{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T02:02:22Z","timestamp":1766023342707,"version":"3.48.0"},"reference-count":33,"publisher":"e-Century Publishing Corporation","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Clin Exp Immunol"],"DOI":"10.62347\/bzpe6333","type":"journal-article","created":{"date-parts":[[2025,6,30]],"date-time":"2025-06-30T23:32:58Z","timestamp":1751326378000},"page":"127-137","source":"Crossref","is-referenced-by-count":0,"title":["Dcun1d3 is dispensable for spermatogenesis and male fertility in mice"],"prefix":"10.62347","volume":"14","author":[{"given":"Meng","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"48694","published-online":{"date-parts":[[2025]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.semcdb.2016.04.009","article-title":"Spermatogenesis in humans and its affecting factors","volume":"59","author":"Neto","year":"2016","unstructured":"Neto FT, Bach PV, Najari BB, Li PS and Goldstein M. Spermatogenesis in humans and its affecting factors. Semin Cell Dev Biol 2016; 59: 10-26.","journal-title":"Semin Cell Dev Biol"},{"key":"ref1","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1016\/j.gendis.2023.02.030","article-title":"X-box binding protein 1 caused an imbalance in pyroptosis and mitophagy in immature rats with di-(2-ethylhexyl) phthalate-induced testis toxicity","volume":"11","author":"Hong","year":"2024","unstructured":"Hong Y, Zhou X, Li Q, Chen J, Wei Y, Long C, Shen L, Zheng X, Li D, Wang X, Yu C, Wu S and Wei G. X-box binding protein 1 caused an imbalance in pyroptosis and mitophagy in immature rats with di-(2-ethylhexyl) phthalate-induced testis toxicity. Genes Dis 2024; 11: 935-951.","journal-title":"Genes Dis"},{"key":"ref2","doi-asserted-by":"publisher","first-page":"18714","DOI":"10.1074\/jbc.RA119.010496","article-title":"Distinct H3K9me3 and DNA methylation modifications during mouse spermatogenesis","volume":"294","author":"Liu","year":"2019","unstructured":"Liu Y, Zhang Y, Yin J, Gao Y, Li Y, Bai D, He W, Li X, Zhang P, Li R, Zhang L, Jia Y, Zhang Y, Lin J, Zheng Y, Wang H, Gao S, Zeng W and Liu W. Distinct H3K9me3 and DNA methylation modifications during mouse spermatogenesis. J Biol Chem 2019; 294: 18714-18725.","journal-title":"J Biol Chem"},{"key":"ref3","doi-asserted-by":"publisher","unstructured":"Jahns MT, Vezon D, Chambon A, Pereira L, Falque M, Martin OC, Chelysheva L and Grelon M. Crossover localisation is regulated by the neddylation posttranslational regulatory pathway. PLoS Biol 2014; 12: e1001930.","DOI":"10.1371\/journal.pbio.1001930"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1038\/nrm3919","article-title":"Protein neddylation: beyond cullin-RING ligases","volume":"16","author":"RI","year":"2015","unstructured":"Enchev RI, Schulman BA and Peter M. Protein neddylation: beyond cullin-RING ligases. Nat Rev Mol Cell Biol 2015; 16: 30-44.","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref5","doi-asserted-by":"publisher","first-page":"1441","DOI":"10.1242\/jcs.181784","article-title":"Characterization of the mammalian family of DCN-type NEDD8 E3 ligases","volume":"129","author":"Keuss","year":"2016","unstructured":"Keuss MJ, Thomas Y, McArthur R, Wood NT, Knebel A and Kurz T. Characterization of the mammalian family of DCN-type NEDD8 E3 ligases. J Cell Sci 2016; 129: 1441-1454.","journal-title":"J Cell Sci"},{"key":"ref6","doi-asserted-by":"publisher","unstructured":"Huang G, Kaufman AJ, Ryan RJH, Romin Y, Huryn L, Bains S, Manova-Todorova K, Morris PL, Hunnicutt GR, Adelman CA, Petrini JHJ, Ramanathan Y and Singh B. Mouse DCUN1D1 (SCCRO) is required for spermatogenetic individualization. PLoS One 2019; 14: e0209995.","DOI":"10.1371\/journal.pone.0209995"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"2128","DOI":"10.1111\/j.1349-7006.2008.00929.x","article-title":"DCUN1D3, a novel UVC-responsive gene that is involved in cell cycle progression and cell growth","volume":"99","author":"Ma","year":"2008","unstructured":"Ma T, Shi T, Huang J, Wu L, Hu F, He P, Deng W, Gao P, Zhang Y, Song Q, Ma D and Qiu X. DCUN1D3, a novel UVC-responsive gene that is involved in cell cycle progression and cell growth. Cancer Sci 2008; 99: 2128-2135.","journal-title":"Cancer Sci"},{"key":"ref8","doi-asserted-by":"publisher","first-page":"34728","DOI":"10.1074\/jbc.M114.585505","article-title":"SCCRO3 (DCUN1D3) antagonizes the neddylation and oncogenic activity of SCCRO (DCUN1D1)","volume":"289","author":"Huang","year":"2014","unstructured":"Huang G, Stock C, Bommeljé CC, Weeda VB, Shah K, Bains S, Buss E, Shaha M, Rechler W, Ramanathan SY and Singh B. SCCRO3 (DCUN1D3) antagonizes the neddylation and oncogenic activity of SCCRO (DCUN1D1). J Biol Chem 2014; 289: 34728-34742.","journal-title":"J Biol Chem"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"88","DOI":"10.62347\/VLDZ7581","article-title":"Identification of macrophage-related genes in bladder cancer patients using single-cell sequencing and construction of a prognostic model","volume":"13","author":"Wang","year":"2024","unstructured":"Wang W, Shen J, Song D, Fu K and Fu X. Identification of macrophage-related genes in bladder cancer patients using single-cell sequencing and construction of a prognostic model. Am J Clin Exp Immunol 2024; 13: 88-104.","journal-title":"Am J Clin Exp Immunol"},{"key":"ref10","unstructured":"Xue J and Lv J. Analytical approach for specific populations at single-cell resolution: insights for ND-42 mediated mitochondrial derivative function during spermatid elongation. Am J Clin Exp Immunol 2023; 12: 107-108."},{"key":"ref11","doi-asserted-by":"publisher","first-page":"1781","DOI":"10.32604\/biocell.2024.055848","article-title":"Unveiling the predictive power of bacterial response-related genes signature in hepatocellular carcinoma: with bioinformatics analyses and experimental approaches","volume":"48","author":"Pourbagheri-Sigaroodi","year":"2024","unstructured":"Pourbagheri-Sigaroodi A, Momeny M, Rezaei N, Fallah F and Bashash D. Unveiling the predictive power of bacterial response-related genes signature in hepatocellular carcinoma: with bioinformatics analyses and experimental approaches. Biocell 2024; 48: 1781-1804.","journal-title":"Biocell"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"101241","DOI":"10.1016\/j.gendis.2024.101241","article-title":"Single-cell transcriptomic analysis of chondrocytes in cartilage and pathogenesis of osteoarthritis","volume":"12","author":"Huang","year":"2025","unstructured":"Huang C, Zeng B, Zhou B, Chen G, Zhang Q, Hou W, Xiao G, Duan L, Hong N and Jin W. Single-cell transcriptomic analysis of chondrocytes in cartilage and pathogenesis of osteoarthritis. Genes Dis 2025; 12: 101241.","journal-title":"Genes Dis"},{"key":"ref13","doi-asserted-by":"publisher","first-page":"116502","DOI":"10.1016\/j.ecoenv.2024.116502","article-title":"Triptolide exposure triggers testicular vacuolization injury by disrupting the Sertoli cell junction and cytoskeletal organization via the AKT\/mTOR signaling pathway","volume":"279","author":"Yang","year":"2024","unstructured":"Yang X, He L, Li X, Wang L, Bu T, Yun D, Lu X, Gao S, Huang Q, Li J, Zheng B, Yu J and Sun F. Triptolide exposure triggers testicular vacuolization injury by disrupting the Sertoli cell junction and cytoskeletal organization via the AKT\/mTOR signaling pathway. Ecotoxicol Environ Saf 2024; 279: 116502.","journal-title":"Ecotoxicol Environ Saf"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"114827","DOI":"10.1016\/j.ecoenv.2023.114827","article-title":"Gold nanoparticles retrogradely penetrate through testicular barriers via Sertoli-cells mediated endocytosis\/exocytosis and induce immune response in mouse","volume":"255","author":"Yu","year":"2023","unstructured":"Yu J, Xu J, Li H, Wu P, Zhu S, Huang X, Shen C, Zheng B and Li W. Gold nanoparticles retrogradely penetrate through testicular barriers via Sertoli-cells mediated endocytosis\/exocytosis and induce immune response in mouse. Ecotoxicol Environ Saf 2023; 255: 114827.","journal-title":"Ecotoxicol Environ Saf"},{"key":"ref15","doi-asserted-by":"publisher","first-page":"103484","DOI":"10.1016\/j.redox.2024.103484","article-title":"ASB1 engages with ELOB to facilitate SQOR ubiquitination and H(2)S homeostasis during spermiogenesis","volume":"79","author":"Lv","year":"2025","unstructured":"Lv J, Wu T, Xue J, Shen C, Gao W, Chen X, Guo Y, Liu M, Yu J, Huang X and Zheng B. ASB1 engages with ELOB to facilitate SQOR ubiquitination and H(2)S homeostasis during spermiogenesis. Redox Biol 2025; 79: 103484.","journal-title":"Redox Biol"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"1884","DOI":"10.1080\/15384101.2020.1779471","article-title":"BMI1 promotes steroidogenesis through maintaining redox homeostasis in mouse MLTC-1 and primary Leydig cells","volume":"19","author":"Gao","year":"2020","unstructured":"Gao T, Lin M, Shao B, Zhou Q, Wang Y, Chen X, Zhao D, Dai X, Shen C, Cheng H, Yang S, Li H, Zheng B, Zhong X, Yu J, Chen L and Huang X. BMI1 promotes steroidogenesis through maintaining redox homeostasis in mouse MLTC-1 and primary Leydig cells. Cell Cycle 2020; 19: 1884-1898.","journal-title":"Cell Cycle"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"2617","DOI":"10.32604\/biocell.2023.042476","article-title":"UCHL5 inhibits U251 glioma cell proliferation and tumor growth via stabilizing and deubiquitinating PTEN","volume":"47","author":"Xiao","year":"2023","unstructured":"Xiao Y, Ma W, Chen X, Hu W, Di Q, Zhao X, Huang G and Chen W. UCHL5 inhibits U251 glioma cell proliferation and tumor growth via stabilizing and deubiquitinating PTEN. Biocell 2023; 47: 2617-2625.","journal-title":"Biocell"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"100997","DOI":"10.1016\/j.gendis.2023.03.036","article-title":"The Traf2 and NcK interacting kinase inhibitor NCB-0846 suppresses seizure activity involving the decrease of GRIA1","volume":"11","author":"Wang","year":"2024","unstructured":"Wang M, Gu Y, Li Q, Feng B, Lv X, Zhang H, Kong Q, Dong Z, Tian X and Zhang Y. The Traf2 and NcK interacting kinase inhibitor NCB-0846 suppresses seizure activity involving the decrease of GRIA1. Genes Dis 2024; 11: 100997.","journal-title":"Genes Dis"},{"key":"ref19","doi-asserted-by":"publisher","first-page":"101266","DOI":"10.1016\/j.gendis.2024.101266","article-title":"VPS13D affects epileptic seizures by regulating mitochondrial fission and autophagy in epileptic rats","volume":"11","author":"Wang","year":"2024","unstructured":"Wang J, Zhang F, Luo Z, Zhang H, Yu C and Xu Z. VPS13D affects epileptic seizures by regulating mitochondrial fission and autophagy in epileptic rats. Genes Dis 2024; 11: 101266.","journal-title":"Genes Dis"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"169","DOI":"10.1017\/S0967199420000659","article-title":"Transferrin receptor (TFRC) is essential for meiotic progression during mouse spermatogenesis","volume":"29","author":"Gao","year":"2021","unstructured":"Gao T, Lin M, Wu Y, Li K, Liu C, Zhou Q, Shen C, Zheng B and Huang X. Transferrin receptor (TFRC) is essential for meiotic progression during mouse spermatogenesis. Zygote 2021; 29: 169-175.","journal-title":"Zygote"},{"key":"ref21","unstructured":"Wang J, Zhao J, Lin L, Peng X, Li W, Huang Y, Wang K and Li J. LncRNA-anrel promotes the proliferation and migration of synovial fibroblasts through regulating miR-146a-mediated annexin A1 expression. Am J Clin Exp Immunol 2023; 12: 49-59."},{"key":"ref22","doi-asserted-by":"publisher","first-page":"101283","DOI":"10.1016\/j.gendis.2024.101283","article-title":"Peritoneal adipose stem cell-derived extracellular vesicles mediate the regulation of ovarian cancer cell proliferation and migration through EGFR-NF-kappaB signaling","volume":"12","author":"Wang","year":"2025","unstructured":"Wang L, Luo N, Zhu J, Sulaiman Z, Yang W, Hu K, Ai G, Yang W, Shao X, Jin S, Zhang X, Fan Y, Deng D, Cheng Z and Gao Z. Peritoneal adipose stem cell-derived extracellular vesicles mediate the regulation of ovarian cancer cell proliferation and migration through EGFR-NF-kappaB signaling. Genes Dis 2025; 12: 101283.","journal-title":"Genes Dis"},{"key":"ref23","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1038\/s41422-018-0074-y","article-title":"Single-cell RNA-seq uncovers dynamic processes and critical regulators in mouse spermatogenesis","volume":"28","author":"Chen","year":"2018","unstructured":"Chen Y, Zheng Y, Gao Y, Lin Z, Yang S, Wang T, Wang Q, Xie N, Hua R, Liu M, Sha J, Griswold MD, Li J, Tang F and Tong MH. Single-cell RNA-seq uncovers dynamic processes and critical regulators in mouse spermatogenesis. Cell Res 2018; 28: 879-896.","journal-title":"Cell Res"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"1058","DOI":"10.3390\/cells11061058","article-title":"Ubiquitin-proteasome system-regulated protein degradation in spermatogenesis","volume":"11","author":"Xiong","year":"2022","unstructured":"Xiong Y, Yu C and Zhang Q. Ubiquitin-proteasome system-regulated protein degradation in spermatogenesis. Cells 2022; 11: 1058.","journal-title":"Cells"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1146\/annurev-biochem-060815-014922","article-title":"Ubiquitin ligases: structure, function, and regulation","volume":"86","author":"Zheng","year":"2017","unstructured":"Zheng N and Shabek N. Ubiquitin ligases: structure, function, and regulation. Annu Rev Biochem 2017; 86: 129-157.","journal-title":"Annu Rev Biochem"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"278","DOI":"10.1016\/j.ydbio.2011.01.028","article-title":"Cul4A is essential for spermatogenesis and male fertility","volume":"352","author":"Kopanja","year":"2011","unstructured":"Kopanja D, Roy N, Stoyanova T, Hess RA, Bagchi S and Raychaudhuri P. Cul4A is essential for spermatogenesis and male fertility. Dev Biol 2011; 352: 278-287.","journal-title":"Dev Biol"},{"key":"ref27","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1016\/j.apsb.2019.09.005","article-title":"Anticancer drug discovery by targeting cullin neddylation","volume":"10","author":"Yu","year":"2020","unstructured":"Yu Q, Jiang Y and Sun Y. Anticancer drug discovery by targeting cullin neddylation. Acta Pharm Sin B 2020; 10: 746-765.","journal-title":"Acta Pharm Sin B"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1016\/j.molmed.2024.05.005","article-title":"Ubiquitin-like modification dependent proteasomal degradation and disease therapy","volume":"30","author":"Wang","year":"2024","unstructured":"Wang T, Jiang J, Zhang X, Ke X and Qu Y. Ubiquitin-like modification dependent proteasomal degradation and disease therapy. Trends Mol Med 2024; 30: 1061-1075.","journal-title":"Trends Mol Med"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"167308","DOI":"10.1016\/j.bbadis.2024.167308","article-title":"DCUN1D1 and neddylation: potential targets for cancer therapy","volume":"1870","author":"Paccez","year":"2024","unstructured":"Paccez JD, Foret CLM, de Vasconcellos JF, Donaldson L and Zerbini LF. DCUN1D1 and neddylation: potential targets for cancer therapy. Biochim Biophys Acta Mol Basis Dis 2024; 1870: 167308.","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"1834","DOI":"10.62347\/STDA4237","article-title":"E3 ligase FBXO22 is not significant for spermatogenesis and male fertility in mice","volume":"16","author":"Wu","year":"2024","unstructured":"Wu T, Jin X, Huang C, Yu X, Xu B, Gao W, Qiu X, Bao M, Zhao D, Feng G, Zheng B and Huang X. E3 ligase FBXO22 is not significant for spermatogenesis and male fertility in mice. Am J Transl Res 2024; 16: 1834-1844.","journal-title":"Am J Transl Res"},{"key":"ref31","unstructured":"Wu Y, Zhang R, Shen C, Xu J, Wu T, Huang X, Liu M, Li H, Xu D and Zheng B. Testis-enriched Asb15 is not required for spermatogenesis and male fertility in mice. Am J Transl Res 2022; 14: 6978-6990."},{"key":"ref32","doi-asserted-by":"publisher","unstructured":"Meng Z, Qiao Y, Xue J, Wu T, Gao W, Huang X, Lv J, Liu M and Shen C. Slc26a1 is not essential for spermatogenesis and male fertility in mice. PeerJ 2023; 11: e16558.","DOI":"10.7717\/peerj.16558"}],"container-title":["American Journal of Clinical and Experimental Immunology"],"original-title":[],"link":[{"URL":"https:\/\/e-century.us\/files\/ajcei\/14\/3\/ajcei0163735.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T01:57:28Z","timestamp":1766023048000},"score":1,"resource":{"primary":{"URL":"https:\/\/e-century.us\/files\/ajcei\/14\/3\/ajcei0163735.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":33,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.62347\/bzpe6333","relation":{},"ISSN":["2164-7712"],"issn-type":[{"type":"electronic","value":"2164-7712"}],"subject":[],"published":{"date-parts":[[2025]]}}}