{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T08:48:10Z","timestamp":1782290890626,"version":"3.54.5"},"reference-count":0,"publisher":"Danish Medical Association","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ugeskr L\u00e6ger"],"abstract":"<jats:p>Multiple symmetric lipomatosis, or Madelung\u2019s disease, is a rare condition with symmetrical fat deposits on the upper body, increasingly associated with genetic mutations. In this case report, we present a patient with an mitofusin 2 mutation causing mitochondrial dysfunction and extremely low leptin. Treatment with metreleptin led to reduced appetite, 17% weight loss, improved triglyceride levels, insulin sensitivity, and reduced liver fat. This is the first published Danish case; metreleptin shows promising results in the treatment of rare leptin-deficient lipodystrophic disorders.<\/jats:p>","DOI":"10.61409\/v12251037","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T08:11:15Z","timestamp":1782288675000},"page":"1-4","source":"Crossref","is-referenced-by-count":0,"title":["Leptin treatment of multiple symmetric lipomatosis due to a mitochondrial defect"],"prefix":"10.61409","author":[{"given":"Sigrid B.","family":"Gribsholt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens M.","family":"Bruun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steen B.","family":"Pedersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f8rn","family":"Richelsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"40208","published-online":{"date-parts":[[2026,4,27]]},"container-title":["Ugeskrift for L\u00e6ger"],"original-title":[],"deposited":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T08:11:16Z","timestamp":1782288676000},"score":1,"resource":{"primary":{"URL":"https:\/\/ugeskriftet.dk\/videnskab\/V12251037"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,27]]},"references-count":0,"URL":"https:\/\/doi.org\/10.61409\/v12251037","relation":{},"ISSN":["0041-5782","1603-6824"],"issn-type":[{"value":"0041-5782","type":"print"},{"value":"1603-6824","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,27]]}}}