep 2025)"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Hermann P, Appleby B, Brandel JP et al. Biomarkers and diagnostic guidelines for sporadic Creutzfeldt-Jakob disease. Lancet Neurol. 2021;20(3):235-246. https:\/\/doi.org\/10.1016\/S1474-4422(20)30477-4","DOI":"10.1016\/S1474-4422(20)30477-4"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"Macfarlane RG, Wroe SJ, Collinge J et al. Neuroimaging findings in human prion disease. J Neurol Neurosurg Psychiatry. 2007;78(7):664-70. https:\/\/doi.org\/10.1136\/jnnp.2006.094821","DOI":"10.1136\/jnnp.2006.094821"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"Park HY, Kim M, Suh CH et al. Diagnostic value of diffusion-weighted brain magnetic resonance imaging in patients with sporadic Creutzfeldt-Jakob disease: a systematic review and meta-analysis. Eur Radiol. 2021;31(12):9073-9085. https:\/\/doi.org\/10.1007\/s00330-021-08031-4","DOI":"10.1007\/s00330-021-08031-4"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"Henkel K, Zerr I, Hertel A et al. Positron emission tomography with [(18)F]FDG in the diagnosis of Creutzfeldt-Jakob disease (CJD). J Neurol. 2002;249(6):699-705. https:\/\/doi.org\/10.1007\/s00415-002-0695-3","DOI":"10.1007\/s00415-002-0695-3"}],"container-title":["Ugeskrift for L\u00e6ger"],"original-title":[],"deposited":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T13:49:32Z","timestamp":1769521772000},"score":1,"resource":{"primary":{"URL":"https:\/\/ugeskriftet.dk\/videnskab\/V08250698"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,19]]},"references-count":5,"URL":"https:\/\/doi.org\/10.61409\/v08250698","relation":{},"ISSN":["0041-5782","1603-6824"],"issn-type":[{"value":"0041-5782","type":"print"},{"value":"1603-6824","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,19]]}}}