{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T07:16:09Z","timestamp":1788333369393,"version":"build-2803163510"},"reference-count":30,"publisher":"Danish Medical Association","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ugeskr L\u00e6ger"],"abstract":"<jats:p>Clinical experience suggests that the use of the fetal amniotic membrane offers a promising alternative for burn wound coverage. Amnion is reported to hold advantages such as pain relief, accelerated wound healing, fewer dressing changes, and ease of use. It generally performs well on second-degree burns. Furthermore, it is considered a safe, simple, and efficient option for burn wound coverage. Overall, amnion shows excellent potential for improving burn wound care in the future; however, the evidence needs to be strengthened by further clinical trials, as argued in this review.<\/jats:p>","DOI":"10.61409\/v12251060","type":"journal-article","created":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T08:32:06Z","timestamp":1788165126000},"page":"1-9","source":"Crossref","is-referenced-by-count":0,"title":["V74022"],"prefix":"10.61409","author":[{"given":"Maja Elise","family":"Ravnberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer Berg","family":"Drej\u00f8e","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rikke","family":"Holmgaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"40208","published-online":{"date-parts":[[2026,8,31]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"ISBI Practice Guidelines for Burn Care. Burns. 2016;42(5):953-1021. https:\/\/doi.org\/10.1016\/j.burns.2016.05.013","DOI":"10.1016\/j.burns.2016.05.013"},{"key":"ref1","doi-asserted-by":"publisher","unstructured":"Ravishanker R, Bath AS, Roy R. Amnion Bank--the use of long term glycerol preserved amniotic membranes in the management of superficial and superficial partial thickness burns. Burns. 2003;29(4):369-374. https:\/\/doi.org\/10.1016\/S0305-4179(02)00304-2","DOI":"10.1016\/S0305-4179(02)00304-2"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"Ingraldi AL, Audet RG, Tabor AJ. The Preparation and Clinical Efficacy of Amnion-Derived Membranes: A Review. J Funct Biomater. 2023;14(10):531. https:\/\/doi.org\/10.3390\/jfb14100531","DOI":"10.3390\/jfb14100531"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"Davis JS. II. Skin Grafting at the Johns Hopkins Hospital. Ann Surg. 1909;50(3):542-549. https:\/\/doi.org\/10.1097\/00000658-190909000-00002","DOI":"10.1097\/00000658-190909000-00002"},{"key":"ref4","doi-asserted-by":"publisher","unstructured":"Kesting MR, Wolff KD, Hohlweg-Majert B, Steinstraesser L. The role of allogenic amniotic membrane in burn treatment. J Burn Care Res. 2008;29(6):907-916. https:\/\/doi.org\/10.1097\/BCR.0b013e31818b9e40","DOI":"10.1097\/BCR.0b013e31818b9e40"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"Munoz-Torres JR, Mart\u00ednez-Gonz\u00e1lez SB, Lozano-Luj\u00e1n AD, et al. Biological properties and surgical applications of the human amniotic membrane. Front Bioeng Biotechnol. 2023;10:1067480. https:\/\/doi.org\/10.3389\/fbioe.2022.1067480","DOI":"10.3389\/fbioe.2022.1067480"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"Hao Y, Ma DH, Hwang DG, et al. Identification of antiangiogenic and antiinflammatory proteins in human amniotic membrane. Cornea. 2000;19(3):348-352. https:\/\/doi.org\/10.1097\/00003226-200005000-00018","DOI":"10.1097\/00003226-200005000-00018"},{"key":"ref7","doi-asserted-by":"publisher","unstructured":"Mao Y, Hoffman T, Singh-Varma A, et al. Antimicrobial Peptides Secreted From Human Cryopreserved Viable Amniotic Membrane Contribute to its Antibacterial Activity. Sci Rep. 2017;7(1):13722. https:\/\/doi.org\/10.1038\/s41598-017-13310-6","DOI":"10.1038\/s41598-017-13310-6"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"Tseng SC, Li DQ, Ma X. Suppression of transforming growth factor-beta isoforms, TGF-beta receptor type II, and myofibroblast differentiation in cultured human corneal and limbal fibroblasts by amniotic membrane matrix. J Cell Physiol. 1999;179(3):325-35. https:\/\/doi.org\/10.1002\/(SICI)1097-4652(199906)179:3<325::AID-JCP10>3.0.CO;2-X","DOI":"10.1002\/(SICI)1097-4652(199906)179:3<325::AID-JCP10>3.0.CO;2-X"},{"key":"ref9","doi-asserted-by":"publisher","unstructured":"Niknejad H, Paeini-Vayghan G, Tehrani FA, et al. Side dependent effects of the human amnion on angiogenesis. Placenta. 2013;34(4):340-345. https:\/\/doi.org\/10.1016\/j.placenta.2013.02.001","DOI":"10.1016\/j.placenta.2013.02.001"},{"key":"ref10","doi-asserted-by":"publisher","unstructured":"Klama-Bary\u0142a A, \u0141abu\u015b W, Kitala D, et al. Experience in Using Fetal Membranes: The Present and New Perspectives. Transplant Proc. 2018;50(7):2188-2194. https:\/\/doi.org\/10.1016\/j.transproceed.2018.02.120","DOI":"10.1016\/j.transproceed.2018.02.120"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"Gholipourmalekabadi M, Bandehpour M, Mozafari M, et al. Decellularized human amniotic membrane: more is needed for an efficient dressing for protection of burns against antibiotic-resistant bacteria isolated from burn patients. Burns. 2015;41(7):1488-1497. https:\/\/doi.org\/10.1016\/j.burns.2015.04.015","DOI":"10.1016\/j.burns.2015.04.015"},{"key":"ref12","doi-asserted-by":"publisher","unstructured":"Gholipourmalekabadi M, Farhadihosseinabadi B, Faraji M, Nourani MR. How preparation and preservation procedures affect the properties of amniotic membrane? How safe are the procedures? Burns. 2020;46(6):1254-1271. https:\/\/doi.org\/10.1016\/j.burns.2019.07.005","DOI":"10.1016\/j.burns.2019.07.005"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"Proksch E, Jensen JM, Crichton-Smith A, et al. [Rational treatment of first-degree burns]. Hautarzt. 2007;58(7):604-610. https:\/\/doi.org\/10.1007\/s00105-007-1364-3","DOI":"10.1007\/s00105-007-1364-3"},{"key":"ref14","doi-asserted-by":"publisher","unstructured":"Abul A, Karam M, Rahman S. Human Amniotic Membrane: A New Option for Graft Donor Sites - Systematic Review and Meta-analysis. Int Wound J. 2020;17(3):547-554. https:\/\/doi.org\/10.1111\/iwj.13313","DOI":"10.1111\/iwj.13313"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"Salehi SH, As'adi K, Mousavi SJ, Shoar S. Evaluation of Amniotic Membrane Effectiveness in Skin Graft Donor Site Dressing in Burn Patients. Indian J Surg. 2015;77(suppl 2):427-431. https:\/\/doi.org\/10.1007\/s12262-013-0864-x","DOI":"10.1007\/s12262-013-0864-x"},{"key":"ref16","unstructured":"Eskandarlou M, Azimi M, Rabiee S, Seif Rabiee MA. The Healing Effect of Amniotic Membrane in Burn Patients. World J Plast Surg. 2016;5(1):39-44"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"Mohammadi A, Johari HG. Amniotic membrane: a skin graft fixator convenient for both patient and surgeon. Burns. 2008;34(7):1051-1052. https:\/\/doi.org\/10.1016\/j.burns.2008.02.004","DOI":"10.1016\/j.burns.2008.02.004"},{"key":"ref18","doi-asserted-by":"publisher","unstructured":"Mohammadi AA, Johari HG, Eskandari S. Effect of amniotic membrane on graft take in extremity burns. Burns. 2013;39(6):1137-1141. https:\/\/doi.org\/10.1016\/j.burns.2013.01.017","DOI":"10.1016\/j.burns.2013.01.017"},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"Mohammadi AA, Eskandari S, Johari HG, Rajabnejad A. Using Amniotic Membrane as a Novel Method to Reduce Post-burn Hypertrophic Scar Formation: A Prospective Follow-up Study. J Cutan Aesthet Surg. 2017;10(1):13-17. https:\/\/doi.org\/10.4103\/jcas.Jcas_109_16","DOI":"10.4103\/JCAS.JCAS_109_16"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"Sawhney CP. Amniotic membrane as a biological dressing in the management of burns. Burns. 1989;15(5):339-342. https:\/\/doi.org\/10.1016\/0305-4179(89)90015-6","DOI":"10.1016\/0305-4179(89)90015-6"},{"key":"ref21","doi-asserted-by":"publisher","unstructured":"Moghimi MH, Salehian M, Abdi M, et al. The impact of an open-label design on human amniotic membranes vs. silver sulfadiazine dressings for second-degree burns: a randomized controlled clinical trial. BMC Surg. 2024;24(1):309. https:\/\/doi.org\/10.1186\/s12893-024-02554-5","DOI":"10.1186\/s12893-024-02554-5"},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"Adly OA, Moghazy AM, Abbas AH, et al. Assessment of amniotic and polyurethane membrane dressings in the treatment of burns. Burns. 2010;36(5):703-710. https:\/\/doi.org\/10.1016\/j.burns.2009.09.003","DOI":"10.1016\/j.burns.2009.09.003"},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"Branski LK, Herndon DN, Celis MM, et al. Amnion in the treatment of pediatric partial-thickness facial burns. Burns. 2008;34(3):393-399. https:\/\/doi.org\/10.1016\/j.burns.2007.06.007","DOI":"10.1016\/j.burns.2007.06.007"},{"key":"ref24","doi-asserted-by":"publisher","unstructured":"Mostaque AK, Rahman KBMA. Comparisons of the effects of biological membrane (amnion) and silver sulfadiazine in the management of burn wounds in children. J Burn Care Res. 2011;32(2):200-209. https:\/\/doi.org\/10.1097\/BCR.0b013e31820aad94","DOI":"10.1097\/BCR.0b013e31820aad94"},{"key":"ref25","doi-asserted-by":"publisher","unstructured":"Bujang-Safawi E, Halim AS, Khoo TL, Dorai AA. Dried irradiated human amniotic membrane as a biological dressing for facial burns--a 7-year case series. Burns. 2010;36(6):876-882. https:\/\/doi.org\/10.1016\/j.burns.2009.07.001","DOI":"10.1016\/j.burns.2009.07.001"},{"key":"ref26","unstructured":"Andonovska D, Dzokic G, Spasevska L, et al. The advantages of the application of amnion membrane in the treatment of burns. Prilozi. 2008;29(1):183-198."},{"key":"ref27","doi-asserted-by":"publisher","unstructured":"Gajiwala K, Gajiwala AL. Evaluation of lyophilised, gamma-irradiated amnion as a biological dressing. Cell Tissue Bank. 2004;5(2):73-80. https:\/\/doi.org\/10.1023\/B:CATB.0000034076.16744.4b","DOI":"10.1023\/B:CATB.0000034076.16744.4b"},{"key":"ref28","doi-asserted-by":"publisher","unstructured":"Yang C, Xiong AB, He XC, et al. Efficacy and feasibility of amniotic membrane for the treatment of burn wounds: A meta-analysis. J Trauma Acute Care Surg. 2021;90(4):744-755. https:\/\/doi.org\/10.1097\/TA.0000000000003050","DOI":"10.1097\/TA.0000000000003050"},{"key":"ref29","unstructured":"Ley-Ch\u00e1vez E, Mart\u00ednez-Pardo ME, Roman R, et al. Application of biological dressings from radiosterilized amnios with cobalt 60 and serologic studies on the handling of burns in pediatric patients. Ann Transplant. 2003;8(4):46-49."}],"container-title":["Ugeskrift for L\u00e6ger"],"original-title":[],"deposited":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T06:52:42Z","timestamp":1788331962000},"score":1,"resource":{"primary":{"URL":"https:\/\/ugeskriftet.dk\/videnskab\/V12251060"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,31]]},"references-count":30,"URL":"https:\/\/doi.org\/10.61409\/v12251060","relation":{},"ISSN":["0041-5782","1603-6824"],"issn-type":[{"value":"0041-5782","type":"print"},{"value":"1603-6824","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,31]]}}}