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We propose that visible anoxic-ischaemic encephalopathy on brain CT after cardiac arrest does not require evaluation by ancillary testing, and that CT-angiography can be used instead of DSA.<\/jats:p>","DOI":"10.61409\/v11230695","type":"journal-article","created":{"date-parts":[[2024,6,10]],"date-time":"2024-06-10T08:35:03Z","timestamp":1718008503000},"page":"1-8","source":"Crossref","is-referenced-by-count":1,"title":["Criteria for brain death in Denmark"],"prefix":"10.61409","author":[{"given":"Jesper","family":"Kelsen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen Irgens Tanderup","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas Hjelm","family":"Brandt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Birkeland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marwan H.","family":"Othman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trine","family":"Stavngaard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niels","family":"Agerlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Kondziella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"40208","published-online":{"date-parts":[[2024,5,27]]},"reference":[{"key":"ref0","unstructured":"Det Etiske R\u00e5d. Organdonation. Etiske overvejelser og anbefalinger. Det Etiske R\u00e5d, 2008. www.nationaltcenterforetik.dk\/Media\/637880542060508641\/organdonation.pdf (mar 2024)"},{"key":"ref1","unstructured":"Heissel A. L\u00e6ger \u00e5bne for organdonation fra hjerted\u00f8de. Ugeskr L\u00e6ger. 2017. ugeskriftet.dk\/nyhed\/laeger-abne-organdonation-fra-hjertedode (mar 2024)"},{"key":"ref2","unstructured":"S\u00f8rensen AE, Olesen NW. Indf\u00f8relsen af hjerned\u00f8dskriteriet, 1990. www.danmarkshistorien.dk\/vis\/materiale\/indfoerelsen-af-hjernedoedskriteriet-1990 (mar 2024)"},{"key":"ref3","unstructured":"Indenrigs- og Sundhedsministeriet. Lov om ligsyn, obduktion, transplantation m.v. LOV nr 402 af 13\/06\/1990. www.retsinformation.dk\/eli\/lta\/1990\/402 (mar 2024)"},{"key":"ref4","unstructured":"Indenrigs- og Sundhedsministeriet. Cirkul\u00e6re om d\u00f8dens konstatering ved uopretteligt oph\u00f8r af al hjernefunktion. CIR nr 118 af 25\/06\/1990. www.retsinformation.dk\/eli\/mt\/1990\/118 (mar 2024)"},{"key":"ref5","unstructured":"Dansk Center for Organdonation. Tal 2013-2022. www.organdonation.dk\/tal\/tal-2014-2023\/ (mar 2024)"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"Kondziella D. The neurology of death and the dying brain: a pictorial essay. Front Neurol. 2020;11:736. https:\/\/doi.org\/10.3389\/fneur.2020.00736","DOI":"10.3389\/fneur.2020.00736"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"Othman MH, Dutta A, Kondziella D. Public opinion and legislations related to brain death, circulatory death and organ donation. J Neurol Sci. 2020;413:116800. https:\/\/doi.org\/10.1016\/j.jns.2020.116800","DOI":"10.1016\/j.jns.2020.116800"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"Greer DM, Shemie SD, Lewis A et al. Determination of brain death\/death by neurologic criteria. 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Bekendtg\u00f8relse om d\u00f8dens konstatering ved uopretteligt oph\u00f8r af al hjernefunktion. BEK nr 1249 af 06\/12\/2006. www.retsinformation.dk\/eli\/lta\/2006\/1249 (mar 2024)"},{"key":"ref13","unstructured":"Dansk Center for Organdonation. National guideline for organdonation. Dansk Center for Organdonation, 2023. www.organdonation.dk\/guideline\/ (mar 2024)"},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"Hansen KIT, Kelsen J, Othman MH et al. Confirmatory digital subtraction angiography after clinical brain death\/death by neurological criteria: impact on number of donors and organ transplants. PeerJ. 2023;11:e15759. https:\/\/doi.org\/10.7717\/peerj.15759","DOI":"10.7717\/peerj.15759"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"Kapinos G, Ala TA. When determining brain death in adults, time is of the essence! The last nail in the coffin of dual examination in brain death. Neurology. 2021;96(10):469-470. https:\/\/doi.org\/10.1212\/WNL.0000000000011594","DOI":"10.1212\/WNL.0000000000011594"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"Varelas PN, Rehman M, Mehta C et al. Comparison of 1 vs 2 brain death examinations on time to death pronouncement and organ donation: a 12-year single center experience. Neurology. 2021;96(10):e1453-e1461. https:\/\/doi.org\/10.1212\/WNL.0000000000011554","DOI":"10.1212\/WNL.0000000000011554"},{"issue":"26","key":"ref17","doi-asserted-by":"publisher","first-page":"2689","DOI":"10.1056\/NEJM200306263482618","article-title":"Diffuse cerebral infarction after cardiac arrest","volume":"348","author":"Correction","year":"2003","unstructured":"Correction. Diffuse cerebral infarction after cardiac arrest. N Engl J Med. 2003;348(26):2689.","journal-title":"N Engl J Med"},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"Kelsen J, Obel A. Images in clinical medicine. Fatal cerebral hypoxemia after cardiac arrest. N Engl J Med. 2003;348(9):817. https:\/\/doi.org\/10.1056\/NEJMicm020544","DOI":"10.1056\/NEJMicm020544"},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"Bohatyrewicz R, Sawicki M, Walecka A et al. Computed tomographic angiography and perfusion in the diagnosis of brain death. Transplant Proc. 2010;42(10):3941-6. https:\/\/doi.org\/10.1016\/j.transproceed.2010.09.143","DOI":"10.1016\/j.transproceed.2010.09.143"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"Garrett MP, Williamson RW, Bohl MA et al. Computed tomography angiography as a confirmatory test for the diagnosis of brain death. J Neurosurg. 2018;128(2):639-644. https:\/\/doi.org\/10.3171\/2016.10.JNS161042","DOI":"10.3171\/2016.10.JNS161042"},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"Rieke A, Regli B, Mattle H et al. Computed tomography angiography (CTA) to prove circulatory arrest for the diagnosis of brain death in the context of organ transplantation. Swiss Med Wkly. 2011;141:w13261. https:\/\/doi.org\/10.4414\/smw.2011.13261","DOI":"10.4414\/smw.2011.13261"},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"Bohatyrewicz R, Pastuszka J, Walas W et al. Implementation of computed tomography angiography (CTA) and computed tomography perfusion (CTP) in polish guidelines for determination of cerebral circulatory arrest (CCA) during brain death\/death by neurological criteria (BD\/DNC) diagnosis procedure. J Clin Med. 2021;10(18):4237. https:\/\/doi.org\/10.3390\/jcm10184237","DOI":"10.3390\/jcm10184237"},{"key":"ref23","unstructured":"Neurocritical Care Society. Brain death toolkit. www.neurocriticalcare.org\/NCS-Learning-Center\/Learning-Center\/Results\/Details\/brain-death-toolkit (mar 2024)"},{"key":"ref24","unstructured":"Neurocritical Care Society. 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