{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T21:49:02Z","timestamp":1787780942134,"version":"build-2784847793"},"reference-count":98,"publisher":"e-Century Publishing Corporation","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Cancer Res"],"DOI":"10.62347\/cutm4281","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T07:04:45Z","timestamp":1756451085000},"page":"3359-3375","source":"Crossref","is-referenced-by-count":4,"title":["Heterogeneity of monocytes in cancer"],"prefix":"10.62347","volume":"15","author":[{"given":"Xinyue","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"48694","published-online":{"date-parts":[[2025]]},"reference":[{"key":"ref0","doi-asserted-by":"publisher","unstructured":"Ziegler-Heitbrock L, Ancuta P, Crowe S, Dalod M, Grau V, Hart DN, Leenen PJ, Liu YJ, MacPherson G, Randolph GJ, Scherberich J, Schmitz J, Shortman K, Sozzani S, Strobl H, Zembala M, Austyn JM and Lutz MB. Nomenclature of monocytes and dendritic cells in blood. Blood 2010; 116: e74-80.","DOI":"10.1182\/blood-2010-02-258558"},{"key":"ref1","doi-asserted-by":"publisher","first-page":"762","DOI":"10.1038\/nri3070","article-title":"Monocyte recruitment during infection and inflammation","volume":"11","author":"Shi","year":"2011","unstructured":"Shi C and Pamer EG. Monocyte recruitment during infection and inflammation. Nat Rev Immunol 2011; 11: 762-774.","journal-title":"Nat Rev Immunol"},{"key":"ref2","doi-asserted-by":"publisher","unstructured":"Wong KL, Tai JJ, Wong WC, Han H, Sem X, Yeap WH, Kourilsky P and Wong SC. Gene expression profiling reveals the defining features of the classical, intermediate, and nonclassical human monocyte subsets. Blood 2011; 118: e16-31.","DOI":"10.1182\/blood-2010-12-326355"},{"key":"ref3","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1007\/s00281-013-0409-1","article-title":"From proliferation to proliferation: monocyte lineage comes full circle","volume":"36","author":"FK","year":"2014","unstructured":"Swirski FK, Hilgendorf I and Robbins CS. From proliferation to proliferation: monocyte lineage comes full circle. Semin Immunopathol 2014; 36: 137-148.","journal-title":"Semin Immunopathol"},{"key":"ref4","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1007\/s00281-013-0387-3","article-title":"Monocyte heterogeneity in cardiovascular disease","volume":"35","author":"Libby","year":"2013","unstructured":"Libby P, Nahrendorf M and Swirski FK. Monocyte heterogeneity in cardiovascular disease. Semin Immunopathol 2013; 35: 553-562.","journal-title":"Semin Immunopathol"},{"key":"ref5","doi-asserted-by":"publisher","unstructured":"Ingersoll MA, Spanbroek R, Lottaz C, Gautier EL, Frankenberger M, Hoffmann R, Lang R, Haniffa M, Collin M, Tacke F, Habenicht AJ, Ziegler-Heitbrock L and Randolph GJ. Comparison of gene expression profiles between human and mouse monocyte subsets. Blood 2010; 115: e10-19.","DOI":"10.1182\/blood-2009-07-235028"},{"key":"ref6","doi-asserted-by":"publisher","first-page":"41","DOI":"10.1007\/s12026-012-8297-3","article-title":"The three human monocyte subsets: implications for health and disease","volume":"53","author":"Wong","year":"2012","unstructured":"Wong KL, Yeap WH, Tai JJ, Ong SM, Dang TM and Wong SC. The three human monocyte subsets: implications for health and disease. Immunol Res 2012; 53: 41-57.","journal-title":"Immunol Res"},{"key":"ref7","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1016\/S1471-4906(03)00062-0","article-title":"Phagocyte-specific S100 proteins: a novel group of proinflammatory molecules","volume":"24","author":"Roth","year":"2003","unstructured":"Roth J, Vogl T, Sorg C and Sunderk&#xF6;tter C. Phagocyte-specific S100 proteins: a novel group of proinflammatory molecules. Trends Immunol 2003; 24: 155-158.","journal-title":"Trends Immunol"},{"key":"ref8","doi-asserted-by":"publisher","unstructured":"Zawada AM, Rogacev KS, Rotter B, Winter P, Marell RR, Fliser D and Heine GH. SuperSAGE evidence for CD14++CD16+ monocytes as a third monocyte subset. Blood 2011; 118: e50-61.","DOI":"10.1182\/blood-2011-01-326827"},{"key":"ref9","doi-asserted-by":"publisher","first-page":"104846","DOI":"10.1016\/j.ebiom.2023.104846","article-title":"Single-nucleus RNA sequencing reveals heterogenous microenvironments and specific drug response between cervical squamous cell carcinoma and adenocarcinoma","volume":"97","author":"Lin","year":"2023","unstructured":"Lin S, Sun Y, Cao C, Zhu Z, Xu Y, Liu B, Hu B, Peng T, Zhi W, Xu M, Ding W, Ren F, Ma D, Li G and Wu P. Single-nucleus RNA sequencing reveals heterogenous microenvironments and specific drug response between cervical squamous cell carcinoma and adenocarcinoma. EBioMedicine 2023; 97: 104846.","journal-title":"EBioMedicine"},{"key":"ref10","doi-asserted-by":"publisher","first-page":"6356","DOI":"10.3390\/ijms25126356","article-title":"Monocytic differentiation in acute myeloid leukemia cells: diagnostic criteria, biological heterogeneity, mitochondrial metabolism, resistance to and induction by targeted therapies","volume":"25","author":"&#xD8","year":"2024","unstructured":"Bruserud &#xD8;, Selheim F, Hernandez-Valladares M and Reikvam H. Monocytic differentiation in acute myeloid leukemia cells: diagnostic criteria, biological heterogeneity, mitochondrial metabolism, resistance to and induction by targeted therapies. Int J Mol Sci 2024; 25: 6356.","journal-title":"Int J Mol Sci"},{"key":"ref11","doi-asserted-by":"publisher","unstructured":"Liu L, Sun H, Feng F, Sun X, Ma J, Lv R, Yu T, Ye L, Li X, Yu Z, Zhang X, Jing H, Yao Y, Ma F, Qiu L and Hao M. Improving predictive accuracy in multiple myeloma using a plasma cell profile derived from single-cell RNA sequencing. Haematologica 2025; [Epub ahead of print].","DOI":"10.3324\/haematol.2025.287586"},{"key":"ref12","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.imlet.2020.07.007","article-title":"Plasticity of monocyte development and monocyte fates","volume":"227","author":"Trzebanski","year":"2020","unstructured":"Trzebanski S and Jung S. Plasticity of monocyte development and monocyte fates. Immunol Lett 2020; 227: 66-78.","journal-title":"Immunol Lett"},{"key":"ref13","doi-asserted-by":"publisher","unstructured":"Weinreb C, Rodriguez-Fraticelli A, Camargo FD and Klein AM. Lineage tracing on transcriptional landscapes links state to fate during differentiation. Science 2020; 367: eaaw3381.","DOI":"10.1126\/science.aaw3381"},{"key":"ref14","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1016\/j.immuni.2018.10.005","article-title":"Developmental and functional heterogeneity of monocytes","volume":"49","author":"Guilliams","year":"2018","unstructured":"Guilliams M, Mildner A and Yona S. Developmental and functional heterogeneity of monocytes. Immunity 2018; 49: 595-613.","journal-title":"Immunity"},{"key":"ref15","doi-asserted-by":"publisher","unstructured":"Y&#xE1;&#xF1;ez A, Coetzee SG, Olsson A, Muench DE, Berman BP, Hazelett DJ, Salomonis N, Grimes HL and Goodridge HS. Granulocyte-monocyte progenitors and monocyte-dendritic cell progenitors independently produce functionally distinct monocytes. Immunity 2017; 47: 890-902, e4.","DOI":"10.1016\/j.immuni.2017.10.021"},{"key":"ref16","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1038\/s41590-021-00871-y","article-title":"A RUNX-CBF&#x3B2;-driven enhancer directs the Irf8 dose-dependent lineage choice between DCs and monocytes","volume":"22","author":"Murakami","year":"2021","unstructured":"Murakami K, Sasaki H, Nishiyama A, Kurotaki D, Kawase W, Ban T, Nakabayashi J, Kanzaki S, Sekita Y, Nakajima H, Ozato K, Kimura T and Tamura T. A RUNX-CBF&#x3B2;-driven enhancer directs the Irf8 dose-dependent lineage choice between DCs and monocytes. Nat Immunol 2021; 22: 301-311.","journal-title":"Nat Immunol"},{"key":"ref17","doi-asserted-by":"publisher","first-page":"1450","DOI":"10.7150\/thno.87201","article-title":"Re-analysis of single-cell transcriptomics reveals a critical role of macrophage-like smooth muscle cells in advanced atherosclerotic plaque","volume":"14","author":"Gong","year":"2024","unstructured":"Gong X, Liu Y, Liu H, Cao N, Zeng L, Tian M, Zeng C, Hu Y, Zhang R, Chen Y and Wu G. Re-analysis of single-cell transcriptomics reveals a critical role of macrophage-like smooth muscle cells in advanced atherosclerotic plaque. Theranostics 2024; 14: 1450-1463.","journal-title":"Theranostics"},{"key":"ref18","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1093\/intimm\/dxx016","article-title":"Transcriptional control of monocyte and macrophage development","volume":"29","author":"Kurotaki","year":"2017","unstructured":"Kurotaki D, Sasaki H and Tamura T. Transcriptional control of monocyte and macrophage development. Int Immunol 2017; 29: 97-107.","journal-title":"Int Immunol"},{"key":"ref19","doi-asserted-by":"publisher","unstructured":"Deng Y, Wang H, Liu X, Yuan H, Xu J, de Th&#xE9; H, Zhou J and Zhu J. Zbtb14 regulates monocyte and macrophage development through inhibiting pu.1 expression in zebrafish. Elife 2022; 11: e80760.","DOI":"10.7554\/eLife.80760"},{"key":"ref20","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1038\/nature12026","article-title":"M-CSF instructs myeloid lineage fate in single haematopoietic stem cells","volume":"497","author":"Mossadegh-Keller","year":"2013","unstructured":"Mossadegh-Keller N, Sarrazin S, Kandalla PK, Espinosa L, Stanley ER, Nutt SL, Moore J and Sieweke MH. M-CSF instructs myeloid lineage fate in single haematopoietic stem cells. Nature 2013; 497: 239-243.","journal-title":"Nature"},{"key":"ref21","doi-asserted-by":"publisher","first-page":"108677","DOI":"10.1016\/j.clim.2021.108677","article-title":"Immunological features of circulating monocyte subsets in patients with squamous cell carcinoma of the head and neck","volume":"225","author":"Sakakura","year":"2021","unstructured":"Sakakura K, Takahashi H, Motegi SI, Yokobori-Kuwabara Y, Oyama T and Chikamatsu K. Immunological features of circulating monocyte subsets in patients with squamous cell carcinoma of the head and neck. Clin Immunol 2021; 225: 108677.","journal-title":"Clin Immunol"},{"key":"ref22","doi-asserted-by":"publisher","unstructured":"Zhang L, Wang Y, Yuan W, An C, Tan Q and Ma J. BEST1 Positive monocytes in circulation: visualize intratumoral crosstalk between cancer cells and monocytes. Adv Sci (Weinh) 2023; 10: e2205915.","DOI":"10.1002\/advs.202205915"},{"key":"ref23","doi-asserted-by":"publisher","unstructured":"Xie WH, Xiao WW, Chang H, Xu MJ, Hu YH, Zhou TC, Zhong Q, Chen CY, Lu LX, Wang QX, Zhu YJ, Yang J, Shi XY, Kang HL, Wei JW, Huang R, Peng HH, Yuan Y, Wu SH, Jiang XH, Liu YJ, Wen BX and Gao YH. Four cycles of docetaxel plus cisplatin as neoadjuvant chemotherapy followed by concurrent chemoradiotherapy in stage N2-3 nasopharyngeal carcinoma: phase 3 multicentre randomised controlled trial. BMJ 2025; 389: e081557.","DOI":"10.1136\/bmj-2024-081557"},{"key":"ref24","doi-asserted-by":"publisher","first-page":"2913","DOI":"10.1007\/s00405-019-05554-x","article-title":"Systemic immune response in squamous cell carcinoma of the head and neck: a comparative concordance index analysis","volume":"276","author":"Tham","year":"2019","unstructured":"Tham T, Wotman M, Chung C, Ahn S, Dupuis H, Gliagias V, Movsesova T, Kraus D and Costantino P. Systemic immune response in squamous cell carcinoma of the head and neck: a comparative concordance index analysis. Eur Arch Otorhinolaryngol 2019; 276: 2913-2922.","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"ref25","doi-asserted-by":"publisher","first-page":"3104","DOI":"10.7150\/thno.96163","article-title":"Single-cell analyses reveal evolution mimicry during the specification of breast cancer subtype","volume":"14","author":"Gao","year":"2024","unstructured":"Gao ZJ, Fang H, Sun S, Liu SQ, Fang Z, Liu Z, Li B, Wang P, Sun SR, Meng XY, Wu Q and Chen CS. Single-cell analyses reveal evolution mimicry during the specification of breast cancer subtype. Theranostics 2024; 14: 3104-3126.","journal-title":"Theranostics"},{"key":"ref26","doi-asserted-by":"publisher","first-page":"2910","DOI":"10.1182\/blood.V85.10.2910.bloodjournal85102910","article-title":"CD16+ monocytes in patients with cancer: spontaneous elevation and pharmacologic induction by recombinant human macrophage colony-stimulating factor","volume":"85","author":"Saleh","year":"1995","unstructured":"Saleh MN, Goldman SJ, LoBuglio AF, Beall AC, Sabio H, McCord MC, Minasian L, Alpaugh RK, Weiner LM and Munn DH. CD16+ monocytes in patients with cancer: spontaneous elevation and pharmacologic induction by recombinant human macrophage colony-stimulating factor. Blood 1995; 85: 2910-2917.","journal-title":"Blood"},{"key":"ref27","doi-asserted-by":"publisher","unstructured":"McGinnis CS, Miao Z, Superville D, Yao W, Goga A, Reticker-Flynn NE, Winkler J and Satpathy AT. The temporal progression of lung immune remodeling during breast cancer metastasis. Cancer Cell 2024; 42: 1018-1031, e6.","DOI":"10.1016\/j.ccell.2024.05.004"},{"key":"ref28","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1007\/s10549-017-4594-9","article-title":"CD14+ HLA-DR-\/low MDSCs are elevated in the periphery of early-stage breast cancer patients and suppress autologous T cell proliferation","volume":"168","author":"Speigl","year":"2018","unstructured":"Speigl L, Burow H, Bailur JK, Janssen N, Walter CB, Pawelec G and Shipp C. CD14+ HLA-DR-\/low MDSCs are elevated in the periphery of early-stage breast cancer patients and suppress autologous T cell proliferation. Breast Cancer Res Treat 2018; 168: 401-411.","journal-title":"Breast Cancer Res Treat"},{"key":"ref29","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1186\/s13287-021-02321-w","article-title":"Signaling pathways governing breast cancer stem cells behavior","volume":"12","author":"Song","year":"2021","unstructured":"Song K and Farzaneh M. Signaling pathways governing breast cancer stem cells behavior. Stem Cell Res Ther 2021; 12: 245.","journal-title":"Stem Cell Res Ther"},{"key":"ref30","doi-asserted-by":"publisher","first-page":"102631","DOI":"10.1016\/j.ebiom.2020.102631","article-title":"Breast cancer induces systemic immune changes on cytokine signaling in peripheral blood monocytes and lymphocytes","volume":"52","author":"Wang","year":"2020","unstructured":"Wang L, Simons DL, Lu X, Tu TY, Avalos C, Chang AY, Dirbas FM, Yim JH, Waisman J and Lee PP. Breast cancer induces systemic immune changes on cytokine signaling in peripheral blood monocytes and lymphocytes. EBioMedicine 2020; 52: 102631.","journal-title":"EBioMedicine"},{"key":"ref31","doi-asserted-by":"publisher","unstructured":"Zhang Y, Li H, Hao Y, Chen J, Chen X and Yin H. EGR2 O-GlcNAcylation orchestrates the development of protumoral macrophages to limit CD8(+) T cell antitumor responses. Cell Chem Biol 2025; 32: 809-825, e7.","DOI":"10.1016\/j.chembiol.2025.05.007"},{"key":"ref32","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.3389\/fimmu.2020.01413","article-title":"Peripheral blood classical monocytes and plasma interleukin 10 Are associated to neoadjuvant chemotherapy response in breast cancer patients","volume":"11","author":"Vald&#xE9","year":"2020","unstructured":"Vald&#xE9;s-Ferrada J, Mu&#xF1;oz-Durango N, P&#xE9;rez-Sepulveda A, Mu&#xF1;iz S, Coronado-Arr&#xE1;zola I, Acevedo F, Soto JA, Bueno SM, S&#xE1;nchez C and Kalergis AM. Peripheral blood classical monocytes and plasma interleukin 10 Are associated to neoadjuvant chemotherapy response in breast cancer patients. Front Immunol 2020; 11: 1413.","journal-title":"Front Immunol"},{"key":"ref33","doi-asserted-by":"publisher","unstructured":"Massa C, Karn T, Denkert C, Schneeweiss A, Hanusch C, Blohmer JU, Zahm DM, Jackisch C, van Mackelenbergh M, Thomalla J, Marme F, Huober J, M&#xFC;ller V, Schem C, Mueller A, Stickeler E, Biehl K, Fasching PA, Untch M, Loibl S, Weber K and Seliger B. Differential effect on different immune subsets of neoadjuvant chemotherapy in patients with TNBC. J Immunother Cancer 2020; 8: e001261.","DOI":"10.1136\/jitc-2020-001261"},{"key":"ref34","unstructured":"Arsenijevi&#x107; N, Baski&#x107; D, Popovi&#x107; S, Risti&#x107; P and A&#x107;imovi&#x107; L. Preliminary study of mononuclear phagocytosis during breast cancer therapy. J BUON 2005; 10: 105-109."},{"key":"ref35","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1007\/s00198-016-3807-0","article-title":"Increased CD14+ and decreased CD14- populations of monocytes 48 h after zolendronic acid infusion in breast cancer patients","volume":"28","author":"Kyrgidis","year":"2017","unstructured":"Kyrgidis A, Yavropoulou MP, Lagoudaki R, Andreadis C, Antoniades K and Kouvelas D. Increased CD14+ and decreased CD14- populations of monocytes 48 h after zolendronic acid infusion in breast cancer patients. Osteoporos Int 2017; 28: 991-999.","journal-title":"Osteoporos Int"},{"key":"ref36","doi-asserted-by":"publisher","unstructured":"Evren E, Ringqvist E, Tripathi KP, Sleiers N, Rives IC, Alisjahbana A, Gao Y, Sarhan D, Halle T, Sorini C, Lepzien R, Marquardt N, Micha&#xEB;lsson J, Smed-S&#xF6;rensen A, Botling J, Karlsson MCI, Villablanca EJ and Willinger T. Distinct developmental pathways from blood monocytes generate human lung macrophage diversity. Immunity 2021; 54: 259-275, e7.","DOI":"10.1016\/j.immuni.2020.12.003"},{"key":"ref37","doi-asserted-by":"publisher","first-page":"2513","DOI":"10.3390\/cancers12092513","article-title":"Blood monocyte subsets with activation markers in relation with macrophages in non-small cell lung cancer","volume":"12","author":"Kwiecie&#x144","year":"2020","unstructured":"Kwiecie&#x144; I, Rutkowska E, Polubiec-Kownacka M, Raniszewska A, Rzepecki P and Domaga&#x142;a-Kulawik J. Blood monocyte subsets with activation markers in relation with macrophages in non-small cell lung cancer. Cancers (Basel) 2020; 12: 2513.","journal-title":"Cancers (Basel)"},{"key":"ref38","doi-asserted-by":"publisher","unstructured":"Kim GD, Shin SI, Sun P, Lee JE, Chung C, Kang YE, Kang DH and Park J. Single-cell RNA sequencing of baseline PBMCs predicts ICI efficacy and irAE severity in patients with NSCLC. J Immunother Cancer 2025; 13: e011636.","DOI":"10.1136\/jitc-2025-011636"},{"key":"ref39","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1080\/08820139.2022.2130075","article-title":"The Interleukin-33\/ST2 axis enhances lung-resident CD14+ monocyte function in patients with non-small cell lung cancer","volume":"52","author":"Wang","year":"2023","unstructured":"Wang L, Mei X, Liu X, Guo L, Yang B and Chen R. The Interleukin-33\/ST2 axis enhances lung-resident CD14+ monocyte function in patients with non-small cell lung cancer. Immunol Invest 2023; 52: 67-82.","journal-title":"Immunol Invest"},{"key":"ref40","doi-asserted-by":"publisher","first-page":"3589","DOI":"10.21037\/tcr-24-10","article-title":"Monocytes-to-lymphocytes ratio increases the prognostic value of circulating tumor cells in non-small cell lung cancer: a prospective study","volume":"13","author":"Huangfu","year":"2024","unstructured":"Huangfu Y, Chang F, Zhang F, Jiao Y and Han L. Monocytes-to-lymphocytes ratio increases the prognostic value of circulating tumor cells in non-small cell lung cancer: a prospective study. Transl Cancer Res 2024; 13: 3589-3598.","journal-title":"Transl Cancer Res"},{"key":"ref41","doi-asserted-by":"publisher","first-page":"1519","DOI":"10.1002\/ijc.33381","article-title":"Tie2-expressing monocytes as a novel angiogenesis-related cellular biomarker for non-small cell lung cancer","volume":"148","author":"Xue","year":"2021","unstructured":"Xue R, Sheng Y, Duan X, Yang Y, Ma S, Xu J, Wei N, Shang X, Li F, Wan J and Qin Z. Tie2-expressing monocytes as a novel angiogenesis-related cellular biomarker for non-small cell lung cancer. Int J Cancer 2021; 148: 1519-1528.","journal-title":"Int J Cancer"},{"key":"ref42","doi-asserted-by":"publisher","first-page":"1988","DOI":"10.1038\/s41467-018-04355-w","article-title":"Factor XIIIA-expressing inflammatory monocytes promote lung squamous cancer through fibrin cross-linking","volume":"9","author":"Porrello","year":"2018","unstructured":"Porrello A, Leslie PL, Harrison EB, Gorentla BK, Kattula S, Ghosh SK, Azam SH, Holtzhausen A, Chao YL, Hayward MC, Waugh TA, Bae S, Godfrey V, Randell SH, Oderup C, Makowski L, Weiss J, Wilkerson MD, Hayes DN, Earp HS, Baldwin AS, Wolberg AS and Pecot CV. Factor XIIIA-expressing inflammatory monocytes promote lung squamous cancer through fibrin cross-linking. Nat Commun 2018; 9: 1988.","journal-title":"Nat Commun"},{"key":"ref43","doi-asserted-by":"publisher","first-page":"1345","DOI":"10.1038\/s41467-025-56546-x","article-title":"Spatially mapping the tumour immune microenvironments of non-small cell lung cancer","volume":"16","author":"Desharnais","year":"2025","unstructured":"Desharnais L, Sorin M, Rezanejad M, Liu B, Karimi E, Atallah A, Swaby AM, Yu MW, Dor&#xE9; S, Hartner S, Fiset B, Wei Y, Kadang B, Rayes R, Joubert P, Camilleri-Bro&#xEB;t S, Fiset PO, Quail DF, Spicer JD and Walsh LA. Spatially mapping the tumour immune microenvironments of non-small cell lung cancer. Nat Commun 2025; 16: 1345.","journal-title":"Nat Commun"},{"key":"ref44","doi-asserted-by":"publisher","first-page":"2547","DOI":"10.1007\/s00262-020-02639-z","article-title":"Increased IL-10+CD206+CD14+M2-like macrophages in alveolar lavage fluid of patients with small cell lung cancer","volume":"69","author":"Hu","year":"2020","unstructured":"Hu X, Gu Y, Zhao S, Hua S and Jiang Y. Increased IL-10+CD206+CD14+M2-like macrophages in alveolar lavage fluid of patients with small cell lung cancer. Cancer Immunol Immunother 2020; 69: 2547-2560.","journal-title":"Cancer Immunol Immunother"},{"key":"ref45","doi-asserted-by":"publisher","first-page":"1533033818764720","DOI":"10.1177\/1533033818764720","article-title":"Restoration of peripheral intermediate and classical monocytes expressing HLA-DR in patients with lung adenocarcinoma after platinum-based chemotherapy","volume":"17","author":"Rivas-Fuentes S","year":"2018","unstructured":"Rivas-Fuentes S, Iglesias AH, Trejo AG, Castro DYC, Figueroa NI, P&#xE9;rez TA, Salda&#xF1;a RB and Rosete PG. Restoration of peripheral intermediate and classical monocytes expressing HLA-DR in patients with lung adenocarcinoma after platinum-based chemotherapy. Technol Cancer Res Treat 2018; 17: 1533033818764720.","journal-title":"Technol Cancer Res Treat"},{"key":"ref46","doi-asserted-by":"publisher","first-page":"5925","DOI":"10.3390\/ijms21165925","article-title":"CD163 as a biomarker in colorectal cancer: the expression on circulating monocytes and tumor-associated macrophages, and the soluble form in the blood","volume":"21","author":"Krijgsman","year":"2020","unstructured":"Krijgsman D, De Vries NL, Andersen MN, Skovbo A, Tollenaar RAEM, M&#xF8;ller HJ, Hokland M and Kuppen PJK. CD163 as a biomarker in colorectal cancer: the expression on circulating monocytes and tumor-associated macrophages, and the soluble form in the blood. Int J Mol Sci 2020; 21: 5925.","journal-title":"Int J Mol Sci"},{"key":"ref47","doi-asserted-by":"publisher","unstructured":"Wang F, Long J, Li L, Wu ZX, Da TT, Wang XQ, Huang C, Jiang YH, Yao XQ, Ma HQ, Lian ZX, Zhao ZB and Cao J. Single-cell and spatial transcriptome analysis reveals the cellular heterogeneity of liver metastatic colorectal cancer. Sci Adv 2023; 9: eadf5464.","DOI":"10.1126\/sciadv.adf5464"},{"key":"ref48","doi-asserted-by":"publisher","unstructured":"Li C, Luo X, Lin Y, Tang X, Ling L, Wang L and Jiang Y. A higher frequency of CD14+ CD169+ monocytes\/macrophages in patients with colorectal cancer. PLoS One 2015; 10: e0141817.","DOI":"10.1371\/journal.pone.0141817"},{"key":"ref49","doi-asserted-by":"publisher","unstructured":"Fernandez M, Todeschini L, Keenan BP, Rosenberg D, Hernandez S, Zampese M, Qiao G, Pollini T and Maker AV. Novel computational analysis identifies cytotoxic lymphocyte-to-monocyte balance in tumors as a predictor of recurrence-free survival in colorectal carcinoma. Ann Surg Oncol 2025; [Epub ahead of print].","DOI":"10.1245\/s10434-025-17599-w"},{"key":"ref50","doi-asserted-by":"publisher","first-page":"1953","DOI":"10.1111\/cns.14152","article-title":"Monocyte to high-density lipoprotein ratio predicts clinical outcomes after acute ischemic stroke or transient ischemic attack","volume":"29","author":"Xu","year":"2023","unstructured":"Xu Q, Wu Q, Chen L, Li H, Tian X, Xia X, Zhang Y, Zhang X, Lin Y, Wu Y, Wang Y, Meng X and Wang A. Monocyte to high-density lipoprotein ratio predicts clinical outcomes after acute ischemic stroke or transient ischemic attack. CNS Neurosci Ther 2023; 29: 1953-1964.","journal-title":"CNS Neurosci Ther"},{"key":"ref51","doi-asserted-by":"publisher","first-page":"740","DOI":"10.1186\/s12885-024-12509-x","article-title":"Nomogram incorporating preoperative pan-immune-inflammation value and monocyte to high-density lipoprotein ratio for survival prediction in patients with colorectal cancer: a retrospective study","volume":"24","author":"Liu","year":"2024","unstructured":"Liu Q, Wang H, Chen Q, Luo R and Luo C. Nomogram incorporating preoperative pan-immune-inflammation value and monocyte to high-density lipoprotein ratio for survival prediction in patients with colorectal cancer: a retrospective study. BMC Cancer 2024; 24: 740.","journal-title":"BMC Cancer"},{"key":"ref52","doi-asserted-by":"publisher","unstructured":"V&#xE4;yrynen JP, Haruki K, V&#xE4;yrynen SA, Lau MC, Dias Costa A, Borowsky J, Zhao M, Ugai T, Kishikawa J, Akimoto N, Zhong R, Shi S, Chang TW, Fujiyoshi K, Arima K, Twombly TS, Da Silva A, Song M, Wu K, Zhang X, Chan AT, Nishihara R, Fuchs CS, Meyerhardt JA, Giannakis M, Ogino S and Nowak JA. Prognostic significance of myeloid immune cells and their spatial distribution in the colorectal cancer microenvironment. J Immunother Cancer 2021; 9: e002297.","DOI":"10.1136\/jitc-2020-002297"},{"key":"ref53","doi-asserted-by":"publisher","first-page":"647","DOI":"10.4049\/immunohorizons.2000017","article-title":"Extracellular vesicles secreted by tumor cells promote the generation of suppressive monocytes","volume":"5","author":"Luong","year":"2021","unstructured":"Luong N, Lenz JA, Modiano JF and Olson JK. Extracellular vesicles secreted by tumor cells promote the generation of suppressive monocytes. Immunohorizons 2021; 5: 647-658.","journal-title":"Immunohorizons"},{"key":"ref54","doi-asserted-by":"publisher","first-page":"695","DOI":"10.1158\/0008-5472.CAN-13-0946","article-title":"Metastatic growth progression caused by PSGL-1-mediated recruitment of monocytes to metastatic sites","volume":"74","author":"Hoos","year":"2014","unstructured":"Hoos A, Protsyuk D and Borsig L. Metastatic growth progression caused by PSGL-1-mediated recruitment of monocytes to metastatic sites. Cancer Res 2014; 74: 695-704.","journal-title":"Cancer Res"},{"key":"ref55","doi-asserted-by":"publisher","first-page":"3039","DOI":"10.1172\/JCI93182","article-title":"Ly6Clo monocytes drive immunosuppression and confer resistance to anti-VEGFR2 cancer therapy","volume":"127","author":"Jung","year":"2017","unstructured":"Jung K, Heishi T, Khan OF, Kowalski PS, Incio J, Rahbari NN, Chung E, Clark JW, Willett CG, Luster AD, Yun SH, Langer R, Anderson DG, Padera TP, Jain RK and Fukumura D. Ly6Clo monocytes drive immunosuppression and confer resistance to anti-VEGFR2 cancer therapy. J Clin Invest 2017; 127: 3039-3051.","journal-title":"J Clin Invest"},{"key":"ref56","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.ijsu.2018.05.030","article-title":"Prognostic significance of lymphocyte to monocyte ratio in colorectal cancer: a meta-analysis","volume":"55","author":"Tan","year":"2018","unstructured":"Tan D, Fu Y, Tong W and Li F. Prognostic significance of lymphocyte to monocyte ratio in colorectal cancer: a meta-analysis. Int J Surg 2018; 55: 128-138.","journal-title":"Int J Surg"},{"key":"ref57","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1182\/blood-2007-01-068031","article-title":"Tumor-derived hyaluronan induces formation of immunosuppressive macrophages through transient early activation of monocytes","volume":"110","author":"Kuang","year":"2007","unstructured":"Kuang DM, Wu Y, Chen N, Cheng J, Zhuang SM and Zheng L. Tumor-derived hyaluronan induces formation of immunosuppressive macrophages through transient early activation of monocytes. Blood 2007; 110: 587-595.","journal-title":"Blood"},{"key":"ref58","doi-asserted-by":"publisher","first-page":"983","DOI":"10.1136\/gutjnl-2024-334026","article-title":"Multiomics analysis of immune correlatives in hepatocellular carcinoma patients treated with tremelimumab plus durvalumab","volume":"74","author":"Myojin","year":"2025","unstructured":"Myojin Y, Babaei S, Trehan R, Hoffman C, Kedei N, Ruf B, Benmebarek MR, Bauer KC, Huang P, Ma C, Monge C, Xie C, Hrones D, Duffy AG, Armstrong P, Kocheise L, Desmond F, Buchalter J, Galligan M, Cantwell C, Ryan R, McCann J, Bourke M, Mac Nicholas R, McDermott R, Awosika J, Cam M, Krebs R, Budhu A, Revsine M, Figg WD, Kleiner DE, Redd B, Wood BJ, Wang XW, Korangy F, Claassen M and Greten TF. Multiomics analysis of immune correlatives in hepatocellular carcinoma patients treated with tremelimumab plus durvalumab. Gut 2025; 74: 983-995.","journal-title":"Gut"},{"key":"ref59","doi-asserted-by":"publisher","first-page":"906","DOI":"10.1016\/j.jhep.2020.05.004","article-title":"Glycolytic activation of monocytes regulates the accumulation and function of neutrophils in human hepatocellular carcinoma","volume":"73","author":"Peng","year":"2020","unstructured":"Peng ZP, Jiang ZZ, Guo HF, Zhou MM, Huang YF, Ning WR, Huang JH, Zheng L and Wu Y. Glycolytic activation of monocytes regulates the accumulation and function of neutrophils in human hepatocellular carcinoma. J Hepatol 2020; 73: 906-917.","journal-title":"J Hepatol"},{"key":"ref60","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1002\/hep.30134","article-title":"CCL15 Recruits suppressive monocytes to facilitate immune escape and disease progression in hepatocellular carcinoma","volume":"69","author":"Liu","year":"2019","unstructured":"Liu LZ, Zhang Z, Zheng BH, Shi Y, Duan M, Ma LJ, Wang ZC, Dong LQ, Dong PP, Shi JY, Zhang S, Ding ZB, Ke AW, Cao Y, Zhang XM, Xi R, Zhou J, Fan J, Wang XY and Gao Q. CCL15 Recruits suppressive monocytes to facilitate immune escape and disease progression in hepatocellular carcinoma. Hepatology 2019; 69: 143-159.","journal-title":"Hepatology"},{"key":"ref61","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1186\/s13046-024-02985-1","article-title":"S100A9(+)CD14(+) monocytes contribute to anti-PD-1 immunotherapy resistance in advanced hepatocellular carcinoma by attenuating T cell-mediated antitumor function","volume":"43","author":"Tu","year":"2024","unstructured":"Tu X, Chen L, Zheng Y, Mu C, Zhang Z, Wang F, Ren Y, Duan Y, Zhang H, Tong Z, Liu L, Sun X, Zhao P, Wang L, Feng X, Fang W and Liu X. S100A9(+)CD14(+) monocytes contribute to anti-PD-1 immunotherapy resistance in advanced hepatocellular carcinoma by attenuating T cell-mediated antitumor function. J Exp Clin Cancer Res 2024; 43: 72.","journal-title":"J Exp Clin Cancer Res"},{"key":"ref62","doi-asserted-by":"publisher","first-page":"436","DOI":"10.1007\/s12026-020-09155-3","article-title":"PD-1 expression is elevated in monocytes from hepatocellular carcinoma patients and contributes to CD8 T cell suppression","volume":"68","author":"Yun","year":"2020","unstructured":"Yun J, Yu G, Hu P, Chao Y, Li X, Chen X, Wei Q and Wang J. PD-1 expression is elevated in monocytes from hepatocellular carcinoma patients and contributes to CD8 T cell suppression. Immunol Res 2020; 68: 436-444.","journal-title":"Immunol Res"},{"key":"ref63","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1016\/j.jhep.2019.04.007","article-title":"Glycolytic activation of peritumoral monocytes fosters immune privilege via the PFKFB3-PD-L1 axis in human hepatocellular carcinoma","volume":"71","author":"Chen","year":"2019","unstructured":"Chen DP, Ning WR, Jiang ZZ, Peng ZP, Zhu LY, Zhuang SM, Kuang DM, Zheng L and Wu Y. Glycolytic activation of peritumoral monocytes fosters immune privilege via the PFKFB3-PD-L1 axis in human hepatocellular carcinoma. J Hepatol 2019; 71: 333-343.","journal-title":"J Hepatol"},{"key":"ref64","doi-asserted-by":"publisher","first-page":"10377","DOI":"10.1038\/s41598-020-67497-2","article-title":"Increased both PD-L1 and PD-L2 expressions on monocytes of patients with hepatocellular carcinoma was associated with a poor prognosis","volume":"10","author":"Yasuoka","year":"2020","unstructured":"Yasuoka H, Asai A, Ohama H, Tsuchimoto Y, Fukunishi S and Higuchi K. Increased both PD-L1 and PD-L2 expressions on monocytes of patients with hepatocellular carcinoma was associated with a poor prognosis. Sci Rep 2020; 10: 10377.","journal-title":"Sci Rep"},{"key":"ref65","doi-asserted-by":"publisher","unstructured":"Chang JQ, Guo Y, Yuan WJ, Chen YM, Liu BW, Li WT, Ding XM, Fu XD, Lou YH, Chen ZR, Luo XY, Ding SZ, Zhang BY, Li XL, Hong YZ, Cang SD, Li DX and Lan L. HLA-DR+ tumor cells show an association with a distinct immune microenvironment and CD8+ T-Cell exhaustion in HBV-associated hepatocellular carcinoma. Adv Sci (Weinh) 2025; e02979.","DOI":"10.1002\/advs.202502979"},{"key":"ref66","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1016\/j.tips.2018.10.008","article-title":"MDSC; The most important cell you have never heard of","volume":"40","author":"Tesi","year":"2019","unstructured":"Tesi RJ. MDSC; The most important cell you have never heard of. Trends Pharmacol Sci 2019; 40: 4-7.","journal-title":"Trends Pharmacol Sci"},{"key":"ref67","doi-asserted-by":"publisher","first-page":"1061","DOI":"10.1111\/hepr.12831","article-title":"Circulating CD14(+) HLA-DR(-\/low) myeloid-derived suppressor cells predicted early recurrence of hepatocellular carcinoma after surgery","volume":"47","author":"Gao","year":"2017","unstructured":"Gao XH, Tian L, Wu J, Ma XL, Zhang CY, Zhou Y, Sun YF, Hu B, Qiu SJ, Zhou J, Fan J, Guo W and Yang XR. Circulating CD14(+) HLA-DR(-\/low) myeloid-derived suppressor cells predicted early recurrence of hepatocellular carcinoma after surgery. Hepatol Res 2017; 47: 1061-1071.","journal-title":"Hepatol Res"},{"key":"ref68","doi-asserted-by":"publisher","first-page":"10427","DOI":"10.1007\/s13277-016-4916-2","article-title":"The clinical and prognostic significance of CD14(+)HLA-DR(-\/low) myeloid-derived suppressor cells in hepatocellular carcinoma patients receiving radiotherapy","volume":"37","author":"Wang","year":"2016","unstructured":"Wang D, An G, Xie S, Yao Y and Feng G. The clinical and prognostic significance of CD14(+)HLA-DR(-\/low) myeloid-derived suppressor cells in hepatocellular carcinoma patients receiving radiotherapy. Tumour Biol 2016; 37: 10427-10433.","journal-title":"Tumour Biol"},{"key":"ref69","doi-asserted-by":"publisher","first-page":"101087","DOI":"10.1016\/j.jhepr.2024.101087","article-title":"PPP1R15A-expressing monocytic MDSCs promote immunosuppressive liver microenvironment in fibrosis-associated hepatocellular carcinoma","volume":"6","author":"Liu","year":"2024","unstructured":"Liu X, Liu M, Wu H, Tang W, Yang W, Chan TTH, Zhang L, Chen S, Xiong Z, Liang J, Wai-Yiu Si-Tou W, Shu T, Li J, Cao J, Zhong C, Sun H, Kwong TT, Leung HHW, Wong J, Bo-San Lai P, To KF, Xiang T, Jao-Yiu Sung J, Chan SL, Zhou J and Sze-Lok Cheng A. PPP1R15A-expressing monocytic MDSCs promote immunosuppressive liver microenvironment in fibrosis-associated hepatocellular carcinoma. JHEP Rep 2024; 6: 101087.","journal-title":"JHEP Rep"},{"key":"ref70","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1158\/2326-6066.CIR-13-0094","article-title":"Untreated stage IV melanoma patients exhibit abnormal monocyte phenotypes and decreased functional capacity","volume":"2","author":"Chavan","year":"2014","unstructured":"Chavan R, Salvador D, Gustafson MP, Dietz AB, Nevala W and Markovic SN. Untreated stage IV melanoma patients exhibit abnormal monocyte phenotypes and decreased functional capacity. Cancer Immunol Res 2014; 2: 241-248.","journal-title":"Cancer Immunol Res"},{"key":"ref71","doi-asserted-by":"publisher","first-page":"1808424","DOI":"10.1080\/2162402X.2020.1808424","article-title":"Human innate immune cell crosstalk induces melanoma cell senescence","volume":"9","author":"Funck","year":"2020","unstructured":"Funck F, Pahl J, Kyjacova L, Freund L, Oehrl S, Gr&#xE4;be G, Pezer S, Hassel JC, Sleeman J, Cerwenka A and Sch&#xE4;kel K. Human innate immune cell crosstalk induces melanoma cell senescence. Oncoimmunology 2020; 9: 1808424.","journal-title":"Oncoimmunology"},{"key":"ref72","doi-asserted-by":"publisher","first-page":"13085","DOI":"10.1073\/pnas.1300314110","article-title":"Inflammatory monocytes are potent antitumor effectors controlled by regulatory CD4+ T cells","volume":"110","author":"Pommier","year":"2013","unstructured":"Pommier A, Audemard A, Durand A, Lengagne R, Delpoux A, Martin B, Douguet L, Le Campion A, Kato M, Avril MF, Auffray C, Lucas B and Pr&#xE9;vost-Blondel A. Inflammatory monocytes are potent antitumor effectors controlled by regulatory CD4+ T cells. Proc Natl Acad Sci U S A 2013; 110: 13085-13090.","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref73","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1038\/nm.4466","article-title":"High-dimensional single-cell analysis predicts response to anti-PD-1 immunotherapy","volume":"24","author":"Krieg","year":"2018","unstructured":"Krieg C, Nowicka M, Guglietta S, Schindler S, Hartmann FJ, Weber LM, Dummer R, Robinson MD, Levesque MP and Becher B. High-dimensional single-cell analysis predicts response to anti-PD-1 immunotherapy. Nat Med 2018; 24: 144-153.","journal-title":"Nat Med"},{"key":"ref74","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1186\/s12943-024-01936-w","article-title":"Targeted deletion of CD244 on monocytes promotes differentiation into anti-tumorigenic macrophages and potentiates PD-L1 blockade in melanoma","volume":"23","author":"Kim","year":"2024","unstructured":"Kim J, Kim TJ, Chae S, Ha H, Park Y, Park S, Yoon CJ, Lim SA, Lee H, Kim J, Kim J, Im K, Lee K, Kim J, Kim D, Lee E, Shin MH, Park SI, Rhee I, Jung K, Lee J, Lee KH, Hwang D and Lee KM. Targeted deletion of CD244 on monocytes promotes differentiation into anti-tumorigenic macrophages and potentiates PD-L1 blockade in melanoma. Mol Cancer 2024; 23: 45.","journal-title":"Mol Cancer"},{"key":"ref75","doi-asserted-by":"publisher","first-page":"5505","DOI":"10.1172\/JCI98060","article-title":"Tumor-derived microRNAs induce myeloid suppressor cells and predict immunotherapy resistance in melanoma","volume":"128","author":"Huber","year":"2018","unstructured":"Huber V, Vallacchi V, Fleming V, Hu X, Cova A, Dugo M, Shahaj E, Sulsenti R, Vergani E, Filipazzi P, De Laurentiis A, Lalli L, Di Guardo L, Patuzzo R, Vergani B, Casiraghi E, Cossa M, Gualeni A, Bollati V, Arienti F, De Braud F, Mariani L, Villa A, Altevogt P, Umansky V, Rodolfo M and Rivoltini L. Tumor-derived microRNAs induce myeloid suppressor cells and predict immunotherapy resistance in melanoma. J Clin Invest 2018; 128: 5505-5516.","journal-title":"J Clin Invest"},{"key":"ref76","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1007\/s00262-019-02476-9","article-title":"High expression of ID1 in monocytes is strongly associated with phenotypic and functional MDSC markers in advanced melanoma","volume":"69","author":"Melief","year":"2020","unstructured":"Melief J, Pico de Coa&#xF1;a Y, Maas R, Fennemann FL, Wolodarski M, Hansson J and Kiessling R. High expression of ID1 in monocytes is strongly associated with phenotypic and functional MDSC markers in advanced melanoma. Cancer Immunol Immunother 2020; 69: 513-522.","journal-title":"Cancer Immunol Immunother"},{"key":"ref77","doi-asserted-by":"publisher","unstructured":"Sharma MD, Rodriguez PC, Koehn BH, Baban B, Cui Y, Guo G, Shimoda M, Pacholczyk R, Shi H, Lee EJ, Xu H, Johnson TS, He Y, Mergoub T, Venable C, Bronte V, Wolchok JD, Blazar BR and Munn DH. Activation of p53 in immature myeloid precursor cells controls differentiation into Ly6c(+)CD103(+) monocytic antigen-presenting cells in tumors. Immunity 2018; 48: 91-106, e6.","DOI":"10.1016\/j.immuni.2017.12.014"},{"key":"ref78","doi-asserted-by":"publisher","first-page":"716","DOI":"10.1038\/s41586-024-08257-4","article-title":"Cancer cells impair monocyte-mediated T cell stimulation to evade immunity","volume":"637","author":"Elewaut","year":"2025","unstructured":"Elewaut A, Estivill G, Bayerl F, Castillon L, Novatchkova M, Pottendorfer E, Hoffmann-Haas L, Sch&#xF6;nlein M, Nguyen TV, Lauss M, Andreatta F, Vulin M, Krecioch I, Bayerl J, Pedde AM, Fabre N, Holstein F, Cronin SM, Rieser S, Laniti DD, Barras D, Coukos G, Quek C, Bai X, Mu&#xF1;oz I Ordo&#xF1;o M, Wiesner T, Zuber J, J&#xF6;nsson G, B&#xF6;ttcher JP, Vanharanta S and Obenauf AC. Cancer cells impair monocyte-mediated T cell stimulation to evade immunity. Nature 2025; 637: 716-725.","journal-title":"Nature"},{"key":"ref79","doi-asserted-by":"publisher","unstructured":"Zhao S, Ye B, Chi H, Cheng C and Liu J. Identification of peripheral blood immune infiltration signatures and construction of monocyte-associated signatures in ovarian cancer and Alzheimer&#x2019;s disease using single-cell sequencing. Heliyon 2023; 9: e17454.","DOI":"10.1016\/j.heliyon.2023.e17454"},{"key":"ref80","doi-asserted-by":"publisher","unstructured":"Prat M, Le Naour A, Coulson K, Lem&#xE9;e F, Leray H, Jacquemin G, Rahabi MC, Lemaitre L, Authier H, Ferron G, Barret JM, Martinez A, Ayyoub M, Delord JP, Gladieff L, Tabah-Fisch I, Prost JF, Couderc B and Coste A. Circulating CD14(high) CD16(low) intermediate blood monocytes as a biomarker of ascites immune status and ovarian cancer progression. J Immunother Cancer 2020; 8: e000472.","DOI":"10.1136\/jitc-2019-000472"},{"key":"ref81","doi-asserted-by":"publisher","first-page":"1371","DOI":"10.1038\/bjc.2017.297","article-title":"Crosstalk between TEMs and endothelial cells modulates angiogenesis and metastasis via IGF1-IGF1R signalling in epithelial ovarian cancer","volume":"117","author":"Wang","year":"2017","unstructured":"Wang X, Zhu Q, Lin Y, Wu L, Wu X, Wang K, He Q, Xu C, Wan X and Wang X. Crosstalk between TEMs and endothelial cells modulates angiogenesis and metastasis via IGF1-IGF1R signalling in epithelial ovarian cancer. Br J Cancer 2017; 117: 1371-1382.","journal-title":"Br J Cancer"},{"key":"ref82","doi-asserted-by":"publisher","unstructured":"Stenzel AE, Abrams SI, Joseph JM, Goode EL, Tario JD Jr, Wallace PK, Kaur D, Adamson AK, Buas MF, Lugade AA, Laslavic A, Taylor SE, Orr B, Edwards RP, Elishaev E, Odunsi K, Mongiovi JM, Etter JL, Winham SJ, Kaufmann SH, Modugno F and Moysich KB. Circulating CD14(+) HLA-DR(lo\/-) monocytic cells as a biomarker for epithelial ovarian cancer progression. Am J Reprod Immunol 2021; 85: e13343.","DOI":"10.1111\/aji.13343"},{"key":"ref83","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1111\/jop.12760","article-title":"Frequency of circulating CD14(++) CD16(+) intermediate monocytes as potential biomarker for the diagnosis of oral squamous cell carcinoma","volume":"47","author":"Song","year":"2018","unstructured":"Song Y, Zhou Q, Zhu H, Jing Y, Zhang X, Yang Y, Hu Q, Huang X and Ni Y. Frequency of circulating CD14(++) CD16(+) intermediate monocytes as potential biomarker for the diagnosis of oral squamous cell carcinoma. J Oral Pathol Med 2018; 47: 923-929.","journal-title":"J Oral Pathol Med"},{"key":"ref84","doi-asserted-by":"publisher","first-page":"3404","DOI":"10.1158\/1078-0432.CCR-13-0525","article-title":"Inflammatory monocyte mobilization decreases patient survival in pancreatic cancer: a role for targeting the CCL2\/CCR2 axis","volume":"19","author":"Sanford","year":"2013","unstructured":"Sanford DE, Belt BA, Panni RZ, Mayer A, Deshpande AD, Carpenter D, Mitchem JB, Plambeck-Suess SM, Worley LA, Goetz BD, Wang-Gillam A, Eberlein TJ, Denardo DG, Goedegebuure SP and Linehan DC. Inflammatory monocyte mobilization decreases patient survival in pancreatic cancer: a role for targeting the CCL2\/CCR2 axis. Clin Cancer Res 2013; 19: 3404-3415.","journal-title":"Clin Cancer Res"},{"key":"ref85","unstructured":"Baj-Krzyworzeka M, Baran J, Weglarczyk K, Szatanek R, Szaflarska A, Siedlar M and Zembala M. Tumour-derived microvesicles (TMV) mimic the effect of tumour cells on monocyte subpopulations. Anticancer Res 2010; 30: 3515-3519."},{"key":"ref86","doi-asserted-by":"publisher","first-page":"124","DOI":"10.1016\/j.tins.2024.11.008","article-title":"Peripheral, central, and chemotherapy-induced neuropathic changes in pancreatic cancer","volume":"48","author":"Jiang","year":"2025","unstructured":"Jiang L, Cai S, Weng Z, Zhang S and Jiang SH. Peripheral, central, and chemotherapy-induced neuropathic changes in pancreatic cancer. Trends Neurosci 2025; 48: 124-139.","journal-title":"Trends Neurosci"},{"key":"ref87","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1186\/s40425-019-0734-6","article-title":"Immunosuppression by monocytic myeloid-derived suppressor cells in patients with pancreatic ductal carcinoma is orchestrated by STAT3","volume":"7","author":"Trovato","year":"2019","unstructured":"Trovato R, Fiore A, Sartori S, Can&#xE8; S, Giugno R, Cascione L, Paiella S, Salvia R, De Sanctis F, Poffe O, Anselmi C, Hofer F, Sartoris S, Piro G, Carbone C, Corbo V, Lawlor R, Solito S, Pinton L, Mandruzzato S, Bassi C, Scarpa A, Bronte V and Ugel S. Immunosuppression by monocytic myeloid-derived suppressor cells in patients with pancreatic ductal carcinoma is orchestrated by STAT3. J Immunother Cancer 2019; 7: 255.","journal-title":"J Immunother Cancer"},{"key":"ref88","doi-asserted-by":"publisher","unstructured":"Javeed N, Gustafson MP, Dutta SK, Lin Y, Bamlet WR, Oberg AL, Petersen GM, Chari ST, Dietz AB and Mukhopadhyay D. Immunosuppressive CD14(+)HLA-DR(lo\/neg) monocytes are elevated in pancreatic cancer and &#x201C;primed&#x201D; by tumor-derived exosomes. Oncoimmunology 2017; 6: e1252013.","DOI":"10.1080\/2162402X.2016.1252013"},{"key":"ref89","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1038\/s41586-023-06685-2","article-title":"IL-1&#x3B2;(+) macrophages fuel pathogenic inflammation in pancreatic cancer","volume":"623","author":"Caronni","year":"2023","unstructured":"Caronni N, La Terza F, Vittoria FM, Barbiera G, Mezzanzanica L, Cuzzola V, Barresi S, Pellegatta M, Canevazzi P, Dunsmore G, Leonardi C, Montaldo E, Lusito E, Dugnani E, Citro A, Ng MSF, Schiavo Lena M, Drago D, Andolfo A, Brugiapaglia S, Scagliotti A, Mortellaro A, Corbo V, Liu Z, Mondino A, Dellabona P, Piemonti L, Taveggia C, Doglioni C, Cappello P, Novelli F, Iannacone M, Ng LG, Ginhoux F, Crippa S, Falconi M, Bonini C, Naldini L, Genua M and Ostuni R. IL-1&#x3B2;(+) macrophages fuel pathogenic inflammation in pancreatic cancer. Nature 2023; 623: 415-422.","journal-title":"Nature"},{"key":"ref90","doi-asserted-by":"publisher","unstructured":"Witkowski MT, Dolgalev I, Evensen NA, Ma C, Chambers T, Roberts KG, Sreeram S, Dai Y, Tikhonova AN, Lasry A, Qu C, Pei D, Cheng C, Robbins GA, Pierro J, Selvaraj S, Mezzano V, Daves M, Lupo PJ, Scheurer ME, Loomis CA, Mullighan CG, Chen W, Rabin KR, Tsirigos A, Carroll WL and Aifantis I. Extensive remodeling of the immune microenvironment in B Cell Acute lymphoblastic leukemia. Cancer Cell 2020; 37: 867-882, e12.","DOI":"10.1016\/j.ccell.2020.04.015"},{"key":"ref91","doi-asserted-by":"publisher","first-page":"755623","DOI":"10.3389\/fimmu.2021.755623","article-title":"Nonclassical monocytes are prone to migrate into tumor in diffuse large B-Cell lymphoma","volume":"12","author":"Le Gallou","year":"2021","unstructured":"Le Gallou S, Lhomme F, Irish JM, Mingam A, Pangault C, Monvoisin C, Ferrant J, Azzaoui I, Rossille D, Bouabdallah K, Damaj G, Cartron G, Godmer P, Le Gouill S, Casasnovas RO, Molina TJ, Houot R, Lamy T, Tarte K, Fest T and Roussel M. Nonclassical monocytes are prone to migrate into tumor in diffuse large B-Cell lymphoma. Front Immunol 2021; 12: 755623.","journal-title":"Front Immunol"},{"key":"ref92","doi-asserted-by":"publisher","first-page":"650","DOI":"10.1111\/ijlh.12203","article-title":"CD14(+) HLA-DR low\/(-) monocytes as indicator of disease aggressiveness in B-cell non-Hodgkin lymphoma","volume":"36","author":"Khalifa","year":"2014","unstructured":"Khalifa KA, Badawy HM, Radwan WM, Shehata MA and Bassuoni MA. CD14(+) HLA-DR low\/(-) monocytes as indicator of disease aggressiveness in B-cell non-Hodgkin lymphoma. Int J Lab Hematol 2014; 36: 650-655.","journal-title":"Int J Lab Hematol"},{"key":"ref93","doi-asserted-by":"publisher","first-page":"42","DOI":"10.1186\/s41927-025-00470-6","article-title":"IgA vasculitis associated with chronic myelomonocytic leukemia","volume":"9","author":"Rouvi&#xE8","year":"2025","unstructured":"Rouvi&#xE8;re B, Chasset F, Abisror N, Hirsch P, Fain O and M&#xE9;kinian A; MINHEMON (French network on immune diseases associated with hemopathies and cancers). IgA vasculitis associated with chronic myelomonocytic leukemia. BMC Rheumatol 2025; 9: 42.","journal-title":"BMC Rheumatol"},{"key":"ref94","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1038\/s41375-024-02511-4","article-title":"Multi-omic analysis of chronic myelomonocytic leukemia monocytes reveals metabolic and immune dysregulation leading to altered macrophage polarization","volume":"39","author":"Addinsell","year":"2025","unstructured":"Addinsell HM, Cant R, Hull NJ, Wang YH, Somervaille TCP, Wiseman DH and Batta K. Multi-omic analysis of chronic myelomonocytic leukemia monocytes reveals metabolic and immune dysregulation leading to altered macrophage polarization. Leukemia 2025; 39: 770-774.","journal-title":"Leukemia"},{"key":"ref95","doi-asserted-by":"publisher","first-page":"1703","DOI":"10.1038\/s41375-022-01613-1","article-title":"The 5th edition of the World Health Organization Classification of haematolymphoid tumours: myeloid and histiocytic\/dendritic neoplasms","volume":"36","author":"Khoury","year":"2022","unstructured":"Khoury JD, Solary E, Abla O, Akkari Y, Alaggio R, Apperley JF, Bejar R, Berti E, Busque L, Chan JKC, Chen W, Chen X, Chng WJ, Choi JK, Colmenero I, Coupland SE, Cross NCP, De Jong D, Elghetany MT, Takahashi E, Emile JF, Ferry J, Fogelstrand L, Fontenay M, Germing U, Gujral S, Haferlach T, Harrison C, Hodge JC, Hu S, Jansen JH, Kanagal-Shamanna R, Kantarjian HM, Kratz CP, Li XQ, Lim MS, Loeb K, Loghavi S, Marcogliese A, Meshinchi S, Michaels P, Naresh KN, Natkunam Y, Nejati R, Ott G, Padron E, Patel KP, Patkar N, Picarsic J, Platzbecker U, Roberts I, Schuh A, Sewell W, Siebert R, Tembhare P, Tyner J, Verstovsek S, Wang W, Wood B, Xiao W, Yeung C and Hochhaus A. The 5th edition of the World Health Organization Classification of haematolymphoid tumours: myeloid and histiocytic\/dendritic neoplasms. Leukemia 2022; 36: 1703-1719.","journal-title":"Leukemia"},{"key":"ref96","doi-asserted-by":"publisher","first-page":"3804","DOI":"10.1038\/s41467-025-59040-6","article-title":"Cellular immunotherapy targeting CLL-1 for juvenile myelomonocytic leukemia","volume":"16","author":"Werner","year":"2025","unstructured":"Werner J, Lee AG, Zhang C, Abelson S, Xirenayi S, Rivera J, Yousuf K, Shin H, Pati&#xF1;o-Escobar B, Bachl S, Mandal K, Barpanda A, Ramos E, Izgutdina A, Chaudhuri S, Temple WC, Bhatnagar S, Dardis JK, Meyer J, Morales C, Meshinchi S, Loh ML, Braun B, Tasian SK, Wiita AP and Stieglitz E. Cellular immunotherapy targeting CLL-1 for juvenile myelomonocytic leukemia. Nat Commun 2025; 16: 3804.","journal-title":"Nat Commun"},{"key":"ref97","doi-asserted-by":"publisher","first-page":"511","DOI":"10.1186\/s12967-025-06516-0","article-title":"T-lymphocytes suppression by CD14(+) monocytes with high expression of ULK2 in patients with multiple myeloma","volume":"23","author":"Peng","year":"2025","unstructured":"Peng F, Liu Z, Jiang F, Li N, Wang H, Meng N, Liu H, Ding K and Fu R. T-lymphocytes suppression by CD14(+) monocytes with high expression of ULK2 in patients with multiple myeloma. J Transl Med 2025; 23: 511.","journal-title":"J Transl Med"}],"container-title":["American Journal of Cancer Research"],"original-title":[],"link":[{"URL":"https:\/\/e-century.us\/files\/ajcr\/15\/8\/ajcr0164526.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T01:58:30Z","timestamp":1766023110000},"score":1,"resource":{"primary":{"URL":"https:\/\/e-century.us\/files\/ajcr\/15\/8\/ajcr0164526.pdf"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":98,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2025]]}},"URL":"https:\/\/doi.org\/10.62347\/cutm4281","relation":{},"ISSN":["2156-6976"],"issn-type":[{"value":"2156-6976","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025]]}}}