{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T22:37:49Z","timestamp":1784068669523,"version":"3.55.0"},"reference-count":37,"publisher":"National Academy of Sciences of Tajikistan","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["IBJ"],"DOI":"10.61882\/ibj.4934","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T15:16:38Z","timestamp":1765379798000},"page":"149-158","source":"Crossref","is-referenced-by-count":0,"title":["Engineering of the Caspase-3 Gene in Recombinant CHO Cells Caused More Apoptosis Resistance and enhanced Recombinant Protein Production Than the BAX Gene"],"prefix":"10.61882","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1982-8081","authenticated-orcid":false,"given":"Amirabbas","family":"Rahimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2406-5963","authenticated-orcid":false,"given":"Morteza","family":"Karimipoor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1458-4767","authenticated-orcid":false,"given":"Reza","family":"Mahdian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1837-4150","authenticated-orcid":false,"given":"Atefeh","family":"Alipour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2411-7903","authenticated-orcid":false,"given":"Saadi","family":"Hosseini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2518-7433","authenticated-orcid":false,"given":"Marzieh","family":"Mohammadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4301-3381","authenticated-orcid":false,"given":"Hooman","family":"Kaghazian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8123-0857","authenticated-orcid":false,"given":"Hosein","family":"Shahsavarani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5123-4155","authenticated-orcid":false,"given":"Mohammad Ali","family":"Shokrgozar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"48150","published-online":{"date-parts":[[2025,5,1]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002\/bit.28062"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/biot.201500082"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/bit.27548"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002\/btpr.3228"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymben.2006.05.005"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038\/35037710"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2023.108115"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007\/s12257-020-0093-7"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1038\/nrg3686"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibtech.2017.07.007"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007\/s13205-021-02680-4"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.5812\/ijpr-130236"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.5812\/ijpr-130236"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1101\/pdb.prot4455"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222312827"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-022-02020-0"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2021.646363"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1002\/bit.26969"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiec.2020.08.009"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1002\/biot.200700249"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2019.00420"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-27851-y"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2022.119317"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1007\/s00436-023-08031-x"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-44084-3"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2016.253"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-024-01273-x"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1093\/evlett\/qrad057"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2022.01.008"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.43.30651"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1002\/biot.201800477"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.1002\/bit.27269"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.1002\/bit.25233"},{"key":"ref67","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-82215-2"},{"key":"ref69","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-49067-6"},{"key":"ref71","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2016.132"},{"key":"ref73","doi-asserted-by":"publisher","DOI":"10.1080\/01926230701320337"}],"container-title":["Iranian Biomedical Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/ibj.pasteur.ac.ir\/article-1-4934-en.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ibj.pasteur.ac.ir\/article-1-4934-en.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T15:17:14Z","timestamp":1765379834000},"score":1,"resource":{"primary":{"URL":"https:\/\/ibj.pasteur.ac.ir\/article-1-4934-en.html"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,1]]},"references-count":37,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,5,1]]}},"URL":"https:\/\/doi.org\/10.61882\/ibj.4934","relation":{},"ISSN":["2074-1847"],"issn-type":[{"value":"2074-1847","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,1]]}}}