{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T07:20:37Z","timestamp":1784704837296,"version":"3.55.0"},"reference-count":23,"publisher":"Federa\u00e7\u00e3o das Associa\u00e7\u00f5es de Ginecologia e Obstetr\u00edcia","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,26]]},"DOI":"10.61622\/rbgo\/2024rbgo62","type":"journal-article","created":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T19:34:18Z","timestamp":1722454458000},"source":"Crossref","is-referenced-by-count":1,"title":["Study of 138 vulvar lichen sclerosus patients and the malignant risk transformation"],"prefix":"10.61622","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2435-831X","authenticated-orcid":false,"given":"Bruna Obeica","family":"Vasconcellos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4212-0022","authenticated-orcid":false,"given":"Susana Cristina Aid\u00e9 Viviani","family":"Fialho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9885-2724","authenticated-orcid":false,"given":"Isabel Cristina Chulvis do Val","family":"Guimar\u00e3es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7207-7969","authenticated-orcid":false,"given":"Caroline Alves de Oliveira","family":"Martins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4814-5076","authenticated-orcid":false,"given":"Jos\u00e9 Rodrigo de","family":"Moraes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9210-2925","authenticated-orcid":false,"given":"Rita Maira","family":"Zanine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6252-338X","authenticated-orcid":false,"given":"Julia Correa Cardoso","family":"Guimar\u00e3es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2801-416X","authenticated-orcid":false,"given":"Faustino","family":"P\u00e9rez-L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"47794","reference":[{"issue":"4","key":"key20240731134443_B1","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1080\/13697137.2017.1343295","article-title":"Lichen sclerosus in women: a review","volume":"20","author":"P\u00e9rez-L\u00f3pez","year":"2017","unstructured":"1. P\u00e9rez-L\u00f3pez FR, Vieira-Baptista P. Lichen sclerosus in women: a review. Climacteric. 2017;20(4):339-47. doi: 10.1080\/13697137.2017.1343295","journal-title":"Climacteric"},{"issue":"2","key":"key20240731134443_B2","doi-asserted-by":"crossref","first-page":"238","DOI":"10.2340\/00015555-1512","article-title":"Association of autoimmune diseases with lichen sclerosus in 532 male and female patients","volume":"93","author":"Kreuter","year":"2013","unstructured":"2. Kreuter A, Kryvosheyeva Y, Terras S, Moritz R, M\u00f6llenhoff K, Altmeyer P, et al. Association of autoimmune diseases with lichen sclerosus in 532 male and female patients. Acta Derm Venereol. 2013;93(2):238-41. doi: 10.2340\/00015555-1512","journal-title":"Acta Derm Venereol"},{"issue":"1","key":"key20240731134443_B3","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1097\/LGT.0000000000000572","article-title":"Diagnostic criteria for differentiated vulvar intraepithelial neoplasia and vulvar aberrant maturation","volume":"25","author":"Heller","year":"2021","unstructured":"3. Heller DS, Day T, Allbritton JI, Scurry J, Radici G, Welch K, et al. Diagnostic criteria for differentiated vulvar intraepithelial neoplasia and vulvar aberrant maturation. J Low Genit Tract Dis. 2021;25(1):57-70. doi: 10.1097\/LGT.0000000000000572","journal-title":"J Low Genit Tract Dis"},{"issue":"7","key":"key20240731134443_B4","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1111\/1471-0528.16175","article-title":"Incidence of lichen sclerosus and subsequent causes of death: a nationwide Finnish register study","volume":"127","author":"Halonen","year":"2020","unstructured":"4. Halonen P, Jakobsson M, Heikinheimo O, Gissler M, Pukkala E. Incidence of lichen sclerosus and subsequent causes of death: a nationwide Finnish register study. BJOG. 2020;127(7):814-9. doi: 10.1111\/1471-0528.16175","journal-title":"BJOG"},{"issue":"4","key":"key20240731134443_B5","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1097\/01.grf.0000179635.64663.3d","article-title":"An overview of lichen sclerosus","volume":"48","author":"Val","year":"2005","unstructured":"5. Val I, Almeida G. An overview of lichen sclerosus. Clin Obstet Gynecol. 2005;48(4):808-17. doi: 10.1097\/01.GRF.0000179635.64663.3D","journal-title":"Clin Obstet Gynecol"},{"key":"key20240731134443_B6","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.ejcb.2004.12.003","article-title":"Immune dysregulation in lichen sclerosus","volume":"84","author":"Regauer","year":"2005","unstructured":"6. Regauer S. Immune dysregulation in lichen sclerosus. Eur J Cell Biol. 2005;84(2-3):273-7. doi: 10.1016\/J.EJCB.2004.12.003","journal-title":"Eur J Cell Biol"},{"issue":"6","key":"key20240731134443_B7","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1007\/s00428-018-2436-8","article-title":"Differentiated vulvar intraepithelial neoplasia (dVIN): the most helpful histological features and the utility of cytokeratins 13 and 17","volume":"473","author":"Dasgupta","year":"2018","unstructured":"7. Dasgupta S, Ewing-Graham PC, van Kemenade FJ, van Doorn HC, Noordhoek Hegt V, Koljenovic S. Differentiated vulvar intraepithelial neoplasia (dVIN): the most helpful histological features and the utility of cytokeratins 13 and 17. Virchows Arch. 2018;473(6):739-47. doi: 10.1007\/S00428-018-2436-8","journal-title":"Virchows Arch"},{"issue":"2","key":"key20240731134443_B8","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1097\/AOG.0000000000002460","article-title":"Diagnosis and treatment of vulvar dermatoses","volume":"131","author":"Stockdale","year":"2018","unstructured":"8. Stockdale CK, Boardman L. Diagnosis and treatment of vulvar dermatoses. Obstet Gynecol. 2018;131(2):371-86. doi: 10.1097\/AOG.0000000000002460","journal-title":"Obstet Gynecol"},{"issue":"012017","key":"key20240731134443_B9","article-title":"Trends and usage pattern of SPSS and Minitab Software in Scientific research","volume":"1734","author":"Okagbue","year":"2021","unstructured":"9. Okagbue HI, Oguntunde PE, Obasi EC, Akhmetshin EM. Trends and usage pattern of SPSS and Minitab Software in Scientific research. J Phys Conf Ser. 2021;1734(012017). doi: 10.1088\/1742-6596\/1734\/1\/012017","journal-title":"J Phys Conf Ser"},{"issue":"8","key":"key20240731134443_B10","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1158\/1055-9965.EPI-16-0019","article-title":"Lichen sclerosus: incidence and risk of vulvar squamous cell carcinoma","volume":"25","author":"Bleeker","year":"2016","unstructured":"10. Bleeker MC, Visser PJ, Overbeek LI, van Beurden M, Berkhof J. Lichen sclerosus: incidence and risk of vulvar squamous cell carcinoma. Cancer Epidemiol Biomarkers Prev. 2016;25(8):1224-30. doi: 10.1158\/1055-9965.EPI-16-0019","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"5","key":"key20240731134443_B11","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1007\/s40257-018-0364-7","article-title":"Diagnosis and treatment of vulvar lichen sclerosus: an update for dermatologists","volume":"19","author":"Lee","year":"2018","unstructured":"11. Lee A, Fischer G. Diagnosis and treatment of vulvar lichen sclerosus: an update for dermatologists. Am J Clin Dermatol. 2018;19(5):695-706. doi: 10.1007\/s40257-018-0364-7","journal-title":"Am J Clin Dermatol"},{"issue":"9166","key":"key20240731134443_B12","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1016\/S0140-6736(98)08228-2","article-title":"Lichen sclerosus","volume":"353","author":"Powell","year":"1999","unstructured":"12. Powell JJ, Wojnarowska F. Lichen sclerosus. Lancet. 1999;353(9166):1777-83. doi: 10.1016\/s0140-6736(98)08228-2","journal-title":"Lancet"},{"issue":"6","key":"key20240731134443_B13","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1001\/archderm.140.6.702","article-title":"Does treatment of vulvar lichen sclerosus influence its prognosis?","volume":"140","author":"Cooper","year":"2004","unstructured":"13. Cooper SM, Gao XH, Powell JJ, Wojnarowska F. Does treatment of vulvar lichen sclerosus influence its prognosis? Arch Dermatol. 2004;140(6):702-6. doi: 10.1001\/archderm.140.6.702","journal-title":"Arch Dermatol"},{"issue":"10","key":"key20240731134443_B14","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1001\/jamadermatol.2015.0643","article-title":"Long-term management of adult vulvar lichen sclerosus: a prospective cohort study of 507 women","volume":"151","author":"Lee","year":"2015","unstructured":"14. Lee A, Bradford J, Fischer G. Long-term management of adult vulvar lichen sclerosus: a prospective cohort study of 507 women. JAMA Dermatol. 2015;151(10):1061-7. doi: 10.1001\/jamadermatol.2015.0643","journal-title":"JAMA Dermatol"},{"issue":"3","key":"key20240731134443_B15","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/j.ygyno.2020.02.020","article-title":"The risk of developing squamous cell carcinoma in patients with anogenital lichen sclerosis: a systematic review","volume":"157","author":"Spekreijse","year":"2020","unstructured":"15. Spekreijse JJ, Streng BM, Vermeulen RF, Voss FO, Vermaat H, van Beurden M. The risk of developing squamous cell carcinoma in patients with anogenital lichen sclerosis: a systematic review. Gynecol Oncol. 2020;157(3):671-7. doi: 10.1016\/j.ygyno.2020.02.020","journal-title":"Gynecol Oncol"},{"issue":"6","key":"key20240731134443_B16","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1111\/1471-0528.14560","article-title":"Current insights into the aetiology, pathobiology, and management of local disease recurrence in squamous cell carcinoma of the vulva","volume":"124","author":"Yap","year":"2017","unstructured":"16. Yap J, O'Neill D, Nagenthiran S, Dawson CW, Luesley DM. Current insights into the aetiology, pathobiology, and management of local disease recurrence in squamous cell carcinoma of the vulva. BJOG. 2017;124(6):946-54. doi: 10.1111\/1471-0528.14560","journal-title":"BJOG"},{"issue":"2","key":"key20240731134443_B17","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.jogc.2021.09.023","article-title":"Risk of Vulvar squamous cell carcinoma in lichen sclerosus and lichen planus: a systematic review","volume":"44","author":"Leis","year":"2022","unstructured":"17. Leis M, Singh A, Li C, Ahluwalia R, Fleming P, Lynde CW. Risk of Vulvar squamous cell carcinoma in lichen sclerosus and lichen planus: a systematic review. J Obstet Gynaecol Can. 2022;44(2):182-92. doi: 10.1016\/j.jogc.2021.09.023","journal-title":"J Obstet Gynaecol Can"},{"issue":"2","key":"key20240731134443_B18","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1097\/LGT.0000000000000186","article-title":"Vulvar lichen sclerosus and neoplastic transformation: a retrospective study of 976 cases","volume":"20","author":"Micheletti","year":"2016","unstructured":"18. Micheletti L, Preti M, Radici G, Boveri S, Di Pumpo O, Privitera SS, et al. Vulvar lichen sclerosus and neoplastic transformation: a retrospective study of 976 cases. J Low Genit Tract Dis. 2016;20(2):180-3. doi: 10.1097\/LGT.0000000000000186","journal-title":"J Low Genit Tract Dis"},{"issue":"5","key":"key20240731134443_B19","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1111\/j.1365-2133.1991.tb00626.x","article-title":"The treatment of vulval lichen sclerosus with a very potent topical steroid (clobetasol propionate 0.05%) cream","volume":"124","author":"Dalziel","year":"1991","unstructured":"19. Dalziel KL, Millard PR, Wojnarowska F. The treatment of vulval lichen sclerosus with a very potent topical steroid (clobetasol propionate 0.05%) cream. Br J Dermatol. 1991;124(5):461-4. doi: 10.1111\/j.1365-2133.1991.tb00626.x","journal-title":"Br J Dermatol"},{"issue":"2","key":"key20240731134443_B20","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.jaad.2012.02.044","article-title":"Systematic review and meta-analysis of randomized controlled trials on topical interventions for genital lichen sclerosus","volume":"67","author":"Chi","year":"2012","unstructured":"20. Chi CC, Kirtschig G, Baldo M, Lewis F, Wang SH, Wojnarowska F. Systematic review and meta-analysis of randomized controlled trials on topical interventions for genital lichen sclerosus. J Am Acad Dermatol. 2012;67(2):305-12. doi: 10.1016\/j.jaad.2012.02.044","journal-title":"J Am Acad Dermatol"},{"issue":"3","key":"key20240731134443_B21","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1097\/LGT.0000000000000673","article-title":"Risk of development of vulvar cancer in women with lichen sclerosus or lichen planus: a systematic review","volume":"26","author":"Vieira-Baptista","year":"2022","unstructured":"21. Vieira-Baptista P, P\u00e9rez-L\u00f3pez FR, L\u00f3pez-Baena MT, Stockdale CK, Preti M, Bornstein J. Risk of development of vulvar cancer in women with lichen sclerosus or lichen planus: a systematic review. J Low Genit Tract Dis. 2022;26(3):250-7. doi: 10.1097\/LGT.0000000000000673","journal-title":"J Low Genit Tract Dis"},{"key":"key20240731134443_B22","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/7480754","article-title":"Etiology, clinical features, and diagnosis of vulvar lichen sclerosus: a scoping review","volume":"2020","author":"Singh","year":"2020","unstructured":"22. Singh N, Ghatage P. Etiology, clinical features, and diagnosis of vulvar lichen sclerosus: a scoping review. Obstet Gynecol Int. 2020;2020:7480754. doi: 10.1155\/2020\/7480754","journal-title":"Obstet Gynecol Int"},{"issue":"12","key":"key20240731134443_B23","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1111\/j.1471-0528.1990.tb02502.x","article-title":"The epithelial changes associated with squamous cell carcinoma of the vulva: a review of the clinical, histological and viral findings in 78 women","volume":"97","author":"Leibowitch","year":"1990","unstructured":"23. Leibowitch M, Neill S, Pelisse M, Moyal-Baracco M. The epithelial changes associated with squamous cell carcinoma of the vulva: a review of the clinical, histological and viral findings in 78 women. Br J Obstet Gynaecol. 1990;97(12):1135-9. doi: 10.1111\/j.1471-0528.1990.tb02502.x","journal-title":"Br J Obstet Gynaecol"}],"container-title":["Revista Brasileira de Ginecologia e Obstetr\u00edcia"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journalrbgo.org\/wp-content\/uploads\/sites\/4\/articles_xml\/1806-9339-rbgo-46-e-rbgo62\/1806-9339-rbgo-46-e-rbgo62.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T16:52:53Z","timestamp":1724345573000},"score":1,"resource":{"primary":{"URL":"https:\/\/journalrbgo.org\/article\/study-of-138-vulvar-lichen-sclerosus-patients-and-the-malignant-risk-transformation\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":23,"alternative-id":["10.61622\/rbgo\/2024rbgo62"],"URL":"https:\/\/doi.org\/10.61622\/rbgo\/2024rbgo62","relation":{},"ISSN":["0100-7203","1806-9339"],"issn-type":[{"value":"0100-7203","type":"print"},{"value":"1806-9339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]},"article-number":"e-rbgo62"}}