{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T19:49:37Z","timestamp":1761767377654,"version":"3.40.5"},"reference-count":29,"publisher":"Danish Medical Association","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ugeskr L\u00e6ger"],"abstract":"<jats:p>Aortic valve replacement is the common treatment of choice for severe aortic valve insufficiency (AI). AI is often caused by aortic root dilatation which leads to valve incompetence despite structurally normal valve leaflets. For this condition, aortic repair surgery with ring annuloplasty is considered a potentially superior option. Despite the availability of different annuloplasty rings, no guidelines for the surgical procedure nor the choice of annuloplasty ring exist. In this review, we outline the surgical treatment using valve-preserving procedures as an alternative to conventional aortic valve replacement.<\/jats:p>","DOI":"10.61409\/v11230740","type":"journal-article","created":{"date-parts":[[2024,10,29]],"date-time":"2024-10-29T13:14:22Z","timestamp":1730207662000},"page":"1-8","source":"Crossref","is-referenced-by-count":1,"title":["Aortic valve replacement in younger patients with aortic valve insuffienciency"],"prefix":"10.61409","author":[{"given":"Tanita Drejer","family":"Jeppesen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Hasbak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. Michael","family":"Hasenkam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leila Louise","family":"Benhassen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"40208","published-online":{"date-parts":[[2024,9,30]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"Singh JP, Evans JC, Levy D et al. Prevalence and clinical determinants of mitral, tricuspid, and aortic regurgitation (the Framingham Heart Study). Am J Cardiol. 1999;83(6):897-902. Singh JP, Evans JC, Levy D et al. Prevalence and clinical determinants of mitral, tricuspid, and aortic regurgitation (the Framingham Heart Study). Am J Cardiol. 1999;83(6):897-902. https:\/\/doi.org\/10.1016\/S0002-9149(98)01064-9","DOI":"10.1016\/S0002-9149(98)01064-9"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Flint N, Wunderlich NC, Shmueli H et al. Aortic Regurgitation. Curr Cardiol Rep. 2019;21(7):65. https:\/\/doi.org\/10.1007\/s11886-019-1144-6","DOI":"10.1007\/s11886-019-1144-6"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"Rahimtoola SH. Choice of prosthetic heart valve for adult patients. J Am Coll Cardiol. 2003;41(6):893-904.https:\/\/doi.org\/10.1016\/S0735-1097(02)02965-0","DOI":"10.1016\/S0735-1097(02)02965-0"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"Girdauskas E, Petersen J, Balaban \u00dc et al. Outcomes of aortic valve repair: early results from the German Aortic Valve Registry. Eur J Cardiothorac Surg. 2022;62(4)ezac416. https:\/\/doi.org\/10.1093\/ejcts\/ezac416","DOI":"10.1093\/ejcts\/ezac416"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"Boodhwani M, El Khoury G. Aortic valve repair: indications and outcomes. Curr Cardiol Rep. 2014;16(6):490. https:\/\/doi.org\/10.1007\/s11886-014-0490-7","DOI":"10.1007\/s11886-014-0490-7"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"Haydar HS, He GW, Hovaguimian H et al. Valve repair for aortic insufficiency: surgical classification and techniques. Eur J Cardiothorac Surg. 1997;11(2):258-565. https:\/\/doi.org\/10.1016\/S1010-7940(96)01014-7","DOI":"10.1016\/S1010-7940(96)01014-7"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"Shimizu H, Yozu R. Valve-sparing aortic root replacement. Ann Thorac Cardiovasc Surg. 2011;17(4):330-336 .https:\/\/doi.org\/10.5761\/atcs.ra.11.01675","DOI":"10.5761\/atcs.ra.11.01675"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"Sievers HH, Hemmer W, Beyersdorf F et al. The everyday used nomenclature of the aortic root components: the tower of Babel? Eur J Cardiothorac Surg. 2012;41(3):478-482. https:\/\/doi.org\/10.1093\/ejcts\/ezr093","DOI":"10.1093\/ejcts\/ezr093"},{"key":"ref8","unstructured":"https:\/\/www.cardio.dk\/hjerteklapsygdom-2023#63-aortainsufficiens-ai (20. jun2023)."},{"key":"ref9","unstructured":"Olsen PS, Kimose HH. Kirurgi. Fadl's Forlag 2012:681-683."},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"Chan V, Malas T, Lapierre H et al. Reoperation of left heart valve bioprostheses according to age at implantation. Circulation. 2011;124(11 Suppl):S75-S80. https:\/\/doi.org\/10.1161\/CIRCULATIONAHA.110.011973","DOI":"10.1161\/CIRCULATIONAHA.110.011973"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"Calderwood SB, Swinski LA, Waternaux CM et al. Risk factors for the development of prosthetic valve endocarditis. Circulation. 1985;72(1):31-37. https:\/\/doi.org\/10.1161\/01.CIR.72.1.31","DOI":"10.1161\/01.CIR.72.1.31"},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"Kvidal P, Bergstr\u00f6m R, H\u00f6rte LG, St\u00e5hle E. Observed and relative survival after aortic valve replacement. J Am Coll Cardiol. 2000;35(3):747-756. https:\/\/doi.org\/10.1016\/S0735-1097(99)00584-7","DOI":"10.1016\/S0735-1097(99)00584-7"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"Bouhout I, Stevens LM, Mazine A et al. Long-term outcomes after elective isolated mechanical aortic valve replacement in young adults. J Thorac Cardiovasc Surg. 2014;148(4):1341-1346.e1. https:\/\/doi.org\/10.1016\/j.jtcvs.2013.10.064","DOI":"10.1016\/j.jtcvs.2013.10.064"},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"Hammermeister K, Sethi GK, Henderson WG et al. Outcomes 15 years after valve replacement with a mechanical versus a bioprosthetic valve: final report of the Veterans Affairs randomized trial. J Am Coll Cardiol. 2000;36(4):1152-1158. https:\/\/doi.org\/10.1016\/S0735-1097(00)00834-2","DOI":"10.1016\/S0735-1097(00)00834-2"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"Aicher D, Fries R, Rodionycheva S et al. Aortic valve repair leads to a low incidence of valve-related complications. Eur J Cardiothorac Surg. 2010;37(1):127-132. https:\/\/doi.org\/10.1016\/j.ejcts.2009.06.021","DOI":"10.1016\/j.ejcts.2009.06.021"},{"key":"ref16","doi-asserted-by":"publisher","unstructured":"Lansac E, Di Centa I, Danial P et al. Aortic valve repair versus mechanical valve replacement for root aneurysm: the CAVIAAR multicentric study. Eur J Cardiothorac Surg. 2022;62(2). https:\/\/doi.org\/10.1093\/ejcts\/ezac283","DOI":"10.1093\/ejcts\/ezac283"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"Lansac E, Di Centa I, Sleilaty G et al. Long-term results of external aortic ring annuloplasty for aortic valve repair. Eur J Cardiothorac Surg. 2016;50(2):ezac283. https:\/\/doi.org\/10.1093\/ejcts\/ezw070","DOI":"10.1093\/ejcts\/ezw070"},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"Lansac E, Di Centa I, Sleilaty G et al. Remodeling root repair with an external aortic ring annuloplasty. J Thorac Cardiovasc Surg. 2017;153(5):1033-1042. https:\/\/doi.org\/10.1016\/j.jtcvs.2016.12.031","DOI":"10.1016\/j.jtcvs.2016.12.031"},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"Salvig CD, Benhassen LL, Nygaard JV et al. The importance of collagen composition and biomechanics for the porcine aortic root. J Biomech. 2020;111:110009. https:\/\/doi.org\/10.1016\/j.jbiomech.2020.110009","DOI":"10.1016\/j.jbiomech.2020.110009"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"Youssefi P, El-Hamamsy I, Lansac E. Rationale for aortic annuloplasty to standardise aortic valve repair. Ann Cardiothorac Surg. 2019;8(3):322-330. https:\/\/doi.org\/10.21037\/acs.2019.05.13","DOI":"10.21037\/acs.2019.05.13"},{"key":"ref21","unstructured":"Charitos EI, Sievers HH. Anatomy of the aortic root: implications for valve-sparing surgery. Ann Cardiothorac Surg. 2013;2(1):53-56."},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"Lansac E, Di Centa I, Raoux F et al. An expansible aortic ring for a physiological approach to conservative aortic valve surgery. J Thorac Cardiovasc Surg. 2009;138(3):718-724 .https:\/\/doi.org\/10.1016\/j.jtcvs.2009.05.024","DOI":"10.1016\/j.jtcvs.2009.05.024"},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"Benhassen LL, Ropcke DM, Sharghbin M et al. Comparison of Dacron ring and suture annuloplasty for aortic valve repair-a porcine study. Ann Cardiothorac Surg. 2019;8(3):342-350. https:\/\/doi.org\/10.21037\/acs.2019.04.02","DOI":"10.21037\/acs.2019.04.02"},{"key":"ref24","doi-asserted-by":"publisher","unstructured":"Basmadjian L, Basmadjian AJ, Stevens LM et al. Early results of extra-aortic annuloplasty ring implantation on aortic annular dimensions. J Thorac Cardiovasc Surg. 2016;151(5):1280-5.e1. https:\/\/doi.org\/10.1016\/j.jtcvs.2015.12.014","DOI":"10.1016\/j.jtcvs.2015.12.014"},{"key":"ref25","doi-asserted-by":"publisher","unstructured":"Treasure T, Takkenberg JJ, Golesworthy T et al. Personalised external aortic root support (PEARS) in Marfan syndrome: analysis of 1-9\u2005year outcomes by intention-to-treat in a cohort of the first 30 consecutive patients to receive a novel tissue and valve-conserving procedure, compared with the published results of aortic root replacement. Heart. 2014;100(12):969-975. https:\/\/doi.org\/10.1136\/heartjnl-2013-304913","DOI":"10.1136\/heartjnl-2013-304913"},{"key":"ref26","unstructured":"Lansac E, Di Centa I, Vojacek J et al. Valve sparing root replacement: the remodeling technique with external ring annuloplasty. Ann Cardiothorac Surg. 2013;2(1):117-123."},{"key":"ref27","doi-asserted-by":"publisher","unstructured":"Vahanian A, Beyersdorf F, Praz F et al. 2021 ESC\/EACTS Guidelines for the management of valvular heart disease. Eur Heart J. 2022;43(7):561-632. https:\/\/doi.org\/10.1093\/eurheartj\/ehab395","DOI":"10.1093\/eurheartj\/ehab395"},{"key":"ref28","doi-asserted-by":"publisher","unstructured":"Tabrizi NS, Stout P, Richvalsky T et al. Aortic valve repair using HAART 300 geometric annuloplasty ring: a review and echocardiographic case series. J Cardiothorac Vasc Anesth. 2022;36(11):3990-3998. https:\/\/doi.org\/10.1053\/j.jvca.2022.03.013","DOI":"10.1053\/j.jvca.2022.03.013"}],"container-title":["Ugeskrift for L\u00e6ger"],"original-title":[],"deposited":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T05:59:58Z","timestamp":1747375198000},"score":1,"resource":{"primary":{"URL":"https:\/\/ugeskriftet.dk\/videnskab\/V11230740"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,30]]},"references-count":29,"URL":"https:\/\/doi.org\/10.61409\/v11230740","relation":{},"ISSN":["0041-5782","1603-6824"],"issn-type":[{"type":"print","value":"0041-5782"},{"type":"electronic","value":"1603-6824"}],"subject":[],"published":{"date-parts":[[2024,9,30]]}}}