{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T14:32:27Z","timestamp":1754145147775,"version":"3.41.2"},"reference-count":26,"publisher":"Federa\u00e7\u00e3o das Associa\u00e7\u00f5es de Ginecologia e Obstetr\u00edcia","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,7,15]]},"DOI":"10.61622\/rbgo\/2025rbgo43","type":"journal-article","created":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T15:51:10Z","timestamp":1752681070000},"source":"Crossref","is-referenced-by-count":0,"title":["Leptin receptor polymorphism increases the risk of painful symptoms in Brazilian women with endometriosis"],"prefix":"10.61622","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6758-3664","authenticated-orcid":false,"given":"J\u00e9ssica Vilarinho","family":"Cardoso","sequence":"first","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2640-8579","authenticated-orcid":false,"given":"Daniel Escorsim","family":"Machado","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6075-6078","authenticated-orcid":false,"given":"Fernanda Nunes de","family":"Almeida","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4426-699X","authenticated-orcid":false,"given":"Pl\u00ednio Tostes","family":"Berardo","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3010-8373","authenticated-orcid":false,"given":"Rui","family":"Medeiros","sequence":"additional","affiliation":[]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7683-0698","authenticated-orcid":false,"given":"Jamila Alessandra","family":"Perini","sequence":"additional","affiliation":[]}],"member":"47794","reference":[{"issue":"9","key":"key20250716155106_B1","article-title":"Endometriosis: a review of clinical diagnosis, treatment, and pathogenesis","volume":"14","author":"Chauhan","year":"2022","unstructured":"Chauhan S, More A, Chauhan V, Kathane A. Endometriosis: a review of clinical diagnosis, treatment, and pathogenesis. Cureus. 2022;14(9):e28864. doi: 10.7759\/cureus.28864","journal-title":"Cureus"},{"key":"key20250716155106_B2","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/s13048-015-0180-0","article-title":"Leptin, its receptor and aromatase expression in deep infiltrating endometriosis","volume":"8","author":"Gon\u00e7alves","year":"2015","unstructured":"Gon\u00e7alves HF, Zendron C, Cavalcante FS, Aiceles V, Oliveira MA, Manaia JH, et al. Leptin, its receptor and aromatase expression in deep infiltrating endometriosis. J Ovarian Res. 2015;8:53. doi: 10.1186\/s13048-015-0180-0","journal-title":"J Ovarian Res"},{"key":"key20250716155106_B3","doi-asserted-by":"crossref","first-page":"6290693","DOI":"10.1155\/2020\/6290693","article-title":"Serum leptin as a marker for severity of endometriosis","volume":"2020","author":"Hussein","year":"2020","unstructured":"Hussein SS, Farhan FS, Ibrahim Ali A. Serum leptin as a marker for severity of endometriosis. Obstet Gynecol Int. 2020;2020:6290693. doi: 10.1155\/2020\/6290693","journal-title":"Obstet Gynecol Int"},{"issue":"9","key":"key20250716155106_B4","first-page":"9753","article-title":"Effect of interactions between LEPR polymorphisms and smoking on coronary artery disease susceptibility","volume":"10","author":"Shi","year":"2017","unstructured":"Shi R, Zhang M, Wang W, Song X, Liu H, Tian R, et al. Effect of interactions between LEPR polymorphisms and smoking on coronary artery disease susceptibility. Int J Clin Exp Pathol. 2017;10(9):9753-9.","journal-title":"Int J Clin Exp Pathol"},{"issue":"9","key":"key20250716155106_B5","doi-asserted-by":"crossref","first-page":"15145","DOI":"10.1002\/jcb.28776","article-title":"Leptin \u22122548 G\/A polymorphisms are associated to clinical progression of oral cancer and sensitive to oral tumorization in nonsmoking population","volume":"120","author":"Hung","year":"2019","unstructured":"Hung W, Tsai C, Lin C, Chuang C, Yang S, Weng C. Leptin \u22122548 G\/A polymorphisms are associated to clinical progression of oral cancer and sensitive to oral tumorization in nonsmoking population. J Cell Biochem. 2019;120(9):15145-56. doi: 10.1002\/jcb.28776","journal-title":"J Cell Biochem"},{"key":"key20250716155106_B6","doi-asserted-by":"crossref","first-page":"104616","DOI":"10.1016\/j.yexmp.2021.104616","article-title":"DROSHA rs10719 and DICER1 rs3742330 polymorphisms in endometriosis and different diseases: case-control and review studies","volume":"119","author":"Cardoso","year":"2021","unstructured":"Cardoso JV, Medeiros R, Dias F, Costa IA, Ferrari R, Berardo PT, et al. DROSHA rs10719 and DICER1 rs3742330 polymorphisms in endometriosis and different diseases: case-control and review studies. Exp Mol Pathol. 2021;119:104616. doi: 10.1016\/j.yexmp.2021.104616","journal-title":"Exp Mol Pathol"},{"issue":"3","key":"key20250716155106_B7","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1055\/s-0039-1679879","article-title":"Variables associated with endometriosis-related pain: a pilot study using a visual analogue scale","volume":"41","author":"Cozzolino","year":"2019","unstructured":"Cozzolino M, Coccia ME, Lazzeri G, Basile F, Troiano G. Variables associated with endometriosis-related pain: a pilot study using a visual analogue scale. Rev Bras Ginecol Obstet. 2019;41(3):170-5. doi: 10.1055\/s-0039-1679879","journal-title":"Rev Bras Ginecol Obstet"},{"issue":"5","key":"key20250716155106_B8","doi-asserted-by":"crossref","first-page":"1999","DOI":"10.1007\/s00394-019-02049-7","article-title":"Leptin gene polymorphism (rs7799039; G2548A) is associated with changes in serum lipid concentrations during pregnancy: a prospective cohort study","volume":"59","author":"Farias","year":"2020","unstructured":"Farias DR, Alves-Santos NH, Eshriqui I, Martins MC, Struchiner CJ, Lepsch J, et al. Leptin gene polymorphism (rs7799039; G2548A) is associated with changes in serum lipid concentrations during pregnancy: a prospective cohort study. Eur J Nutr. 2020;59(5):1999-2009. doi: 10.1007\/s00394-019-02049-7","journal-title":"Eur J Nutr"},{"issue":"1","key":"key20250716155106_B9","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s12974-020-01752-1","article-title":"Autonomic nervous system and inflammation interaction in endometriosis-associated pain","volume":"17","author":"Wei","year":"2020","unstructured":"Wei Y, Liang Y, Lin H, Dai Y, Yao S. Autonomic nervous system and inflammation interaction in endometriosis-associated pain. J Neuroinflammation. 2020;17(1):80. doi: 10.1186\/s12974-020-01752-1","journal-title":"J Neuroinflammation"},{"issue":"4","key":"key20250716155106_B10","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1189\/jlb.68.4.437","article-title":"Leptin in the regulation of immunity, inflammation, and hematopoiesis","volume":"68","author":"Fantuzzi","year":"2000","unstructured":"Fantuzzi G, Faggioni R. Leptin in the regulation of immunity, inflammation, and hematopoiesis. J Leukoc Biol. 2000;68(4):437-46. doi: 10.1189\/jlb.68.4.437","journal-title":"J Leukoc Biol"},{"issue":"6","key":"key20250716155106_B11","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.3390\/cells10061381","article-title":"Pathogenesis of endometriosis: the origin of pain and subfertility","volume":"10","author":"Gruber","year":"2021","unstructured":"Gruber TM, Mechsner S. Pathogenesis of endometriosis: the origin of pain and subfertility. Cells. 2021;10(6):1381. doi: 10.3390\/cells10061381","journal-title":"Cells"},{"issue":"3","key":"key20250716155106_B12","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1093\/humrep\/dei376","article-title":"Peritoneal fluid leptin is associated with chronic pelvic pain but not infertility in endometriosis patients","volume":"21","author":"Bedaiwy","year":"2006","unstructured":"Bedaiwy MA, Falcone T, Goldberg JM, Sharma RK, Nelson DR, Agarwal A. Peritoneal fluid leptin is associated with chronic pelvic pain but not infertility in endometriosis patients. Hum Reprod. 2006;21(3):788-91. doi: 10.1093\/humrep\/dei376","journal-title":"Hum Reprod"},{"issue":"2","key":"key20250716155106_B13","doi-asserted-by":"crossref","first-page":"173","DOI":"10.30699\/ijp.2023.1972584.3017","article-title":"The relationship between leptin receptor expression and endometrial carcinoma; A case-control study","volume":"18","author":"Sehhat","year":"2023","unstructured":"Sehhat M, Moshfegh Arani Z, Lajevardi Hosseini N, Reiesifar M, Abdi Abyaneh F, Vakili Z. The relationship between leptin receptor expression and endometrial carcinoma; A case-control study. Iran J Pathol. 2023;18(2):173-9. doi: 10.30699\/ijp.2023.1972584.3017","journal-title":"Iran J Pathol"},{"key":"key20250716155106_B14","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.archoralbio.2019.05.014","article-title":"Interactions among moderate\/severe periodontitis, ADIPOQ-rs1501299, and LEPR-rs1137100 polymorphisms on the risk of type 2 diabetes in a Chinese population","volume":"103","author":"Cao","year":"2019","unstructured":"Cao X, Huo P, Li W, Li P, He L, Meng H. Interactions among moderate\/severe periodontitis, ADIPOQ-rs1501299, and LEPR-rs1137100 polymorphisms on the risk of type 2 diabetes in a Chinese population. Arch Oral Biol. 2019;103:26-32. doi: 10.1016\/j.archoralbio.2019.05.014","journal-title":"Arch Oral Biol"},{"issue":"4","key":"key20250716155106_B15","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1007\/s10517-022-05408-3","article-title":"The effect of polymorphisms of energy metabolism genes on metabolic disorders in overweight adolescents of two ethnicities","volume":"172","author":"Ievleva","year":"2022","unstructured":"Ievleva KD, Bairova TA, Sheneman EA, Ayurova ZG, Balzhieva VV, Novikova EA, et al. The effect of polymorphisms of energy metabolism genes on metabolic disorders in overweight adolescents of two ethnicities. Bull Exp Biol Med. 2022;172(4):430-4. doi: 10.1007\/s10517-022-05408-3","journal-title":"Bull Exp Biol Med"},{"issue":"6","key":"key20250716155106_B16","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1097\/JCMA.0000000000000918","article-title":"Correlation of Q223R and K109R polymorphisms in leptin receptor gene with susceptibility of breast cancer: a systematic review and meta-analysis","volume":"86","author":"Zhu","year":"2023","unstructured":"Zhu S, Tang Z, Tang Y, Tan T, Chen B, Xie D, et al. Correlation of Q223R and K109R polymorphisms in leptin receptor gene with susceptibility of breast cancer: a systematic review and meta-analysis. J Chin Med Assoc. 2023;86(6):549-56. doi: 10.1097\/JCMA.0000000000000918","journal-title":"J Chin Med Assoc"},{"issue":"9","key":"key20250716155106_B17","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.1093\/hmg\/ddq056","article-title":"Genome-wide association study identifies polymorphisms in LEPR as determinants of plasma soluble leptin receptor levels","volume":"19","author":"Sun","year":"2010","unstructured":"Sun Q, Cornelis MC, Kraft P, Qi L, van Dam RM, Girman CJ, et al. Genome-wide association study identifies polymorphisms in LEPR as determinants of plasma soluble leptin receptor levels. Hum Mol Genet. 2010;19(9):1846-55. doi: 10.1093\/hmg\/ddq056","journal-title":"Hum Mol Genet"},{"issue":"7","key":"key20250716155106_B18","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1055\/s-2002-33466","article-title":"A polymorphism in the leptin promoter region (-2548 G\/A) influences gene expression and adipose tissue secretion of leptin","volume":"34","author":"Hoffstedt","year":"2002","unstructured":"Hoffstedt J, Eriksson P, Mottagui-Tabar S, Arner P. A polymorphism in the leptin promoter region (-2548 G\/A) influences gene expression and adipose tissue secretion of leptin. Horm Metab Res. 2002;34(7):355-9. doi: 10.1055\/s-2002-33466","journal-title":"Horm Metab Res"},{"issue":"1","key":"key20250716155106_B19","doi-asserted-by":"crossref","first-page":"84","DOI":"10.14715\/cmb\/2018.64.1.15","article-title":"Correlation between serum leptin and its gene expression to the anthropometric measures in overweight and obese children","volume":"64","author":"Eldosouky","year":"2018","unstructured":"Eldosouky MK, Abdu Allah AM, AbdElmoneim A, Al-Ahmadi NS. Correlation between serum leptin and its gene expression to the anthropometric measures in overweight and obese children. Cell Mol Biol (Noisy-le-grand). 2018;64(1):84-90. doi: 10.14715\/cmb\/2018.64.1.15","journal-title":"Cell Mol Biol (Noisy-le-grand)"},{"issue":"5","key":"key20250716155106_B20","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1002\/ijc.24372","article-title":"Functional analysis of the \u22122548G\/A leptin gene polymorphism in breast cancer cells","volume":"125","author":"Terrasi","year":"2009","unstructured":"Terrasi M, Fiorio E, Mercanti A, Koda M, Moncada CA, Sulkowski S, et al. Functional analysis of the \u22122548G\/A leptin gene polymorphism in breast cancer cells. Int J Cancer. 2009;125(5):1038-44. doi: 10.1002\/ijc.24372","journal-title":"Int J Cancer"},{"issue":"5","key":"key20250716155106_B21","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.3906\/sag-1502-138","article-title":"The association of vaspin rs2236242 and leptin rs7799039 polymorphism with metabolic syndrome in Egyptian women","volume":"46","author":"Alnory","year":"2016","unstructured":"Alnory A, Gad H, Hegazy G, Shaker O. The association of vaspin rs2236242 and leptin rs7799039 polymorphism with metabolic syndrome in Egyptian women. Turk J Med Sci. 2016;46(5):1335-40. doi: 10.3906\/sag-1502-138","journal-title":"Turk J Med Sci"},{"key":"key20250716155106_B22","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.2147\/OTT.S190093","article-title":"Leptin rs7799039 (G2548A) polymorphism is associated with cancer risk: a meta-analysis involving 25,799 subjects","volume":"12","author":"Tang","year":"2019","unstructured":"Tang W, Kang M, Liu C, Qiu H. Leptin rs7799039 (G2548A) polymorphism is associated with cancer risk: a meta-analysis involving 25,799 subjects. Onco Targets Ther. 2019;12:2879-90. doi: 10.2147\/OTT.S190093","journal-title":"Onco Targets Ther"},{"key":"key20250716155106_B23","article-title":"Genetic polymorphisms and plasma concentrations of leptin (rs7799039) and adiponectin (rs17300539) are associated with obesity in children and adolescents","volume":"40","author":"Menezes","year":"2022","unstructured":"Menezes CA, Alves Junior ER, Costa GN, Dombroski TC, Mattos RT, Gomes JA, et al. Genetic polymorphisms and plasma concentrations of leptin (rs7799039) and adiponectin (rs17300539) are associated with obesity in children and adolescents. Rev Paul Pediatr. 2022;40:e2021030. doi: 10.1590\/1984-0462\/2022\/40\/2021030IN","journal-title":"Rev Paul Pediatr"},{"issue":"6","key":"key20250716155106_B24","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1080\/13813455.2023.2265078","article-title":"Leptin Rs7799039 polymorphism is associated with type 2 diabetes mellitus Egyptian patients","volume":"130","author":"Mohamed","year":"2024","unstructured":"Mohamed AA, Abo-Elmatty DM, Wahba AS, Esmail OE, Salim HS, Hegab WS, et al. Leptin Rs7799039 polymorphism is associated with type 2 diabetes mellitus Egyptian patients. Arch Physiol Biochem. 2024;130(6):742-54. doi: 10.1080\/13813455.2023.2265078","journal-title":"Arch Physiol Biochem"},{"issue":"3","key":"key20250716155106_B25","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1590\/1806-93042016000300002","article-title":"Polymorphisms in VEGF and KDR genes in the development of endometriosis: a systematic review","volume":"16","author":"Cardoso","year":"2016","unstructured":"Cardoso JV, Machado DE, Ferrari R, Silva MC, Berardo PT, Perini JA. Polymorphisms in VEGF and KDR genes in the development of endometriosis: a systematic review. Rev Bras Sa\u00fade Mater Infant. 2016;16(3):219-32. doi: 10.1590\/1806-93042016000300002","journal-title":"Rev Bras Sa\u00fade Mater Infant"},{"key":"key20250716155106_B26","doi-asserted-by":"crossref","first-page":"436589","DOI":"10.1155\/2013\/436589","article-title":"The importance and perspective of magnetic resonance imaging in the evaluation of endometriosis","volume":"2013","author":"Bianek-Bodzak","year":"2013","unstructured":"Bianek-Bodzak A, Szurowska E, Sawicki S, Liro M. The importance and perspective of magnetic resonance imaging in the evaluation of endometriosis. BioMed Res Int. 2013;2013:436589. doi: 10.1155\/2013\/436589","journal-title":"BioMed Res Int"}],"container-title":["Revista Brasileira de Ginecologia e Obstetr\u00edcia"],"original-title":[],"language":"en","deposited":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T15:51:14Z","timestamp":1752681074000},"score":1,"resource":{"primary":{"URL":"https:\/\/journalrbgo.org\/article\/leptin-receptor-polymorphism-increases-the-risk-of-painful-symptoms-in-brazilian-women-with-endometriosis\/"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":26,"alternative-id":["10.61622\/rbgo\/2025rbgo43"],"URL":"https:\/\/doi.org\/10.61622\/rbgo\/2025rbgo43","relation":{},"ISSN":["0100-7203","1806-9339"],"issn-type":[{"value":"0100-7203","type":"print"},{"value":"1806-9339","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]},"article-number":"e-rbgo43"}}