{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T09:51:14Z","timestamp":1789638674489,"version":"4.0.0"},"reference-count":35,"publisher":"e-Century Publishing Corporation","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Transl Res"],"DOI":"10.62347\/ahto9889","type":"journal-article","created":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T09:28:32Z","timestamp":1756373312000},"page":"6359-6369","source":"Crossref","is-referenced-by-count":2,"title":["Effects of celecoxib combined with glucosamine hydrochloride in the management of knee osteoarthritis"],"prefix":"10.62347","volume":"17","author":[{"given":"Lv","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"48694","published-online":{"date-parts":[[2025]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","first-page":"347","DOI":"10.3233\/BMR-181294","article-title":"Long-term effects of intra-articular oxygen-ozone therapy versus hyaluronic acid in older people affected by knee osteoarthritis: a randomized single-blind extension study","volume":"33","author":"de Sire","year":"2020","unstructured":"de Sire A, Stagno D, Minetto MA, Cisari C, Baricich A and Invernizzi M. Long-term effects of intra-articular oxygen-ozone therapy versus hyaluronic acid in older people affected by knee osteoarthritis: a randomized single-blind extension study. J Back Musculoskelet Rehabil 2020; 33: 347-354.","journal-title":"J Back Musculoskelet Rehabil"},{"key":"ref1","doi-asserted-by":"publisher","first-page":"635","DOI":"10.1186\/s12877-022-03331-w","article-title":"Mediating effect of self-efficacy on the relationship between social support and self-management behaviors among patients with knee osteoarthritis: a cross-sectional study","volume":"22","author":"Chen","year":"2022","unstructured":"Chen YY, Weng LC, Li YT and Huang HL. Mediating effect of self-efficacy on the relationship between social support and self-management behaviors among patients with knee osteoarthritis: a cross-sectional study. BMC Geriatr 2022; 22: 635.","journal-title":"BMC Geriatr"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"1743","DOI":"10.1002\/acr.22897","article-title":"Number of persons with symptomatic knee osteoarthritis in the us: impact of race and ethnicity, age, sex, and obesity","volume":"68","author":"Deshpande","year":"2016","unstructured":"Deshpande BR, Katz JN, Solomon DH, Yelin EH, Hunter DJ, Messier SP, Suter LG and Losina E. Number of persons with symptomatic knee osteoarthritis in the us: impact of race and ethnicity, age, sex, and obesity. Arthritis Care Res (Hoboken) 2016; 68: 1743-1750.","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"ref3","unstructured":"Balsamo S, Diniz LR, dos Santos-Neto LL and da Mota LM. Exercise and fatigue in rheumatoid arthritis. Isr Med Assoc J 2014; 16: 57-60."},{"key":"ref4","doi-asserted-by":"publisher","first-page":"1613","DOI":"10.1002\/acr.20587","article-title":"Effect of self-efficacy and physical activity goal achievement on arthritis pain and quality of life in patients with rheumatoid arthritis","volume":"63","author":"Knittle","year":"2011","unstructured":"Knittle KP, De Gucht V, Hurkmans EJ, Vlieland TP, Peeters AJ, Ronday HK and Maes S. Effect of self-efficacy and physical activity goal achievement on arthritis pain and quality of life in patients with rheumatoid arthritis. Arthritis Care Res (Hoboken) 2011; 63: 1613-1619.","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"2970","DOI":"10.1007\/s00167-019-05725-7","article-title":"There is no difference in postoperative pain, function and complications in patients with chondrocalcinosis in the outcome of total knee arthroplasty for end-stage osteoarthritis","volume":"28","author":"Willems","year":"2020","unstructured":"Willems JH, Rassir R, Sierevelt IN and Nolte PA. There is no difference in postoperative pain, function and complications in patients with chondrocalcinosis in the outcome of total knee arthroplasty for end-stage osteoarthritis. Knee Surg Sports Traumatol Arthrosc 2020; 28: 2970-2979.","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"Lin X, Zhi F, Lan Q, Deng W, Hou X and Wan Q. Comparing the efficacy of different intra-articular injections for knee osteoarthritis: a network analysis. Medicine (Baltimore) 2022; 101: e29655.","DOI":"10.1097\/MD.0000000000029655"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1002\/acr.21596","article-title":"American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee","volume":"64","author":"MC","year":"2012","unstructured":"Hochberg MC, Altman RD, April KT, Benkhalti M, Guyatt G, McGowan J, Towheed T, Welch V, Wells G and Tugwell P; American College of Rheumatology. American College of Rheumatology 2012 recommendations for the use of nonpharmacologic and pharmacologic therapies in osteoarthritis of the hand, hip, and knee. Arthritis Care Res (Hoboken) 2012; 64: 465-474.","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"891","DOI":"10.4103\/0366-6999.179789","article-title":"Efficacy and safety of Zhuanggu joint capsules in combination with celecoxib in knee osteoarthritis: a multi-center, randomized, double-blind, double-dummy, and parallel controlled trial","volume":"129","author":"Zhang","year":"2016","unstructured":"Zhang XL, Yang J, Yang L, Liu JG, Cai XY, Fan WM, Yun XQ, Ma JZ and Weng XS. Efficacy and safety of Zhuanggu joint capsules in combination with celecoxib in knee osteoarthritis: a multi-center, randomized, double-blind, double-dummy, and parallel controlled trial. Chin Med J (Engl) 2016; 129: 891-897.","journal-title":"Chin Med J (Engl)"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1177\/0091270011412184","article-title":"Dosing celecoxib in pediatric patients with juvenile rheumatoid arthritis","volume":"52","author":"Krishnaswami","year":"2012","unstructured":"Krishnaswami S, Hutmacher MM, Robbins JL, Bello A, West C and Bloom BJ. Dosing celecoxib in pediatric patients with juvenile rheumatoid arthritis. J Clin Pharmacol 2012; 52: 1134-1149.","journal-title":"J Clin Pharmacol"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1016\/j.joca.2014.01.003","article-title":"OARSI guidelines for the non-surgical management of knee osteoarthritis","volume":"22","author":"McAlindon","year":"2014","unstructured":"McAlindon TE, Bannuru RR, Sullivan MC, Arden NK, Berenbaum F, Bierma-Zeinstra SM, Hawker GA, Henrotin Y, Hunter DJ, Kawaguchi H, Kwoh K, Lohmander S, Rannou F, Roos EM and Underwood M. OARSI guidelines for the non-surgical management of knee osteoarthritis. Osteoarthritis Cartilage 2014; 22: 363-388.","journal-title":"Osteoarthritis Cartilage"},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1009","DOI":"10.1007\/s00296-008-0561-4","article-title":"Chondroprotective effects of glucosamine involving the p38 MAPK and Akt signaling pathways","volume":"28","author":"Lin","year":"2008","unstructured":"Lin YC, Liang YC, Sheu MT, Lin YC, Hsieh MS, Chen TF and Chen CH. Chondroprotective effects of glucosamine involving the p38 MAPK and Akt signaling pathways. Rheumatol Int 2008; 28: 1009-1016.","journal-title":"Rheumatol Int"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1111\/1756-185X.13239","article-title":"Effects of oral glucosamine hydrochloride and mucopolysaccharide protein in a rabbit model of osteoarthritis","volume":"21","author":"Jeong","year":"2018","unstructured":"Jeong DH, Ullah HMA, Goo MJ, Ghim SG, Hong IH, Kim AY, Jeon SM, Choi MS, Elfadl AK, Chung MJ, Lee EJ, Kim YD, Kim JH, Kim SY and Jeong KS. Effects of oral glucosamine hydrochloride and mucopolysaccharide protein in a rabbit model of osteoarthritis. Int J Rheum Dis 2018; 21: 620-628.","journal-title":"Int J Rheum Dis"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"146465","DOI":"10.1016\/j.gene.2022.146465","article-title":"Aerobic exercise combined with glucosamine hydrochloride capsules inhibited the apoptosis of chondrocytes in rabbit knee osteoarthritis by affecting TRPV5 expression","volume":"830","author":"Chen","year":"2022","unstructured":"Chen B, Fang L, Lin L, Lv Y, Huang Z, Lin X and Wang X. Aerobic exercise combined with glucosamine hydrochloride capsules inhibited the apoptosis of chondrocytes in rabbit knee osteoarthritis by affecting TRPV5 expression. Gene 2022; 830: 146465.","journal-title":"Gene"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"9167956","DOI":"10.1155\/2022\/9167956","article-title":"Effects of warm acupuncture combined with meloxicam and comprehensive nursing on pain improvement and joint function in patients with knee osteoarthritis","volume":"2022","author":"Sun","year":"2022","unstructured":"Sun Z, Qu X, Wang T, Liu F and Li X. Effects of warm acupuncture combined with meloxicam and comprehensive nursing on pain improvement and joint function in patients with knee osteoarthritis. J Healthc Eng 2022; 2022: 9167956.","journal-title":"J Healthc Eng"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"Zhao C, Hao X, Cai W, Zeng LF, Zhao W and Li X. Colchicine combination therapy increases treatment tolerance in patients with arthritis: a systematic review and meta-analysis. PLoS One 2024; 19: e0316126.","DOI":"10.1371\/journal.pone.0316126"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.jor.2024.02.021","article-title":"Extracorporeal shockwave therapy in the management of knee osteoarthritis: a systematic review of dose-response meta-analysis","volume":"52","author":"TY","year":"2024","unstructured":"Chen TY, Chou SH and Shih CL. Extracorporeal shockwave therapy in the management of knee osteoarthritis: a systematic review of dose-response meta-analysis. J Orthop 2024; 52: 67-73.","journal-title":"J Orthop"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"2924","DOI":"10.1007\/s12325-024-02898-7","article-title":"Correlation between coronal position sequence of lumbar and WOMAC Score in Knee Osteoarthritis (KOA) in standard standing position","volume":"41","author":"Du","year":"2024","unstructured":"Du P, Yan Y, Yin S, Li X, Wang H, Sun J, Kang K, Zhao J and Du S. Correlation between coronal position sequence of lumbar and WOMAC Score in Knee Osteoarthritis (KOA) in standard standing position. Adv Ther 2024; 41: 2924-2935.","journal-title":"Adv Ther"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"3938","DOI":"10.62347\/BHGS1734","article-title":"Application of multi-disciplinary team nursing model enhances recovery after surgery for total hip arthroplasty and total knee arthroplasty","volume":"16","author":"Zhou","year":"2024","unstructured":"Zhou X and Wei T. Application of multi-disciplinary team nursing model enhances recovery after surgery for total hip arthroplasty and total knee arthroplasty. Am J Transl Res 2024; 16: 3938-3949.","journal-title":"Am J Transl Res"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"1758","DOI":"10.1002\/ptr.8210","article-title":"Total glucosides of white paeony capsule alleviate articular cartilage degeneration and aberrant subchondral bone remodeling in knee osteoarthritis","volume":"39","author":"Liao","year":"2025","unstructured":"Liao T, Kang J, Ma Z, Jie L, Feng M, Liu D, Mao J, Wang P and Xing R. Total glucosides of white paeony capsule alleviate articular cartilage degeneration and aberrant subchondral bone remodeling in knee osteoarthritis. Phytother Res 2025; 39: 1758-1775.","journal-title":"Phytother Res"},{"key":"ref20","doi-asserted-by":"publisher","unstructured":"Rodriguez-Garcia SC, Castellanos-Moreira R, Uson J, Naredo E, O’Neill TW, Doherty M, Boesen M, Pandit H, Moller Parera I, Vardanyan V, Terslev L, Kampen WU, D’Agostino MA, Berenbaum F, Nikiphorou E, Pitsillidou I, de la Torre-Aboki J and Carmona L. Efficacy and safety of intra-articular therapies in rheumatic and musculoskeletal diseases: an overview of systematic reviews. RMD Open 2021; 7: e001658.","DOI":"10.1136\/rmdopen-2021-001658"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1038\/nrrheum.2014.44","article-title":"The individual and socioeconomic impact of osteoarthritis","volume":"10","author":"DJ","year":"2014","unstructured":"Hunter DJ, Schofield D and Callander E. The individual and socioeconomic impact of osteoarthritis. Nat Rev Rheumatol 2014; 10: 437-441.","journal-title":"Nat Rev Rheumatol"},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"Thorlund JB, Juhl CB, Roos EM and Lohmander LS. Arthroscopic surgery for degenerative knee: systematic review and meta-analysis of benefits and harms. BMJ 2015; 350: h2747.","DOI":"10.1136\/bmj.h2747"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"3028","DOI":"10.2174\/0929867328666210910125229","article-title":"The role of celecoxib as a potential inhibitor in the treatment of inflammatory diseases - a review","volume":"29","author":"Cruz","year":"2022","unstructured":"Cruz JV, Rosa JMC, Kimani NM, Giuliatti S and Dos Santos CBR. The role of celecoxib as a potential inhibitor in the treatment of inflammatory diseases - a review. Curr Med Chem 2022; 29: 3028-3049.","journal-title":"Curr Med Chem"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1177\/1947603515603762","article-title":"Glucosamine hydrochloride but not chondroitin sulfate prevents cartilage degradation and inflammation induced by interleukin-1alpha in bovine cartilage explants","volume":"7","author":"Bascoul-Colombo","year":"2016","unstructured":"Bascoul-Colombo C, Garaiova I, Plummer SF, Harwood JL, Caterson B and Hughes CE. Glucosamine hydrochloride but not chondroitin sulfate prevents cartilage degradation and inflammation induced by interleukin-1alpha in bovine cartilage explants. Cartilage 2016; 7: 70-81.","journal-title":"Cartilage"},{"key":"ref25","unstructured":"El Hajjaji H, Marcelis A, Devogelaer JP and Manicourt DH. Celecoxib has a positive effect on the overall metabolism of hyaluronan and proteoglycans in human osteoarthritic cartilage. J Rheumatol 2003; 30: 2444-2451."},{"key":"ref26","unstructured":"Wang Z, Wang J, Zhang L, Meng X, Dai G and Wang Q. Diacerein plus glucosamine hydrochloride improves the safety and efficacy and inhibit inflammatory factors in the treatment of knee osteoarthritis. Am J Transl Res 2023; 15: 548-555."},{"key":"ref27","doi-asserted-by":"publisher","first-page":"58","DOI":"10.1186\/s13063-018-3111-8","article-title":"Cerebral mechanism of celecoxib for treating knee pain: study protocol for a randomized controlled parallel trial","volume":"20","author":"Tang","year":"2019","unstructured":"Tang C, Dong X, He W, Cheng S, Chen Y, Huang Y, Yin B, Sheng Y, Zhou J, Wu X, Zeng F, Li Z and Liang F. Cerebral mechanism of celecoxib for treating knee pain: study protocol for a randomized controlled parallel trial. Trials 2019; 20: 58.","journal-title":"Trials"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1002\/jsfa.4660","article-title":"Effect of a dietary supplement containing glucosamine hydrochloride, chondroitin sulfate and quercetin glycosides on symptomatic knee osteoarthritis: a randomized, double-blind, placebo-controlled study","volume":"92","author":"Kanzaki","year":"2012","unstructured":"Kanzaki N, Saito K, Maeda A, Kitagawa Y, Kiso Y, Watanabe K, Tomonaga A, Nagaoka I and Yamaguchi H. Effect of a dietary supplement containing glucosamine hydrochloride, chondroitin sulfate and quercetin glycosides on symptomatic knee osteoarthritis: a randomized, double-blind, placebo-controlled study. J Sci Food Agric 2012; 92: 862-869.","journal-title":"J Sci Food Agric"},{"key":"ref29","doi-asserted-by":"publisher","unstructured":"Wang X, Hu B, Cheng Y, Chen W and Liu M. Effects of different doses of glucosamine hydrochloride on cartilage tissue and levels of joint injury markers in knee osteoarthritis. J Cell Mol Med 2025; 29: e70579.","DOI":"10.1111\/jcmm.70579"},{"key":"ref30","unstructured":"Wang F, Liu G, Shi J, Wang J, Zheng S, Shi Q and Pan H. Effects of glucosamine hydrochloride combined with non-steroidal anti-inflammatory drugs on symptoms and HSS scores in patients with knee osteoarthritis. Pak J Pharm Sci 2023; 36: 921-925."},{"key":"ref31","doi-asserted-by":"publisher","first-page":"443","DOI":"10.5312\/wjo.v14.i6.443","article-title":"Chondroitin sulfate and glucosamine combination in patients with knee and hip osteoarthritis: a long-term observational study in Russia","volume":"14","author":"Lila","year":"2023","unstructured":"Lila AM, Alekseeva LI, Baranov AA, Taskina EA, Kashevarova NG, Lapkina NA and Trofimov EA. Chondroitin sulfate and glucosamine combination in patients with knee and hip osteoarthritis: a long-term observational study in Russia. World J Orthop 2023; 14: 443-457.","journal-title":"World J Orthop"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"6078254","DOI":"10.1155\/2022\/6078254","article-title":"Clinical efficacy of glucosamine plus sodium hyaluronate for osteoporosis complicated by knee osteoarthritis and its influence on joint function and bone metabolic markers","volume":"2022","author":"Yang","year":"2022","unstructured":"Yang JJ and Zhang XM. Clinical efficacy of glucosamine plus sodium hyaluronate for osteoporosis complicated by knee osteoarthritis and its influence on joint function and bone metabolic markers. Comput Math Methods Med 2022; 2022: 6078254.","journal-title":"Comput Math Methods Med"},{"key":"ref33","unstructured":"Zhang J, Ge R and Yang Z. Effect of celecoxib combined with glucosamine hydrochloride in promoting the functional recovery and decreasing the inflammatory factor levels in patients with knee osteoarthritis. Pak J Pharm Sci 2021; 34: 1277-1282."},{"key":"ref34","doi-asserted-by":"publisher","unstructured":"Liu MH, He K and Liu F. Clinical effect of glucosamine hydrochloride combined with compound osteopeptide injection for knee osteoarthritis. Pak J Med Sci 2023; 39: 1809-1813.","DOI":"10.12669\/pjms.39.6.8151"}],"container-title":["American Journal of Translational Research"],"original-title":[],"link":[{"URL":"https:\/\/e-century.us\/files\/ajtr\/17\/8\/ajtr0165327.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T02:00:05Z","timestamp":1766023205000},"score":1,"resource":{"primary":{"URL":"https:\/\/e-century.us\/files\/ajtr\/17\/8\/ajtr0165327.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":35,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.62347\/ahto9889","relation":{},"ISSN":["1943-8141"],"issn-type":[{"value":"1943-8141","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}