{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T16:33:35Z","timestamp":1778690015367,"version":"3.51.4"},"reference-count":27,"publisher":"e-Century Publishing Corporation","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Stem Cells"],"DOI":"10.62347\/aeiv5813","type":"journal-article","created":{"date-parts":[[2024,9,13]],"date-time":"2024-09-13T02:57:26Z","timestamp":1726196246000},"page":"212-221","source":"Crossref","is-referenced-by-count":2,"title":["Exploring the application of stem cell technology in treating sensorineural hearing loss"],"prefix":"10.62347","volume":"13","author":[{"given":"Min","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"48694","published-online":{"date-parts":[[2024]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"Tordrup D, Smith R, Kamenov K, Bertram MY, Green N and Chadha S; WHO HEAR group. Global return on investment and cost-effectiveness of WHO’s HEAR interventions for hearing loss: a modelling study. Lancet Glob Health 2022; 10: e52-e62.","DOI":"10.1016\/S2214-109X(21)00447-2"},{"key":"ref1","doi-asserted-by":"publisher","first-page":"109287","DOI":"10.1016\/j.clim.2023.109287","article-title":"The NLRP3 inflammasome as a target for sensorineural hearing loss","volume":"249","author":"Gregory","year":"2023","unstructured":"Gregory GE, Munro KJ, Couper KN, Pathmanaban ON and Brough D. The NLRP3 inflammasome as a target for sensorineural hearing loss. Clin Immunol 2023; 249: 109287.","journal-title":"Clin Immunol"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1080\/14992027.2019.1689432","article-title":"Contemporary review of the causes and differential diagnosis of sudden sensorineural hearing loss","volume":"59","author":"Young","year":"2020","unstructured":"Young YH. Contemporary review of the causes and differential diagnosis of sudden sensorineural hearing loss. Int J Audiol 2020; 59: 243-253.","journal-title":"Int J Audiol"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1080\/13543784.2023.2242253","article-title":"Experimental drugs for the prevention or treatment of sensorineural hearing loss","volume":"32","author":"Kempfle","year":"2023","unstructured":"Kempfle JS and Jung DH. Experimental drugs for the prevention or treatment of sensorineural hearing loss. Expert Opin Investig Drugs 2023; 32: 643-654.","journal-title":"Expert Opin Investig Drugs"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"108209","DOI":"10.1016\/j.heares.2021.108209","article-title":"Development of ebselen for the treatment of sensorineural hearing loss and tinnitus","volume":"413","author":"Kil","year":"2022","unstructured":"Kil J, Harruff EE and Longenecker RJ. Development of ebselen for the treatment of sensorineural hearing loss and tinnitus. Hear Res 2022; 413: 108209.","journal-title":"Hear Res"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"636","DOI":"10.1055\/s-0041-1728677","article-title":"Advancements in stem cell technology and organoids for the restoration of sensorineural hearing loss","volume":"32","author":"Bergman","year":"2021","unstructured":"Bergman JE, Davies C, Denton AJ, Ashman PE, Mittal R and Eshraghi AA. Advancements in stem cell technology and organoids for the restoration of sensorineural hearing loss. J Am Acad Audiol 2021; 32: 636-645.","journal-title":"J Am Acad Audiol"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.arr.2017.04.002","article-title":"Recent advances in cochlear hair cell regeneration-A promising opportunity for the treatment of age-related hearing loss","volume":"36","author":"Revuelta","year":"2017","unstructured":"Revuelta M, Santaolalla F, Arteaga O, Alvarez A, Sánchez-del-Rey A and Hilario E. Recent advances in cochlear hair cell regeneration-A promising opportunity for the treatment of age-related hearing loss. Ageing Res Rev 2017; 36: 149-155.","journal-title":"Ageing Res Rev"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"83","DOI":"10.3342\/ceo.2015.8.2.83","article-title":"Neural-induced human mesenchymal stem cells promote cochlear cell regeneration in deaf Guinea pigs","volume":"8","author":"Jang","year":"2015","unstructured":"Jang S, Cho HH, Kim SH, Lee KH, Jun JY, Park JS, Jeong HS and Cho YB. Neural-induced human mesenchymal stem cells promote cochlear cell regeneration in deaf Guinea pigs. Clin Exp Otorhinolaryngol 2015; 8: 83-91.","journal-title":"Clin Exp Otorhinolaryngol"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"1709","DOI":"10.1044\/1092-4388(2011\/10-0149)","article-title":"Biotechnology in the treatment of sensorineural hearing loss: foundations and future of hair cell regeneration","volume":"54","author":"Parker","year":"2011","unstructured":"Parker MA. Biotechnology in the treatment of sensorineural hearing loss: foundations and future of hair cell regeneration. J Speech Lang Hear Res 2011; 54: 1709-31.","journal-title":"J Speech Lang Hear Res"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1258\/ebm.2009.009281","article-title":"The challenge of hair cell regeneration","volume":"235","author":"Groves","year":"2010","unstructured":"Groves AK. The challenge of hair cell regeneration. Exp Biol Med (Maywood) 2010; 235: 434-46.","journal-title":"Exp Biol Med (Maywood)"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"8829660","DOI":"10.1155\/2020\/8829660","article-title":"Stem cell-based therapeutic approaches to restore sensorineural hearing loss in mammals","volume":"2020","author":"Waqas","year":"2020","unstructured":"Waqas M, Us-Salam I, Bibi Z, Wang Y, Li H, Zhu Z and He S. Stem cell-based therapeutic approaches to restore sensorineural hearing loss in mammals. Neural Plast 2020; 2020: 8829660.","journal-title":"Neural Plast"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1186\/s13287-021-02403-9","article-title":"Selective ablation of cochlear hair cells promotes engraftment of human embryonic stem cell-derived progenitors in the mouse organ of Corti","volume":"12","author":"Takeda","year":"2021","unstructured":"Takeda H, Dondzillo A, Randall JA and Gubbels SP. Selective ablation of cochlear hair cells promotes engraftment of human embryonic stem cell-derived progenitors in the mouse organ of Corti. Stem Cell Res Ther 2021; 12: 352.","journal-title":"Stem Cell Res Ther"},{"key":"ref12","unstructured":"Wu X, Zou S, Wu F, He Z and Kong W. Role of microRNA in inner ear stem cells and related research progress. Am J Stem Cells 2020; 9: 16-24."},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"Waqas M and Chai R. Approaches to regenerate hair cell and spiral ganglion neuron in the inner ear. 2020.","DOI":"10.1007\/978-3-030-40413-0_4"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.ydbio.2018.12.025","article-title":"Atoh1 and other related key regulators in the development of auditory sensory epithelium in the mammalian inner ear: function and interplay","volume":"446","author":"Zhong","year":"2019","unstructured":"Zhong C, Fu Y, Pan W, Yu J and Wang J. Atoh1 and other related key regulators in the development of auditory sensory epithelium in the mammalian inner ear: function and interplay. Dev Biol 2019; 446: 133-141.","journal-title":"Dev Biol"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"107981","DOI":"10.1016\/j.heares.2020.107981","article-title":"Gene therapy for hair cell regeneration: review and new data","volume":"394","author":"Shibata","year":"2020","unstructured":"Shibata SB, West MB, Du X, Iwasa Y, Raphael Y and Kopke RD. Gene therapy for hair cell regeneration: review and new data. Hear Res 2020; 394: 107981.","journal-title":"Hear Res"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"13","DOI":"10.21873\/invivo.12227","article-title":"Therapeutic application of mesenchymal stem cells for cochlear regeneration","volume":"35","author":"Maharajan","year":"2021","unstructured":"Maharajan N, Cho GW and Jang CH. Therapeutic application of mesenchymal stem cells for cochlear regeneration. In Vivo 2021; 35: 13-22.","journal-title":"In Vivo"},{"key":"ref17","doi-asserted-by":"publisher","unstructured":"Lush ME, Diaz DC, Koenecke N, Baek S, Boldt H, St Peter MK, Gaitan-Escudero T, Romero-Carvajal A, Busch-Nentwich EM, Perera AG, Hall KE, Peak A, Haug JS and Piotrowski T. scRNA-Seq reveals distinct stem cell populations that drive hair cell regeneration after loss of Fgf and Notch signaling. Elife 2019; 8: e44431.","DOI":"10.7554\/eLife.44431"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/978-981-13-6123-4_1","article-title":"Hair cell regeneration","volume":"1130","author":"Chen","year":"2019","unstructured":"Chen Y, Zhang S, Chai R and Li H. Hair cell regeneration. Adv Exp Med Biol 2019; 1130: 1-16.","journal-title":"Adv Exp Med Biol"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1016\/j.ymthe.2019.03.018","article-title":"Engraftment of human stem cell-derived otic progenitors in the damaged cochlea","volume":"27","author":"Lopez-Juarez","year":"2019","unstructured":"Lopez-Juarez A, Lahlou H, Ripoll C, Cazals Y, Brezun JM, Wang Q, Edge A and Zine A. Engraftment of human stem cell-derived otic progenitors in the damaged cochlea. Mol Ther 2019; 27: 1101-1113.","journal-title":"Mol Ther"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"Dufner-Almeida LG, Cruz DBD, Mingroni Netto RC, Batissoco AC, Oiticica J and Salazar-Silva R. Stem-cell therapy for hearing loss: are we there yet? Braz J Otorhinolaryngol 2019; 85: 520-529.","DOI":"10.1016\/j.bjorl.2019.04.006"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"567","DOI":"10.1146\/annurev-cellbio-100818-125503","article-title":"Comparing sensory organs to define the path for hair cell regeneration","volume":"35","author":"Denans","year":"2019","unstructured":"Denans N, Baek S and Piotrowski T. Comparing sensory organs to define the path for hair cell regeneration. Annu Rev Cell Dev Biol 2019; 35: 567-589.","journal-title":"Annu Rev Cell Dev Biol"},{"key":"ref22","doi-asserted-by":"publisher","first-page":"6729","DOI":"10.1080\/21655979.2022.2045835","article-title":"Small activating RNA activation of ATOH1 promotes regeneration of human inner ear hair cells","volume":"13","author":"Zhang","year":"2022","unstructured":"Zhang YL, Kang M, Wu JC, Xie MY, Xue RY, Tang Q, Yang H and Li LC. Small activating RNA activation of ATOH1 promotes regeneration of human inner ear hair cells. Bioengineered 2022; 13: 6729-6739.","journal-title":"Bioengineered"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"792089","DOI":"10.3389\/fncel.2022.792089","article-title":"Hearing recovery induced by DNA demethylation in a chemically deafened adult mouse model","volume":"16","author":"Deng","year":"2022","unstructured":"Deng X and Hu Z. Hearing recovery induced by DNA demethylation in a chemically deafened adult mouse model. Front Cell Neurosci 2022; 16: 792089.","journal-title":"Front Cell Neurosci"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1007\/978-981-13-6123-4_10","article-title":"Stem cells: a new hope for hearing loss therapy","volume":"1130","author":"Qiu","year":"2019","unstructured":"Qiu Y and Qiu J. Stem cells: a new hope for hearing loss therapy. Adv Exp Med Biol 2019; 1130: 165-180.","journal-title":"Adv Exp Med Biol"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"3692937","DOI":"10.1155\/2020\/3692937","article-title":"Generation of otic lineages from integration-free human-induced pluripotent stem cells reprogrammed by mRNAs","volume":"2020","author":"Boddy","year":"2020","unstructured":"Boddy SL, Romero-Guevara R, Ji AR, Unger C, Corns L, Marcotti W and Rivolta MN. Generation of otic lineages from integration-free human-induced pluripotent stem cells reprogrammed by mRNAs. Stem Cells Int 2020; 2020: 3692937.","journal-title":"Stem Cells Int"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1002\/stem.3346","article-title":"A human induced pluripotent stem cell-based modular platform to challenge sensorineural hearing loss","volume":"39","author":"Zine","year":"2021","unstructured":"Zine A, Messat Y and Fritzsch B. A human induced pluripotent stem cell-based modular platform to challenge sensorineural hearing loss. Stem Cells 2021; 39: 697-706.","journal-title":"Stem Cells"}],"container-title":["American Journal of Stem Cells"],"original-title":[],"link":[{"URL":"https:\/\/e-century.us\/files\/ajsc\/13\/4\/ajsc0155783.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T01:55:01Z","timestamp":1766022901000},"score":1,"resource":{"primary":{"URL":"https:\/\/e-century.us\/files\/ajsc\/13\/4\/ajsc0155783.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024]]},"references-count":27,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2024]]}},"URL":"https:\/\/doi.org\/10.62347\/aeiv5813","relation":{},"ISSN":["2160-4150"],"issn-type":[{"value":"2160-4150","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024]]}}}