{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T18:21:07Z","timestamp":1787163667413,"version":"build-2736575974"},"reference-count":17,"publisher":"Danish Medical Association","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ugeskr L\u00e6ger"],"abstract":"<jats:p>All pregnant women in Denmark are offered a first-trimester ultrasound screening examination between 11 and 14 weeks of gestation. Additionally, women are offered a risk assessment for foetal chromosomal abnormalities. The main results in this review are that more than 90% of pregnant women attend the first-trimester screening, and of those, 5% receive a high-risk screening result for trisomy 21. The first-trimester screening detects more than 90% of trisomy 21 cases and a large proportion of severe structural malformations. The Danish Fetal Medicine Database (DFMD) was established in 2008-2010. DFMD is a national clinical research and quality database.<\/jats:p>","DOI":"10.61409\/v12240874","type":"journal-article","created":{"date-parts":[[2025,5,9]],"date-time":"2025-05-09T02:28:54Z","timestamp":1746757734000},"page":"1-10","source":"Crossref","is-referenced-by-count":3,"title":["Combined first trimester screening in Denmark and the Danish Fetal Medicine Database"],"prefix":"10.61409","author":[{"given":"Kasper","family":"Gadsb\u00f8ll","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Sundberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ida","family":"Kirkegaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Farlie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lene","family":"Sperling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars Henning","family":"Pedersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olav Bj\u00f8rn","family":"Petersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Finn Stener","family":"J\u00f8rgensen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"40208","published-online":{"date-parts":[[2025,4,28]]},"reference":[{"key":"ref0","unstructured":"Sundhedsstyrelsen. 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Pr\u00e6natal kromosom mikroarray analyse (CMA), 2018. https:\/\/static1.squarespace.com\/static\/5d8120d60fe9717b4299a867\/t\/5dd453e717a6ae540f885a77\/1574196207797\/kromosom_mikro_array-2018-Final-rundsendt_090118.pdf (3. feb 2025)"},{"key":"ref4","unstructured":"Petersen OB, Ekelund C, Tabor A, Sundberg K. F\u00d8TO-Sandbjerg guideline 2018: 1. trimester skanning inkl. nakkefoldskanning og risikovurdering for kromosomsygdom, 2018. https:\/\/static1.squarespace.com\/static\/5d8120d60fe9717b4299a867\/t\/5f6359e284a42938957efab6\/1600346636975\/1_trim_ny-rundsendt-150118-justeret+16-09-2020.pdf (3. feb 2025)"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"Srebniak MI, Joosten M, Knapen MFCM et al. Frequency of submicroscopic chromosomal aberrations in pregnancies without increased risk for structural chromosomal aberrations: systematic review and meta-analysis. Ultrasound Obstet Gynecol. 2018;51:445-52. https:\/\/doi.org\/10.1002\/uog.17533","DOI":"10.1002\/uog.17533"},{"key":"ref6","unstructured":"Jensen TD, Gj\u00f8rup V, Kirkegaard IS et al. Gennemskanning af fosteret for misdannelser, 2009. https:\/\/static1.squarespace.com\/static\/5d8120d60fe9717b4299a867\/t\/5dd57d655828035255a60bf3\/1574272361493\/gennemscanningaffostret.pdf (3. feb 2025)"},{"key":"ref7","unstructured":"Balslev-Harder M, Becher N, Hjortsh\u00f8j TD et al. DFMS arbejdsgruppe\/guideline: Anvendelse af exom-sekventering (WES) og helgenom-sekventering (WGS) i pr\u00e6natal diagnostik, 2024. https:\/\/static1.squarespace.com\/static\/5d8120d60fe9717b4299a867\/t\/6617b4caa6ab060ec3295984\/1712829643867\/DFMS_WGS_2024_final-clean240331.pdf (3. feb 2025)"},{"key":"ref8","unstructured":"Dansk F\u00f8talmedicinsk Selskab. F\u00d8TOdatabasen. https:\/\/www.dfms.dk\/new-page-33 (3. feb 2025)"},{"key":"ref9","unstructured":"Dansk Cytogenetisk Centralregister. 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Ultrasound Obstet Gynecol. 2016;47(1):38-44. https:\/\/doi.org\/10.1002\/uog.15820","DOI":"10.1002\/uog.15820"},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"Ekelund CK, Petersen OB, J\u00f8rgensen FS et al. The Danish Fetal Medicine Database: establishment, organization and quality assessment of the first trimester screening program for trisomy 21 in Denmark 2008-2012. Acta Obstet Gynecol Scand. 2015;94(6):577-83. https:\/\/doi.org\/10.1111\/aogs.12581","DOI":"10.1111\/aogs.12581"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"Helmb\u00e6k ME, Sundberg K, J\u00f8rgensen DS et al. Clinical implementation of first trimester screening for congenital heart defects. Prenat Diagn. 2024;44(6-7):688-697. https:\/\/doi.org\/10.1002\/pd.6584","DOI":"10.1002\/pd.6584"},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"Riishede I, Rode L, Sperling L et al. Pre-eclampsia screening in Denmark (PRESIDE): national validation study. 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